PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_016502014.1
Organism
Nicotiana tabacum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family MYB
Protein Properties Length: 316aa    MW: 36390.3 Da    PI: 5.2938
Description MYB family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_016502014.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Myb_DNA-binding41.92.3e-132873146
                     TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHH CS
  Myb_DNA-binding  1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqk 46
                     +g+W +eEd+ l++ vk++G+++W++I ++  + Rt+k+c++rw +
   XP_016502014.1 28 KGPWKAEEDQVLLNHVKKYGPRDWSSIRSKGLLQRTGKSCRLRWVN 73
                     79*************************8887799**********87 PP
2Myb_DNA-binding44.34.1e-1484123344
                      SS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHH CS
  Myb_DNA-binding   3 rWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrw 44 
                      ++++eE+   +++ +q+G++ W++Ia +++ gRt++++k++w
   XP_016502014.1  84 KFSAEEERTVIELQAQFGNK-WARIATYLP-GRTDNDVKNFW 123
                      79******************.*********.*********** PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.603.5E-212376IPR009057Homeodomain-like
PROSITE profilePS5129420.8142379IPR017930Myb domain
SuperFamilySSF466892.73E-2826123IPR009057Homeodomain-like
SMARTSM007174.2E-112777IPR001005SANT/Myb domain
CDDcd001676.86E-113075No hitNo description
PfamPF139214.0E-123181No hitNo description
Gene3DG3DSA:1.10.10.602.1E-1877129IPR009057Homeodomain-like
PROSITE profilePS5129417.91780131IPR017930Myb domain
SMARTSM007178.7E-1381129IPR001005SANT/Myb domain
CDDcd001672.46E-1084123No hitNo description
PfamPF002491.3E-1284123IPR001005SANT/Myb domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0003677Molecular FunctionDNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 316 aa     Download sequence    Send to blast
MEGRRSSTSS SYNRSRYQFE HNEDEIKKGP WKAEEDQVLL NHVKKYGPRD WSSIRSKGLL  60
QRTGKSCRLR WVNKLRPNLK NGVKFSAEEE RTVIELQAQF GNKWARIATY LPGRTDNDVK  120
NFWSSRQKRL ARILRTSAPQ PAKPQNNDNN KNNDSQNDVF QDSPPIEAPK FSSSTDQEES  180
LSKSQSCSSS YFDNSHNMVP FPELVNPNSI AFESNLLQLD FTPNDYKLGI ESSHIQTDFG  240
VPLENQEFNM PNFIDVFGQF NGSELDNVQV PFVERSCCDN IVKREIDKPL TPDSFIDDFP  300
LDMFDHIEPL PSPSEW
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1h8a_C9e-29131297126MYB TRANSFORMING PROTEIN
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that acts as a positive regulator of male germline development by promoting both gametic cell specification and cell cycle progression (PubMed:15694308, PubMed:15618418, PubMed:19300502, PubMed:21285328). Binds to canonical MYB sites 5'-AACCGTC-3', 5'-AAACCGC-3' and 5'-AACCGT-3' in promoters to trigger the expression of male germline-specific or enriched genes (e.g. MGH3, GEX2 and GCS1), including those required for fertilization (PubMed:21285328, PubMed:19300502). Required for sperm cell specification leading to pollen maturation by activating a germline-specific regulon (PubMed:21285328, PubMed:15694308, PubMed:15618418, PubMed:19300502). Involved in pollen mitosis entry at G2-M transition via the regulation of CYCB1-1, DAZ1 and DAZ2 expression (PubMed:15618418, PubMed:19300502, PubMed:24876252). {ECO:0000269|PubMed:15618418, ECO:0000269|PubMed:15694308, ECO:0000269|PubMed:19300502, ECO:0000269|PubMed:21285328, ECO:0000269|PubMed:24876252}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Repressed by the microRNA 159 (miR159); the production of miR159 is stimulated by the anaphase promoting complex/cyclosome (APC/C) (PubMed:21441434). Activated by ARID1 in male germline cells via specific histone acetylation regulation (e.g. H3K9Ac) (PubMed:25057814). {ECO:0000269|PubMed:21441434, ECO:0000269|PubMed:25057814}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAB0325370.0AB032537.2 Nicotiana tabacum B25 mRNA for hypothetical protein, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_016502014.10.0PREDICTED: transcription factor MYB57-like
SwissprotA0A178VEK73e-79DUO1_ARATH; Transcription factor DUO1
TrEMBLA0A1S4CM580.0A0A1S4CM58_TOBAC; transcription factor MYB57-like
STRINGXP_009768446.10.0(Nicotiana sylvestris)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA42072342
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G60460.16e-73MYB family protein
Publications ? help Back to Top
  1. Zheng B,He H,Zheng Y,Wu W,McCormick S
    An ARID domain-containing protein within nuclear bodies is required for sperm cell formation in Arabidopsis thaliana.
    PLoS Genet., 2014. 10(7): p. e1004421
    [PMID:25057814]
  2. Peters B, et al.
    A Conserved cis-Regulatory Module Determines Germline Fate through Activation of the Transcription Factor DUO1 Promoter.
    Plant Physiol., 2017. 173(1): p. 280-293
    [PMID:27624837]
  3. Zheng Z, et al.
    Target RNA Secondary Structure Is a Major Determinant of miR159 Efficacy.
    Plant Physiol., 2017. 174(3): p. 1764-1778
    [PMID:28515145]