PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

XP_016497357.1

Organism

Nicotiana tabacum

Taxonomic ID

4097

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana

Family

E2F/DP

Protein Properties

Length: 348aa MW: 38616 Da PI: 4.255

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
XP_016497357.1	genome	NCBI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	87	1.4e-27	26	91	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++l++++e+g+++ln++a++L +v ++RRiYDi+NVLe+++liekk kn+i+wkg XP_016497357.1 26 RYDSSLGLLTKKFINLIKHAEDGMLDLNQAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 91 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	7.0E-30	24	93	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	1.6E-34	26	91	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	1.16E-17	26	89	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	8.6E-25	28	91	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF144074	1.54E-33	105	208	No hit	No description
Pfam	PF16421	2.6E-33	107	206	IPR032198	E2F transcription factor, CC-MB domain
CDD	cd14660	1.20E-46	107	208	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 348 aa Download sequence Send to blast
KSNKSGPPTP VSNVGSPSPL TPANCRYDSS LGLLTKKFIN LIKHAEDGML DLNQAADTLE 60 VQKRRIYDIT NVLEGIGLIE KKLKNRIQWK GVDASRPGEV DNDAAILKAE TESLSMEERR 120 LDDQVRELQE KLRDMSEDED NQKWLFVTEE DLKSLPCFQN ETLIAVKAPH GTTLEVPDPD 180 EAVDYSQRRY RIILRSTMGP IDVYLVSQFE EKFEEMNSVE PSMAIPVASS SGSKDNPAME 240 RSTLSNSVTE NEVQTQNVDQ LSSDLGTSQD YGGGMVKVVP SDVDNDADYW LLSDAHVSIT 300 NMWEADPAVE WDGENLLHEF GIADLGTPRA HTPSAVTDVP TPMNVPPR

Sequence ? help Back to Top

Protein Sequence Length: 348 aa Download sequence Send to blast

KSNKSGPPTP VSNVGSPSPL TPANCRYDSS LGLLTKKFIN LIKHAEDGML DLNQAADTLE  60
VQKRRIYDIT NVLEGIGLIE KKLKNRIQWK GVDASRPGEV DNDAAILKAE TESLSMEERR  120
LDDQVRELQE KLRDMSEDED NQKWLFVTEE DLKSLPCFQN ETLIAVKAPH GTTLEVPDPD  180
EAVDYSQRRY RIILRSTMGP IDVYLVSQFE EKFEEMNSVE PSMAIPVASS SGSKDNPAME  240
RSTLSNSVTE NEVQTQNVDQ LSSDLGTSQD YGGGMVKVVP SDVDNDADYW LLSDAHVSIT  300
NMWEADPAVE WDGENLLHEF GIADLGTPRA HTPSAVTDVP TPMNVPPR

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	1e-26	19	92	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AC239738	7e-75	AC239738.5 Solanum lycopersicum strain Heinz 1706 chromosome 1 clone hba-240p19 map 1, complete sequence.
GenBank	HG975440	7e-75	HG975440.1 Solanum pennellii chromosome ch01, complete genome.
GenBank	HG975513	7e-75	HG975513.1 Solanum lycopersicum chromosome ch01, complete genome.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_016497357.1	0.0	PREDICTED: transcription factor E2FA-like, partial
Swissprot	Q9FNY0	1e-138	E2FA_ARATH; Transcription factor E2FA
TrEMBL	A0A1S4C7X9	0.0	A0A1S4C7X9_TOBAC; transcription factor E2FA-like
STRING	XP_009602094.1	0.0	(Nicotiana tomentosiformis)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA1077	24	84

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-142	E2F transcription factor 3

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]