PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_016489250.1
Organism
Nicotiana tabacum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family HSF
Protein Properties Length: 508aa    MW: 56102.4 Da    PI: 4.7062
Description HSF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_016489250.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HSF_DNA-bind113.61.3e-35351262102
                     HHHHHHHHHCTGGGTTTSEESSSSSEEEES-HHHHHHHTHHHHSTT--HHHHHHHHHHTTEEE---SSBTTTTXTTSEEEEESXXXXXXXXXXXX CS
    HSF_DNA-bind   2 FlkklyeiledeelkeliswsengnsfvvldeeefakkvLpkyFkhsnfaSFvRQLnmYgFkkvkdeekkskskekiweFkhksFkkgkkellek 96 
                     Fl k+y++++d+++++++sw   +nsfvv+d+ efa+++LpkyFkh+nf+SFvRQLn+YgF+kv+ ++         weF+++ F +g+k+ll++
  XP_016489250.1  35 FLVKTYDMVDDPSTDKIVSWGPANNSFVVWDPPEFARDLLPKYFKHNNFSSFVRQLNTYGFRKVDPDR---------WEFANEGFLRGQKHLLRS 120
                     9********************999*****************************************999.........****************** PP

                     XXXXXX CS
    HSF_DNA-bind  97 ikrkks 102
                     i r+k 
  XP_016489250.1 121 ISRRKP 126
                     ***986 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.106.1E-4027118IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467854.08E-3630124IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM004157.0E-6431124IPR000232Heat shock factor (HSF)-type, DNA-binding
PfamPF004477.3E-3235124IPR000232Heat shock factor (HSF)-type, DNA-binding
PRINTSPR000564.6E-203558IPR000232Heat shock factor (HSF)-type, DNA-binding
PRINTSPR000564.6E-207385IPR000232Heat shock factor (HSF)-type, DNA-binding
PROSITE patternPS0043407498IPR000232Heat shock factor (HSF)-type, DNA-binding
PRINTSPR000564.6E-208698IPR000232Heat shock factor (HSF)-type, DNA-binding
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009408Biological Processresponse to heat
GO:0005634Cellular Componentnucleus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 508 aa     Download sequence    Send to blast
MTSNSSAAAD GGGGGAPPSQ PAPAPMPSAN APPPFLVKTY DMVDDPSTDK IVSWGPANNS  60
FVVWDPPEFA RDLLPKYFKH NNFSSFVRQL NTYGFRKVDP DRWEFANEGF LRGQKHLLRS  120
ISRRKPAHGH AQQQQQPHGQ SASVGACVEV GKFGLEEEVE RLKRDKNVLM QELVKLRQQQ  180
QTTDNQLQGM VQRLQGMEQR QQQMMSFLAK AVNSPGFLAQ FVQQQNESNR RIAEGSKKRR  240
IKQDIESQDH SVTPADGQIV KYQPVMNESA KAMLRELSKL DSSPRLENFS NSPESFLIGD  300
GSPQSNASST RVSGVTLQEV PPTSGQPLLS TASAIAGQSS SSEITNNQLS EISSLVGAHD  360
LPPVSLSASD MIMPELSQLQ EILPGNNMDI IRSEMENDSF MDSSVGVDEK MPLDIGSFSP  420
DPQIEWQTGL LDDIGELPSV GDPFWEKFLQ SPSPGETEEM DLAAMDDISN ETKPQENGWD  480
KTQHMDHLTE QMGXTNIKQS KSMIWLSK
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5d5u_B9e-282712418129Heat shock factor protein 1
5d5v_B9e-282712418129Heat shock factor protein 1
5d5v_D9e-282712418129Heat shock factor protein 1
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1236241KKRRIK
Functional Description ? help Back to Top
Source Description
UniProtDNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. {ECO:0000250}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankX676000.0X67600.1 L.peruvianum Lp-hsf8 mRNA for heat stress transcription factor 8.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009619930.20.0PREDICTED: LOW QUALITY PROTEIN: heat shock factor protein HSF8-like
RefseqXP_016489250.10.0PREDICTED: LOW QUALITY PROTEIN: heat shock factor protein HSF8-like
SwissprotQ401520.0HSF8_SOLLC; Heat shock factor protein HSF8
TrEMBLA0A1S4BK550.0A0A1S4BK55_TOBAC; LOW QUALITY PROTEIN: heat shock factor protein HSF8-like
STRINGXP_009619930.10.0(Nicotiana tomentosiformis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA64131931
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G32330.11e-121heat shock transcription factor A1D
Publications ? help Back to Top
  1. Zhu B, et al.
    Identification and characterization of a novel heat shock transcription factor gene, GmHsfA1, in soybeans (Glycine max).
    J. Plant Res., 2006. 119(3): p. 247-56
    [PMID:16570125]
  2. Cai SY, et al.
    HsfA1a upregulates melatonin biosynthesis to confer cadmium tolerance in tomato plants.
    J. Pineal Res., 2017.
    [PMID:28095626]
  3. Zhou J, et al.
    Heat Shock Factor HsfA1a Is Essential for R Gene-Mediated Nematode Resistance and Triggers H2O2 Production1.
    Plant Physiol., 2018. 176(3): p. 2456-2471
    [PMID:29339397]