PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_016461958.1
Organism
Nicotiana tabacum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family WRKY
Protein Properties Length: 513aa    MW: 56400.1 Da    PI: 7.604
Description WRKY family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_016461958.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1WRKY96.61.7e-30227282359
                     -SS-EEEEEEE--TT-SS-EEEEEE-STT---EEEEEE-SSSTTEEEEEEES--SS- CS
            WRKY   3 DgynWrKYGqKevkgsefprsYYrCtsagCpvkkkversaedpkvveitYegeHnhe 59 
                     DgynWrKYGqK+vk se+prsYY+Ct+ +Cpvkkkve s  d++++eitY+g+Hnhe
  XP_016461958.1 227 DGYNWRKYGQKMVKASECPRSYYKCTHLKCPVKKKVELSI-DGHITEITYKGHHNHE 282
                     9***************************************.***************7 PP
2WRKY104.94.2e-33399457159
                     ---SS-EEEEEEE--TT-SS-EEEEEE-STT---EEEEEE-SSSTTEEEEEEES--SS- CS
            WRKY   1 ldDgynWrKYGqKevkgsefprsYYrCtsagCpvkkkversaedpkvveitYegeHnhe 59 
                     ldDg++WrKYGqK+vkg+++prsYYrCt++gC+v+k+ver++ dpk+v++tYeg+Hnh+
  XP_016461958.1 399 LDDGFKWRKYGQKVVKGNHHPRSYYRCTYPGCNVRKHVERASADPKAVITTYEGKHNHD 457
                     59********************************************************7 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5081121.781220284IPR003657WRKY domain
Gene3DG3DSA:2.20.25.809.1E-27220284IPR003657WRKY domain
SuperFamilySSF1182903.4E-24224284IPR003657WRKY domain
SMARTSM007742.5E-32225283IPR003657WRKY domain
PfamPF031061.7E-22227282IPR003657WRKY domain
Gene3DG3DSA:2.20.25.803.0E-36385459IPR003657WRKY domain
SuperFamilySSF1182901.83E-29391459IPR003657WRKY domain
PROSITE profilePS5081135.898394459IPR003657WRKY domain
SMARTSM007741.2E-39399458IPR003657WRKY domain
PfamPF031068.3E-26400457IPR003657WRKY domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 513 aa     Download sequence    Send to blast
MGEKFKASAV SELTIPPRAP SFEAFFGGGN MPYFSPGPMT LVSSFFSESE YPSFSQLLAG  60
AMASPLAKPP TLFPENSSGE ENCKEGNQKN LGYKQNRPMS LMVAQNSPLF MIPTGLSPSG  120
LLNSPGFLSP LQSPFGMSHQ QALAHVTAQA ALSHSYLQTQ AEYHFSSQGT SAQVLGNETS  180
TEPTESSLRP QLNAMPSDQQ NKKIELPLVS QSEDKPSFAS ADRPACDGYN WRKYGQKMVK  240
ASECPRSYYK CTHLKCPVKK KVELSIDGHI TEITYKGHHN HELPQPSKRR RDSCAQDGSD  300
CSKAKPESEM QSGTEVNGLN GALPARSGQV STEMASGLLL SNECDKIEDT ATAAEEGHDN  360
EPNMKRMKTA VEAPNLASSH KAVSESKIVV QTRSEVDILD DGFKWRKYGQ KVVKGNHHPR  420
SYYRCTYPGC NVRKHVERAS ADPKAVITTY EGKHNHDIPI ARNRGHSTAQ DSTRQLNEQD  480
VATWRPSLHE NVAFHNTNDI PVCRQLKEEQ IAA
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1wj2_A5e-37227459877Probable WRKY transcription factor 4
2lex_A5e-37227459877Probable WRKY transcription factor 4
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor that binds specifically to the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Has a positive role in resistance to necrotrophic pathogens (e.g. Botrytis cinerea), but a negative effect on plant resistance to biotrophic pathogens (e.g. Pseudomonas syringae). {ECO:0000269|PubMed:18570649, ECO:0000269|PubMed:22219184}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By biotic and abiotic stresses such as pathogen infection (e.g. Botrytis cinerea and Pseudomonas syringae), salicylic acid (SA), jasmonic acid (JA), ethylene (ACC), liquid infiltration or spraying, and strongly during leaf senescence. {ECO:0000269|PubMed:11449049, ECO:0000269|PubMed:11722756, ECO:0000269|PubMed:18570649}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAB7111350.0AB711135.1 Nicotiana benthamiana NbWRKY14 mRNA for transcription factor, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_016461958.10.0PREDICTED: probable WRKY transcription factor 3
SwissprotQ9XI901e-126WRKY4_ARATH; Probable WRKY transcription factor 4
TrEMBLA0A1S3ZC350.0A0A1S3ZC35_TOBAC; probable WRKY transcription factor 3
STRINGXP_009768106.10.0(Nicotiana sylvestris)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA43142344
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G13960.11e-121WRKY DNA-binding protein 4
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  3. Aamir M, et al.
    Structural and Functional Insights into WRKY3 and WRKY4 Transcription Factors to Unravel the WRKY-DNA (W-Box) Complex Interaction in Tomato (Solanum lycopersicum L.). A Computational Approach.
    Front Plant Sci, 2017. 8: p. 819
    [PMID:28611792]