PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_016453937.1
Organism
Nicotiana tabacum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family WRKY
Protein Properties Length: 525aa    MW: 57460.2 Da    PI: 8.3361
Description WRKY family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_016453937.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1WRKY107.28.2e-34232288259
                     --SS-EEEEEEE--TT-SS-EEEEEE-STT---EEEEEE-SSSTTEEEEEEES--SS- CS
            WRKY   2 dDgynWrKYGqKevkgsefprsYYrCtsagCpvkkkversaedpkvveitYegeHnhe 59 
                     dDgynWrKYGqK+vkgse+prsYY+Ct+++Cpvkkkvers  d++v+ei+Y+g+Hnh+
  XP_016453937.1 232 DDGYNWRKYGQKQVKGSEYPRSYYKCTHSNCPVKKKVERSL-DGQVTEIIYKGQHNHQ 288
                     8****************************************.***************8 PP
2WRKY106.21.6e-33411469159
                     ---SS-EEEEEEE--TT-SS-EEEEEE-STT---EEEEEE-SSSTTEEEEEEES--SS- CS
            WRKY   1 ldDgynWrKYGqKevkgsefprsYYrCtsagCpvkkkversaedpkvveitYegeHnhe 59 
                     ldDgy+WrKYGqK vkg+++prsYY+Cts+gC+v+k+ver+a+dpk+v++tYeg+Hnh+
  XP_016453937.1 411 LDDGYRWRKYGQKIVKGNPYPRSYYKCTSQGCNVRKHVERAATDPKAVITTYEGKHNHD 469
                     59********************************************************7 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5081124.134226290IPR003657WRKY domain
Gene3DG3DSA:2.20.25.805.2E-30226290IPR003657WRKY domain
SuperFamilySSF1182902.09E-26229290IPR003657WRKY domain
SMARTSM007741.8E-37231289IPR003657WRKY domain
PfamPF031065.8E-26232288IPR003657WRKY domain
Gene3DG3DSA:2.20.25.803.1E-37396471IPR003657WRKY domain
SuperFamilySSF1182909.81E-30403471IPR003657WRKY domain
PROSITE profilePS5081139.066406471IPR003657WRKY domain
SMARTSM007741.7E-39411470IPR003657WRKY domain
PfamPF031062.3E-26412469IPR003657WRKY domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 525 aa     Download sequence    Send to blast
MAENEGSSSS SSTSRAQLLR PTITLPPRNS MESLFSVGSS GISPGPMTLV SSFFSDNDPD  60
SDCRSFSQLL AGAMSSPAGF SSVRPGFRPV PPPYTAATAQ EYKQNRPTGL VISQSPTTFT  120
VPPGLSPGGL LDGFFSPGQG PFGMSHQQVL AQFTTQAAQA QSQMHIRPDY PSSLTAAATS  180
LSQFQSLASN AAANQQIPPP ALNPNIVKES SDVSLSDQRS EPASFAVDKP ADDGYNWRKY  240
GQKQVKGSEY PRSYYKCTHS NCPVKKKVER SLDGQVTEII YKGQHNHQPP QSSKRSKESG  300
NPNGNYNSQG SYEPSTEGLT GNFNKPKEGE TSYSLRMKDH ESSQATHDQI SGSSDSEEVG  360
DAETRVDGRD IDERESKRRA VEVQTSEAAC SHRTVTEPRI IVQTTSEVDL LDDGYRWRKY  420
GQKIVKGNPY PRSYYKCTSQ GCNVRKHVER AATDPKAVIT TYEGKHNHDV PAARNSSHNT  480
TNNSMSQLRP HNPVVDKPAA MRRTNFPNNE QQPIALLRFK EEQIT
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1wj2_A2e-42232472878Probable WRKY transcription factor 4
2lex_A2e-42232472878Probable WRKY transcription factor 4
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor that binds specifically to the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Has a positive role in resistance to necrotrophic pathogens (e.g. Botrytis cinerea), but a negative effect on plant resistance to biotrophic pathogens (e.g. Pseudomonas syringae). {ECO:0000269|PubMed:18570649, ECO:0000269|PubMed:22219184}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By biotic and abiotic stresses such as pathogen infection (e.g. Botrytis cinerea and Pseudomonas syringae), salicylic acid (SA), jasmonic acid (JA), ethylene (ACC), liquid infiltration or spraying, and strongly during leaf senescence. {ECO:0000269|PubMed:11449049, ECO:0000269|PubMed:11722756, ECO:0000269|PubMed:18570649}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAB7111330.0AB711133.1 Nicotiana benthamiana NbWRKY12 mRNA for transcription factor, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_016453937.10.0PREDICTED: probable WRKY transcription factor 4
SwissprotQ9XI901e-168WRKY4_ARATH; Probable WRKY transcription factor 4
TrEMBLA0A1S3YPI60.0A0A1S3YPI6_TOBAC; probable WRKY transcription factor 4
STRINGXP_009794188.10.0(Nicotiana sylvestris)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA41072445
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G13960.11e-140WRKY DNA-binding protein 4
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  3. Aamir M, et al.
    Structural and Functional Insights into WRKY3 and WRKY4 Transcription Factors to Unravel the WRKY-DNA (W-Box) Complex Interaction in Tomato (Solanum lycopersicum L.). A Computational Approach.
    Front Plant Sci, 2017. 8: p. 819
    [PMID:28611792]