PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_016445173.1
Organism
Nicotiana tabacum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family HD-ZIP
Protein Properties Length: 717aa    MW: 79037.8 Da    PI: 6.7205
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_016445173.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox60.52.6e-192782156
                    TT--SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS
        Homeobox  1 rrkRttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakek 56
                    +++ +++t++q+++Le+ F+++++p++++r +L++ lgL  rq+k+WFqNrR+++k
  XP_016445173.1 27 KKRYHRHTANQIQRLESIFKECPHPDEKTRLQLSRDLGLAPRQIKFWFQNRRTQMK 82
                    678899***********************************************998 PP
2START176.12.2e-552254502206
                     HHHHHHHHHHHHHHHC-TT-EEEE....EXCCTTEEEEEEESSS.......SCEEEEEEEECCSCHHHHHHHHHCCCGGCT-TT-S....EEEEE CS
           START   2 laeeaaqelvkkalaeepgWvkss....esengdevlqkfeeskv......dsgealrasgvvdmvlallveellddkeqWdetla....kaetl 82 
                     +a  a++el+++++ +ep+W+ks+    + +n + + ++f+++++       ++ea+r+sgvv+m+   lv  ++d + +W+e ++    ka tl
  XP_016445173.1 225 IAGNAMEELIRLVQTNEPLWMKSAidgkDVLNFENYDRIFPRANShlknhnVRIEASRDSGVVIMNGLALVDMFMDAN-KWQEFFPtivsKARTL 318
                     67899*********************999999********9999999*9999**************************.**************** PP

                     EEECTT......EEEEEEEEXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--.-TTSEE-EESSEEEEEEEECTCEEEEEEEE-E CS
           START  83 evissg......galqlmvaelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppesssvvRaellpSgiliepksnghskvtwvehv 170
                     evissg      ++lqlm+ elq+lsplvp R  +f+R+++q ++ +w+ivdvS d +q++  s  + ++++lpSg+li++++ng+skvtw+ehv
  XP_016445173.1 319 EVISSGvmgsrmSTLQLMYEELQVLSPLVPtRQLYFLRFCQQIEQSSWAIVDVSYDITQENLYSNTSCKVHRLPSGCLIQDMPNGYSKVTWMEHV 413
                     ************************************************************977******************************** PP

                     E--SSXX.HHHHHHHHHHHHHHHHHHHHHHTXXXXXX CS
           START 171 dlkgrlp.hwllrslvksglaegaktwvatlqrqcek 206
                     +++++ + h l r l++sgla+ga +wv tlqr ce+
  XP_016445173.1 414 EVEEKGImHRLCRDLIHSGLAFGAGRWVGTLQRVCER 450
                     *****999***************************97 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF466892.26E-191084IPR009057Homeodomain-like
Gene3DG3DSA:1.10.10.601.9E-211786IPR009057Homeodomain-like
PROSITE profilePS5007117.5082484IPR001356Homeobox domain
SMARTSM003892.3E-182588IPR001356Homeobox domain
CDDcd000867.28E-182685No hitNo description
PfamPF000465.2E-172782IPR001356Homeobox domain
PROSITE patternPS0002705982IPR017970Homeobox, conserved site
PROSITE profilePS5084847.661215453IPR002913START domain
SuperFamilySSF559611.65E-32216452No hitNo description
CDDcd088754.43E-114219449No hitNo description
SMARTSM002341.3E-45224450IPR002913START domain
PfamPF018522.2E-47225450IPR002913START domain
SuperFamilySSF559618.49E-22471707No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0008289Molecular Functionlipid binding
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 717 aa     Download sequence    Send to blast
MEYGSGGGGG TSSGGGGDPH DAAERRKKRY HRHTANQIQR LESIFKECPH PDEKTRLQLS  60
RDLGLAPRQI KFWFQNRRTQ MKAQHERADN CALRAENDKI RCENIAIREA LKNVICPSCG  120
GPPVTEDSYF DEQKLRIENM QLKEELDKVS SIAAKYIGRP ISQLPPVQPI HLSSLDLSMS  180
SFVGHVPNSL DLDLDLLPGS SSTIPGLAFA SLNLSDIDKS LMADIAGNAM EELIRLVQTN  240
EPLWMKSAID GKDVLNFENY DRIFPRANSH LKNHNVRIEA SRDSGVVIMN GLALVDMFMD  300
ANKWQEFFPT IVSKARTLEV ISSGVMGSRM STLQLMYEEL QVLSPLVPTR QLYFLRFCQQ  360
IEQSSWAIVD VSYDITQENL YSNTSCKVHR LPSGCLIQDM PNGYSKVTWM EHVEVEEKGI  420
MHRLCRDLIH SGLAFGAGRW VGTLQRVCER YACLMVNSNP THGLGGVIPS PEGKRSMMKL  480
AKRMVSNFCA SINPSNGHQW NTNSGLNEFE VRATLQKSTD PGQPNGVIIS AATTIWLPVP  540
PQNVFNFFRD ERTRPQWDVL SNQNPVQEVA HIANGSHPGN CISVLRAYNT SQNNMLILQE  600
SCIDSSGALV VYSPVDVPAI NIAMSGEDPT YIPLLPSGFT ILPDGHQLDQ DAASCSSSSN  660
ASTIGGRSGG SLITVVFQIL VSSLPSAKMS PESVNTVNNL IGSTVHQIKA ALNCSTS
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor which acts as positive regulator of drought stress tolerance. Can transactivate CIPK3, NCED3 and ERECTA (PubMed:18451323). Transactivates several cell-wall-loosening protein genes by directly binding to HD motifs in their promoters. These target genes play important roles in coordinating cell-wall extensibility with root development and growth (PubMed:24821957). Transactivates CYP74A/AOS, AOC3, OPR3 and 4CLL5/OPCL1 genes by directly binding to HD motifs in their promoters. These target genes are involved in jasmonate (JA) biosynthesis, and JA signaling affects root architecture by activating auxin signaling, which promotes lateral root formation (PubMed:25752924). Acts as negative regulator of trichome branching (PubMed:16778018, PubMed:24824485). Required for the establishment of giant cell identity on the abaxial side of sepals (PubMed:23095885). May regulate cell differentiation and proliferation during root and shoot meristem development (PubMed:25564655). {ECO:0000269|PubMed:16778018, ECO:0000269|PubMed:18451323, ECO:0000269|PubMed:23095885, ECO:0000269|PubMed:24821957, ECO:0000269|PubMed:24824485, ECO:0000269|PubMed:25564655, ECO:0000269|PubMed:25752924}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankHG9754421e-158HG975442.1 Solanum pennellii chromosome ch03, complete genome.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009786509.10.0PREDICTED: homeobox-leucine zipper protein HDG11-like
RefseqXP_016445173.10.0PREDICTED: homeobox-leucine zipper protein HDG11-like
SwissprotQ9FX310.0HDG11_ARATH; Homeobox-leucine zipper protein HDG11
TrEMBLA0A1S3XZ130.0A0A1S3XZ13_TOBAC; homeobox-leucine zipper protein HDG11-like
TrEMBLA0A1U7XHU30.0A0A1U7XHU3_NICSY; homeobox-leucine zipper protein HDG11-like
STRINGXP_009786509.10.0(Nicotiana sylvestris)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA24902351
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G73360.10.0homeodomain GLABROUS 11
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Khosla A, et al.
    HD-Zip Proteins GL2 and HDG11 Have Redundant Functions in Arabidopsis Trichomes, and GL2 Activates a Positive Feedback Loop via MYB23.
    Plant Cell, 2014. 26(5): p. 2184-2200
    [PMID:24824485]
  3. Horstman A, et al.
    AIL and HDG proteins act antagonistically to control cell proliferation.
    Development, 2015. 142(3): p. 454-64
    [PMID:25564655]
  4. Cai XT,Xu P,Wang Y,Xiang CB
    Activated expression of AtEDT1/HDG11 promotes lateral root formation in Arabidopsis mutant edt1 by upregulating jasmonate biosynthesis.
    J Integr Plant Biol, 2015. 57(12): p. 1017-30
    [PMID:25752924]
  5. Yu LH, et al.
    Arabidopsis EDT1/HDG11 improves drought and salt tolerance in cotton and poplar and increases cotton yield in the field.
    Plant Biotechnol. J., 2016. 14(1): p. 72-84
    [PMID:25879154]
  6. Zhu Z, et al.
    Overexpression of AtEDT1/HDG11 in Chinese Kale (Brassica oleracea var. alboglabra) Enhances Drought and Osmotic Stress Tolerance.
    Front Plant Sci, 2016. 7: p. 1285
    [PMID:27625663]
  7. Liu Y, et al.
    Overexpression of AtEDT1 promotes root elongation and affects medicinal secondary metabolite biosynthesis in roots of transgenic Salvia miltiorrhiza.
    Protoplasma, 2017. 254(4): p. 1617-1625
    [PMID:27915455]
  8. Ueda M, et al.
    Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote.
    Genes Dev., 2017. 31(6): p. 617-627
    [PMID:28404632]
  9. Lung SC, et al.
    Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors.
    New Phytol., 2018. 218(1): p. 183-200
    [PMID:29288621]
  10. Zheng G, et al.
    Over-Expression of Arabidopsis EDT1 Gene Confers Drought Tolerance in Alfalfa (Medicago sativa L.).
    Front Plant Sci, 2017. 8: p. 2125
    [PMID:29326737]