PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

XP_016436479.1

Organism

Nicotiana tabacum

Taxonomic ID

4097

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana

Family

G2-like

Protein Properties

Length: 474aa MW: 52350.5 Da PI: 6.3099

Description

G2-like family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
XP_016436479.1	genome	NCBI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	G2-like	105.5	3e-33	249	303	1	55
G2-like 1 kprlrWtpeLHerFveaveqLGGsekAtPktilelmkvkgLtlehvkSHLQkYRl 55 k r+rWtpeLHe Fveav++LGGsekAtPk +l+lm+v+gLt++hvkSHLQkYR+ XP_016436479.1 249 KSRMRWTPELHEVFVEAVSKLGGSEKATPKGVLKLMNVEGLTIYHVKSHLQKYRT 303 68****************************************************8 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS51294	11.873	246	306	IPR017930	Myb domain
SuperFamily	SSF46689	5.91E-18	247	303	IPR009057	Homeodomain-like
Gene3D	G3DSA:1.10.10.60	1.4E-30	248	305	IPR009057	Homeodomain-like
TIGRFAMs	TIGR01557	2.7E-25	249	303	IPR006447	Myb domain, plants
Pfam	PF00249	6.7E-10	251	302	IPR001005	SANT/Myb domain
Pfam	PF14379	5.8E-24	334	379	IPR025756	MYB-CC type transcription factor, LHEQLE-containing domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 474 aa Download sequence Send to blast
MDMRRTLCIQ RSSEAQHSNM GVSGAMSTSL SILPSLEEKY LKLPDSLYVF TEKERTANLI 60 SSQAIPSASR SGTVGHLLSS SSGPQKDFHF SPTSSQENRQ HNYAFISSEA SAATCQSSLL 120 CMHSTSLDNY PIGNSSNSWG KDAYHDFTNF PTNVPVQNGR VENLPVVMAS DDHAKRSDWQ 180 EWADQLINDD DVLHSSWSNI LVDVNPPDSE PKLLGASEVL ACRPQPTPIA PCEQSFPVGS 240 PSSSTALTKS RMRWTPELHE VFVEAVSKLG GSEKATPKGV LKLMNVEGLT IYHVKSHLQK 300 YRTARYKPEP SEGTPEKKPT SVTEMPSLDL KATMGITEAL RMQMEVQKQL HEQLEIQRKL 360 QLRIEEQGKY LEMMFEKTKG MGKDLKISSS LKTDEHPSPS TKTKHLPPND KSEALEQDPL 420 SSNNASSSAG EFTHGKNKEG NSLERETCED HGSDVRDLCS PPSKRAKTEE TSAS

Sequence ? help Back to Top

Protein Sequence Length: 474 aa Download sequence Send to blast

MDMRRTLCIQ RSSEAQHSNM GVSGAMSTSL SILPSLEEKY LKLPDSLYVF TEKERTANLI  60
SSQAIPSASR SGTVGHLLSS SSGPQKDFHF SPTSSQENRQ HNYAFISSEA SAATCQSSLL  120
CMHSTSLDNY PIGNSSNSWG KDAYHDFTNF PTNVPVQNGR VENLPVVMAS DDHAKRSDWQ  180
EWADQLINDD DVLHSSWSNI LVDVNPPDSE PKLLGASEVL ACRPQPTPIA PCEQSFPVGS  240
PSSSTALTKS RMRWTPELHE VFVEAVSKLG GSEKATPKGV LKLMNVEGLT IYHVKSHLQK  300
YRTARYKPEP SEGTPEKKPT SVTEMPSLDL KATMGITEAL RMQMEVQKQL HEQLEIQRKL  360
QLRIEEQGKY LEMMFEKTKG MGKDLKISSS LKTDEHPSPS TKTKHLPPND KSEALEQDPL  420
SSNNASSSAG EFTHGKNKEG NSLERETCED HGSDVRDLCS PPSKRAKTEE TSAS

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
6j4k_A	2e-29	249	307	2	60	Protein PHOSPHATE STARVATION RESPONSE 1
6j4k_B	2e-29	249	307	2	60	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_A	2e-29	249	307	2	60	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_C	2e-29	249	307	2	60	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_D	2e-29	249	307	2	60	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_F	2e-29	249	307	2	60	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_H	2e-29	249	307	2	60	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_J	2e-29	249	307	2	60	Protein PHOSPHATE STARVATION RESPONSE 1
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Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor involved in phosphate starvation signaling (PubMed:11511543, PubMed:17927693, PubMed:26586833). Binds as a dimer to P1BS, an imperfect palindromic sequence 5'-GNATATNC-3', to promote the expression of inorganic phosphate (Pi) starvation-responsive genes (PubMed:11511543, PubMed:20838596, PubMed:26586833). SPX1 is a competitive inhibitor of this DNA-binding (PubMed:25271326). PHR1 binding to its targets is low Pi-dependent (PubMed:25271326). Regulates the expression of miR399 (PubMed:20838596). Regulates the expression of IPS1 (At3g09922), a non-coding RNA that mimics the target of miR399 to block the cleavage of PHO2 under Pi-deficient conditions (PubMed:17643101). Regulates lipid remodeling and triacylglycerol accumulation during phosphorus starvation (PubMed:25680792). Required for the shoot-specific hypoxic response (PubMed:24753539). Regulates FER1 expression upon phosphate starvation, linking iron and phosphate homeostasis (PubMed:23788639). Contributes to the homeostasis of both sulfate and phosphate in plants under phosphate deficiency (PubMed:21261953). Required for adaptation to high light and retaining functional photosynthesis during phosphate starvation (PubMed:21910737). Involved in the coregulation of Zn and Pi homeostasis (PubMed:24420568). {ECO:0000269\|PubMed:11511543, ECO:0000269\|PubMed:17643101, ECO:0000269\|PubMed:17927693, ECO:0000269\|PubMed:20838596, ECO:0000269\|PubMed:21261953, ECO:0000269\|PubMed:21910737, ECO:0000269\|PubMed:23788639, ECO:0000269\|PubMed:24420568, ECO:0000269\|PubMed:24753539, ECO:0000269\|PubMed:25271326, ECO:0000269\|PubMed:25680792, ECO:0000269\|PubMed:26586833}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Only moderately up-regulated by Pi starvation. {ECO:0000269\|PubMed:11511543}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AC238342	0.0	AC238342.1 Solanum tuberosum cultivar RH89-039-16 chromosome 5 clone RH170O21, complete sequence.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_009775047.1	0.0	PREDICTED: protein PHR1-LIKE 1-like
Refseq	XP_016436479.1	0.0	PREDICTED: protein PHR1-LIKE 1-like
Swissprot	Q94CL7	1e-89	PHR1_ARATH; Protein PHOSPHATE STARVATION RESPONSE 1
TrEMBL	A0A1S3X9J6	0.0	A0A1S3X9J6_TOBAC; protein PHR1-LIKE 1-like
TrEMBL	A0A1U7W4U0	0.0	A0A1U7W4U0_NICSY; protein PHR1-LIKE 1-like
STRING	XP_009775047.1	0.0	(Nicotiana sylvestris)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA4582	21	39

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT4G28610.1	5e-92	phosphate starvation response 1

Publications ? help Back to Top
Duarte JM, et al. Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis. Mol. Biol. Evol., 2006. 23(2): p. 469-78 [PMID:16280546] Matsui K,Togami J,Mason JG,Chandler SF,Tanaka Y Enhancement of phosphate absorption by garden plants by genetic engineering: a new tool for phytoremediation. Biomed Res Int, 2013. 2013: p. 182032 [PMID:23984322] Jost R, et al. Differentiating phosphate-dependent and phosphate-independent systemic phosphate-starvation response networks in Arabidopsis thaliana through the application of phosphite. J. Exp. Bot., 2015. 66(9): p. 2501-14 [PMID:25697796] Zhou Z, et al. SPX proteins regulate Pi homeostasis and signaling in different subcellular level. Plant Signal Behav, 2015. 10(9): p. e1061163 [PMID:26224365] Bonnot C, et al. A chemical genetic strategy identify the PHOSTIN, a synthetic molecule that triggers phosphate starvation responses in Arabidopsis thaliana. New Phytol., 2016. 209(1): p. 161-76 [PMID:26243630] Khan GA,Vogiatzaki E,Glauser G,Poirier Y Phosphate Deficiency Induces the Jasmonate Pathway and Enhances Resistance to Insect Herbivory. Plant Physiol., 2016. 171(1): p. 632-44 [PMID:27016448] Velasco VM, et al. Acclimation of the crucifer Eutrema salsugineum to phosphate limitation is associated with constitutively high expression of phosphate-starvation genes. Plant Cell Environ., 2016. 39(8): p. 1818-34 [PMID:27038434] Yong-Villalobos L, et al. Phosphate starvation induces DNA methylation in the vicinity of cis-acting elements known to regulate the expression of phosphate-responsive genes. Plant Signal Behav, 2016. 11(5): p. e1173300 [PMID:27185363] Li Y,Wu H,Fan H,Zhao T,Ling HQ Characterization of the AtSPX3 Promoter Elucidates its Complex Regulation in Response to Phosphorus Deficiency. Plant Cell Physiol., 2016. 57(8): p. 1767-78 [PMID:27382128] Zhang H,Huang L,Hong Y,Song F BOTRYTIS-INDUCED KINASE1, a plasma membrane-localized receptor-like protein kinase, is a negative regulator of phosphate homeostasis in Arabidopsis thaliana. BMC Plant Biol., 2016. 16(1): p. 152 [PMID:27389008] Yuan J, et al. Systematic characterization of novel lncRNAs responding to phosphate starvation in Arabidopsis thaliana. BMC Genomics, 2016. 17: p. 655 [PMID:27538394] Linn J, et al. Root Cell-Specific Regulators of Phosphate-Dependent Growth. Plant Physiol., 2017. 174(3): p. 1969-1989 [PMID:28465462] Aleksza D,Horváth GV,Sándor G,Szabados L Proline Accumulation Is Regulated by Transcription Factors Associated with Phosphate Starvation. Plant Physiol., 2017. 175(1): p. 555-567 [PMID:28765275] Liu Y, et al. Light and Ethylene Coordinately Regulate the Phosphate Starvation Response through Transcriptional Regulation of PHOSPHATE STARVATION RESPONSE1. Plant Cell, 2017. 29(9): p. 2269-2284 [PMID:28842534] Qi W,Manfield IW,Muench SP,Baker A AtSPX1 affects the AtPHR1-DNA-binding equilibrium by binding monomeric AtPHR1 in solution. Biochem. J., 2017. 474(21): p. 3675-3687 [PMID:28887383] Huang KL, et al. The ARF7 and ARF19 Transcription Factors Positively Regulate PHOSPHATE STARVATION RESPONSE1 in Arabidopsis Roots. Plant Physiol., 2018. 178(1): p. 413-427 [PMID:30026290] Jiang M, et al. Structural basis for the Target DNA recognition and binding by the MYB domain of phosphate starvation response 1. FEBS J., 2019. [PMID:30974511]