PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_016433353.1
Organism
Nicotiana tabacum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family E2F/DP
Protein Properties Length: 374aa    MW: 42209.9 Da    PI: 9.0724
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_016433353.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP74.98.4e-24141221171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                     r+eksL+lltq+f+kl+ +++ ++++l+e+ak L+ +      +++k+RR+YDi+NVL++++ iek     ++k+++rw g
  XP_016433353.1 141 RREKSLGLLTQNFVKLFLCTDVDMICLDEAAKILLGDgrppaMTRTKVRRLYDIANVLSSMKFIEKthhpeTRKPAFRWLG 221
                     689**************************************99999*********************99999*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.9E-23136222IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013726.0E-31141221IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023196.8E-18143221IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.31E-11143222IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 374 aa     Download sequence    Send to blast
MSLASDPSKD SRSTYCRKQK SLGLLCSNFL SLYNREGIEI LLIVRFYFLK SYSSSFLLIQ  60
VLARKAKNRY SWKGFGAIPW TLQQLKEEGL KENVSGFDGS SSAKGSDDDD DDSDSKPIVS  120
SHTETLNPSS NFAAASKSDN RREKSLGLLT QNFVKLFLCT DVDMICLDEA AKILLGDGRP  180
PAMTRTKVRR LYDIANVLSS MKFIEKTHHP ETRKPAFRWL GMRERSDDKS VDTLGATESK  240
KRVFGTELTN TTIKRSRVAL PMDGISDEAT RKQLLTEVKC ENLENEIHCP KQEPGLTASK  300
KSYHFGPFAP PSLAQAEASD ADRMKRVHDW ESLASTYRPQ YHNQALKDLF AHYVEAWKSW  360
YLEVAGKNPI QLIS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A2e-20172134228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankHG9755151e-134HG975515.1 Solanum lycopersicum chromosome ch03, complete genome.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_016433353.10.0PREDICTED: E2F transcription factor-like E2FE
SwissprotQ8LSZ41e-97E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A1S3X0Y90.0A0A1S3X0Y9_TOBAC; E2F transcription factor-like E2FE
STRINGXP_009607525.10.0(Nicotiana tomentosiformis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA25222457
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.22e-98DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]