PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_009783024.1
Organism
Nicotiana sylvestris
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family E2F/DP
Protein Properties Length: 381aa    MW: 42097.5 Da    PI: 5.8332
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_009783024.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP77.41.4e-24118183171
         E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                     r ++sL+llt+kf++ll+++e+g ++ln+ a+ L   +v   +RRiYDi+NVLe+++liek+ k++i wkg
  XP_009783024.1 118 RFDNSLGLLTKKFISLLQEAEDGSLDLNHSADVL---KV--AKRRIYDITNVLEGIGLIEKTTKSRICWKG 183
                     6799******************************...88..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF467856.89E-16118181IPR011991Winged helix-turn-helix DNA-binding domain
Gene3DG3DSA:1.10.10.102.5E-25118185IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013725.3E-31118183IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023193.3E-22120183IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146601.35E-37194301No hitNo description
SuperFamilySSF1440744.71E-22195300No hitNo description
PfamPF164214.0E-21199298IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0000902Biological Processcell morphogenesis
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0042023Biological ProcessDNA endoreduplication
GO:0051782Biological Processnegative regulation of cell division
GO:0005667Cellular Componenttranscription factor complex
GO:0005730Cellular Componentnucleolus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0044212Molecular Functiontranscription regulatory region DNA binding
GO:0046982Molecular Functionprotein heterodimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 381 aa     Download sequence    Send to blast
MSTAGENVDL NLNLNLSLAP LHLMSQICSE SRPVARNLFA SSTFVSAPNN GTEKSKDDNC  60
GYGVCKTTVA ANHSPLGQAA RARAKKSSKG KASRDAISAA TGINADLLDN LNLGGSYRFD  120
NSLGLLTKKF ISLLQEAEDG SLDLNHSADV LKVAKRRIYD ITNVLEGIGL IEKTTKSRIC  180
WKGFPSTRSR GLHDQVSRLK GEIEYLNAED WRLDNCIREK LEQIRTLESD VNCQKSLLLT  240
EEDIMSLPHF RDKTVIAIKA PDASLIEVPD PCEDLDFPEK QYRLVLRSTT GPIDLFLLSK  300
QGWKHEDITI KHTKQLDALT ADEKMDDAYL SSVPPCSLDS TTSKLSGVHK IVPSHASIDD  360
DYWLRSEQEV SATDLWGIEH S
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A1e-22114184374PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1150156LKVAKRR
Functional Description ? help Back to Top
Source Description
UniProtInvolved in transcriptional repression. May act by repressing E2F-regulated genes in mature differentiated cells, but is not an antagonist of E2FA. Restricts cell division and is involved in the coordination between cell proliferation and endoreduplication during development. May play a role during the transition from skotomorphogenesis to photomorphogenesis. Regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(SKP2A) complex. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:16920782, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00190DAPTransfer from AT1G47870Download
Motif logo
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Down-regulated by light. {ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankHE6539220.0HE653922.1 Nicotiana tabacum mRNA for transcription factor E2FC (E2FC gene), cultivar Samsun nn.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009783024.10.0PREDICTED: transcription factor E2FC-like
SwissprotQ9FV701e-78E2FC_ARATH; Transcription factor E2FC
TrEMBLA0A1U7X7Y40.0A0A1U7X7Y4_NICSY; transcription factor E2FC-like
STRINGXP_009783024.10.0(Nicotiana sylvestris)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA126252022
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G47870.27e-81E2F/DP family protein
Publications ? help Back to Top
  1. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]
  2. Li B, et al.
    Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis.
    Plant Cell, 2018. 30(1): p. 178-195
    [PMID:29317470]
  3. Huntley R, et al.
    The maize retinoblastoma protein homologue ZmRb-1 is regulated during leaf development and displays conserved interactions with G1/S regulators and plant cyclin D (CycD) proteins.
    Plant Mol. Biol., 1998. 37(1): p. 155-69
    [PMID:9620273]