PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Home  TFext  BLAST  Prediction  Download  Help  About  Links  PlantRegMap
(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID XP_009770386.1
Organism
Nicotiana sylvestris
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family NAC
Protein Properties Length: 441aa    MW: 49674 Da    PI: 4.7447
Description NAC family protein
Gene Model
Gene Model ID Type Source Coding Sequence
XP_009770386.1genomeNCBIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1NAM104.71.2e-32561951128
             NAM   1 lppGfrFhPtdeelvveyLkkkvegkk.....leleevikevd....iykvePwdLpkkvkaeekewyfFskrdkkyatgkrknratk.....sg 81 
                     lp+G++F+Ptd+e++++ L k   g++     +  +e+i++vd    i++++P++Lp  vk++ +  +fF+++ k+y+tg+rk+r+++     + 
  XP_009770386.1  56 LPRGVKFDPTDQEIIWHLLGKVEVGSRsshpfI--DEFIPTVDeddgICYTHPQNLP-GVKQDGSVSHFFHRAIKAYNTGTRKRRKIHgdnfgDV 147
                     799************776665544444565332..334666544556**********.677888899******************8655555588 PP

             NAM  82 yWkatgkdkevlskkgelvglkktLvfy..kgrapkgektdWvmheyrl 128
                     +W++tg++k+v+  +g + g+kk++v+y    +  k+ekt+Wvmh+y+l
  XP_009770386.1 148 RWHKTGRTKPVIL-DGIQRGCKKIMVLYisPVKGGKAEKTNWVMHQYHL 195
                     8************.99************6545777888*********98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF1019411.96E-3842214IPR003441NAC domain
PROSITE profilePS5100530.83156214IPR003441NAC domain
PfamPF023658.1E-1457195IPR003441NAC domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0000077Biological ProcessDNA damage checkpoint
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0010332Biological Processresponse to gamma radiation
GO:0040020Biological Processregulation of meiotic nuclear division
GO:0003677Molecular FunctionDNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 441 aa     Download sequence    Send to blast
MARPSWLVDS KRIATKIKSA SGDPGAVNWK SNPTKACPKC QFIIDNNDVS NDWPGLPRGV  60
KFDPTDQEII WHLLGKVEVG SRSSHPFIDE FIPTVDEDDG ICYTHPQNLP GVKQDGSVSH  120
FFHRAIKAYN TGTRKRRKIH GDNFGDVRWH KTGRTKPVIL DGIQRGCKKI MVLYISPVKG  180
GKAEKTNWVM HQYHLGTGED EREGEYVVSK VFYQQQQQVK QGDKIEQELP EDADYLVAKV  240
DPHTPKSVTP EPPRGERISS SMDARQQIAA SSISPTTQYH DVDYTEDDMG ALPYQTENQD  300
QIIENQIDED GTKVDNETGD DPKWWDSESQ YLLDSQQLVE GLSLCDDLLA SQSPNRDEHD  360
NDTDKNKEKK CKPSLADYAQ LGPEDLKKDL EECQHLVLDP ANIDMDTPPD FRLSQLEFGS  420
QDSYIAWGGS KFGFDSGEHV G
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor regulating the transcriptional activation response to gamma irradiation (PubMed:19549833). Required for stem-cell death induced by UVB or by gamma irradiation (PubMed:20634150). Not required for ATM activation, but participates in pathways governed by both ATM and ATR sensor kinases (PubMed:19549833). Involved in DNA damage response (DDR) system that regulates cell cycle arrest (PubMed:24399300). Functional homolog of animal p53 (PubMed:24736489). Regulates SMR5 and SMR7 transcription (PubMed:24399300). Regulates DNA repair and cytokinin signaling separately and plays a key role in controlling lateral root formation under genotoxic stress. {ECO:0000269|PubMed:19549833, ECO:0000269|PubMed:20634150, ECO:0000269|PubMed:24399300, ECO:0000305|PubMed:24736489}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Not induced by zeocin or ionizing radiation treatment. {ECO:0000269|PubMed:23907539}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankHG9754441e-171HG975444.1 Solanum pennellii chromosome ch05, complete genome.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009770386.10.0PREDICTED: NAC domain-containing protein 8 isoform X2
RefseqXP_016456162.10.0PREDICTED: NAC domain-containing protein 8-like isoform X3
SwissprotQ6NQK20.0NAC8_ARATH; SUPPRESSOR OF GAMMA RESPONSE 1
TrEMBLA0A1S3YW310.0A0A1S3YW31_TOBAC; NAC domain-containing protein 8-like isoform X3
TrEMBLA0A1U7VZJ30.0A0A1U7VZJ3_NICSY; NAC domain-containing protein 8 isoform X2
STRINGXP_009770385.10.0(Nicotiana sylvestris)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G25580.11e-174NAC family protein
Publications ? help Back to Top
  1. Yi D, et al.
    The Arabidopsis SIAMESE-RELATED cyclin-dependent kinase inhibitors SMR5 and SMR7 regulate the DNA damage checkpoint in response to reactive oxygen species.
    Plant Cell, 2014. 26(1): p. 296-309
    [PMID:24399300]
  2. Biever JJ,Brinkman D,Gardner G
    UV-B inhibition of hypocotyl growth in etiolated Arabidopsis thaliana seedlings is a consequence of cell cycle arrest initiated by photodimer accumulation.
    J. Exp. Bot., 2014. 65(11): p. 2949-61
    [PMID:24591052]
  3. Hu Z,Cools T,Kalhorzadeh P,Heyman J,De Veylder L
    Deficiency of the Arabidopsis helicase RTEL1 triggers a SOG1-dependent replication checkpoint in response to DNA cross-links.
    Plant Cell, 2015. 27(1): p. 149-61
    [PMID:25595823]
  4. Chen P,Umeda M
    DNA double-strand breaks induce the expression of flavin-containing monooxygenase and reduce root meristem size in Arabidopsis thaliana.
    Genes Cells, 2015. 20(8): p. 636-46
    [PMID:26033196]
  5. Sjogren CA,Bolaris SC,Larsen PB
    Aluminum-Dependent Terminal Differentiation of the Arabidopsis Root Tip Is Mediated through an ATR-, ALT2-, and SOG1-Regulated Transcriptional Response.
    Plant Cell, 2015. 27(9): p. 2501-15
    [PMID:26320227]
  6. Yoshiyama KO
    SOG1: a master regulator of the DNA damage response in plants.
    Genes Genet. Syst., 2016. 90(4): p. 209-16
    [PMID:26617076]
  7. Weimer AK, et al.
    The plant-specific CDKB1-CYCB1 complex mediates homologous recombination repair in Arabidopsis.
    EMBO J., 2016. 35(19): p. 2068-2086
    [PMID:27497297]
  8. Davis OM,Ogita N,Inagaki S,Takahashi N,Umeda M
    DNA damage inhibits lateral root formation by up-regulating cytokinin biosynthesis genes in Arabidopsis thaliana.
    Genes Cells, 2016. 21(11): p. 1195-1208
    [PMID:27658920]
  9. Pedroza-García JA, et al.
    Function of the Plant DNA Polymerase Epsilon in Replicative Stress Sensing, a Genetic Analysis.
    Plant Physiol., 2017. 173(3): p. 1735-1749
    [PMID:28153919]
  10. Horvath BM, et al.
    Arabidopsis RETINOBLASTOMA RELATED directly regulates DNA damage responses through functions beyond cell cycle control.
    EMBO J., 2017. 36(9): p. 1261-1278
    [PMID:28320736]
  11. Sjogren CA,Larsen PB
    SUV2, which encodes an ATR-related cell cycle checkpoint and putative plant ATRIP, is required for aluminium-dependent root growth inhibition in Arabidopsis.
    Plant Cell Environ., 2017. 40(9): p. 1849-1860
    [PMID:28556304]
  12. Yoshiyama KO,Kaminoyama K,Sakamoto T,Kimura S
    Increased Phosphorylation of Ser-Gln Sites on SUPPRESSOR OF GAMMA RESPONSE1 Strengthens the DNA Damage Response in Arabidopsis thaliana.
    Plant Cell, 2017. 29(12): p. 3255-3268
    [PMID:29208704]
  13. Johnson RA, et al.
    SUPPRESSOR OF GAMMA RESPONSE1 Links DNA Damage Response to Organ Regeneration.
    Plant Physiol., 2018. 176(2): p. 1665-1675
    [PMID:29222192]
  14. Ogita N, et al.
    Identifying the target genes of SUPPRESSOR OF GAMMA RESPONSE 1, a master transcription factor controlling DNA damage response in Arabidopsis.
    Plant J., 2018. 94(3): p. 439-453
    [PMID:29430765]
  15. Cao X, et al.
    Roles of MSH2 and MSH6 in cadmium-induced G2/M checkpoint arrest in Arabidopsis roots.
    Chemosphere, 2018. 201: p. 586-594
    [PMID:29533809]