PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID NNU_016783-RA
Organism
Nelumbo nucifera
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; stem eudicotyledons; Proteales; Nelumbonaceae; Nelumbo
Family E2F/DP
Protein Properties Length: 385aa    MW: 43746.2 Da    PI: 9.7772
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
NNU_016783-RAgenomeCASView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP72.44.9e-231984171
        E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                   rk+ksL+ll+++fl+l+++   + + l+++a++L    v  +rRRiYDi+NVLe+++++++k+kn+++wkg
  NNU_016783-RA 19 RKQKSLGLLCSNFLTLYNRDGVESIGLDDAANRL---GV--ERRRIYDIVNVLESVGVLARKAKNRYSWKG 84
                   79*****************999************...**..****************************98 PP
2E2F_TDP80.71.3e-25153233171
        E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                    r+eksL+lltq+f+kl+ +s+++ ++l+e+a+ L+ +     ++++k+RR+YDi+NVL+++nliek     ++k+++rw g
  NNU_016783-RA 153 RREKSLGLLTQNFVKLFLCSNADLISLDEAARILLGDaqnssQMRTKVRRLYDIANVLSSMNLIEKthhseSRKPAFRWLG 233
                    689***************************************************************9999999******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.1E-251585IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467858.98E-161882IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.4E-271984IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023195.8E-202084IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.102.8E-24149234IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.3E-34153233IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.1E-20155233IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.77E-13155234IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 385 aa     Download sequence    Send to blast
MSSMSAFREP EARHHAYSRK QKSLGLLCSN FLTLYNRDGV ESIGLDDAAN RLGVERRRIY  60
DIVNVLESVG VLARKAKNRY SWKGFGGIPQ ALKELKEEAL RENLFNTFDA CNYGKISDDE  120
DEKSLDPNTV NGDDKSSPNS VLKPSTSSKA DNRREKSLGL LTQNFVKLFL CSNADLISLD  180
EAARILLGDA QNSSQMRTKV RRLYDIANVL SSMNLIEKTH HSESRKPAFR WLGMKGKPEN  240
GFTNLDLKDT RKRVFGADIT NTNLKRTKMV HLKDEKLNQN TKAQMQNQMD QEDLNKHIDR  300
NQAEQQSKQS SKGFVFGPFS PVGIPKVSDS DKNSSNRVQD WESLASTYRP QYHNQALSDL  360
FAHYMEAWKS WYIEVAGKKP IQQLS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A5e-40182253228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_010272101.10.0PREDICTED: E2F transcription factor-like E2FE isoform X2
SwissprotQ8LSZ41e-132E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A1U8AZA20.0A0A1U8AZA2_NELNU; E2F transcription factor-like E2FE isoform X2
STRINGXP_010272100.10.0(Nelumbo nucifera)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-127DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]