PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID NNU_011446-RA
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; stem eudicotyledons; Proteales; Nelumbonaceae; Nelumbo
Family E2F/DP
Protein Properties Length: 406aa    MW: 45148.7 Da    PI: 4.9107
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
NNU_011446-RAgenomeCASView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.91.5e-27141206171
        E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                    r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+irwkg
  NNU_011446-RA 141 RYDSSLGLLTKKFINLIKHAEDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 206
                    6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.6E-29139208IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.4E-34141206IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.18E-17141204IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.5E-24143206IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF1440749.42E-26219306No hitNo description
CDDcd146602.65E-36222306No hitNo description
PfamPF164216.7E-21244304IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 406 aa     Download sequence    Send to blast
MSGARASNRS AQPSGQILQP LKRHLPFSST KPPFVPPDDY HRFSRESRKV ADEEADAIVV  60
KSPPLKRKSE TEDCEGFNEW TTSPGYTEVV NSPLRTPVSG KGGRVYSKSK VPKHSKSGPQ  120
TPVPNAGSPS GNTLTPVGTC RYDSSLGLLT KKFINLIKHA EDGILDLNKA ADTLEVQKRR  180
IYDITNVLEG IGLIEKKLKN RIRWKGLDVS RPGEEDDDAT MLQAEVENLS MEEQRLDDRI  240
RWLFVTEEDI KGLPCFQNET LIAIKAPHGT TLEVPDPDEA VDYPQRRYRI VLRSTMGPID  300
VYLVSQFEKF EEMNSIEAPP SLPLASSSGS SENPAVAMVT EDCQGKEMEL QGHDDHRMYS  360
DPNASQDFVG GIMKIVPSDV DSDADYWLLS DAGVSITDMW KTERIT
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A6e-25136207174PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankKR8224144e-55KR822414.1 Barringtonia racemosa clone comp39641_c0 microsatellite sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_010262959.10.0PREDICTED: transcription factor E2FA-like
RefseqXP_019053996.10.0PREDICTED: transcription factor E2FA-like
SwissprotQ9FNY01e-148E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A1U8Q7H70.0A0A1U8Q7H7_NELNU; transcription factor E2FA-like
STRINGXP_010262959.10.0(Nelumbo nucifera)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-145E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]