PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

NNU_002898-RA

Organism

Nelumbo nucifera

Taxonomic ID

4432

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; stem eudicotyledons; Proteales; Nelumbonaceae; Nelumbo

Family

NAC

Protein Properties

Length: 388aa MW: 43735.1 Da PI: 6.6008

Description

NAC family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
NNU_002898-RA	genome	CAS	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	NAM	96.3	4.8e-30	55	197	1	128
NAM 1 lppGfrFhPtdeelvveyLkkkvegkk......leleevikevd....iykvePwdLpkkvkaeekewyfFskrdkkyatgkrknra........t 78 lp+G++F+P+d el+ e+L+ kv + + +e i++++ iy+++P++Lp +k++ +++yfF++++++y+ g+rk+r+ NNU_002898-RA 55 LPAGVKFDPSDVELL-EHLAGKVGVGDsephlfI--DELIPTLEgnegIYYTHPENLP-GAKKDGSSVYFFHRTANAYSIGHRKRRKihhqcnkgE 146 799**********.99987775666432..333444423344******.55677899***************8567766655 PP NAM 79 ksgyWkatgkdkevlskkgelvglkktLvfy..kgrapkgektdWvmheyrl 128 ++ +W++tgk+k+v++ +g ++g kk++v+y +++ +k+ k +Wvmh+y+l NNU_002898-RA 147 EHVRWHKTGKTKPVVE-NGMQKGFKKIMVLYksSKKGSKPDKYNWVMHQYHL 197 5889********.999*******4434666777*******98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF101941	2.09E-35	39	216	IPR003441	NAC domain
PROSITE profile	PS51005	30.579	55	216	IPR003441	NAC domain
Pfam	PF02365	1.2E-13	56	197	IPR003441	NAC domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 388 aa Download sequence Send to blast
MVKSWLIDGR GIAAKVKNAT QFSSHQVKDL GANRQCPNCH HHIDNSDVSL EWPGLPAGVK 60 FDPSDVELLE HLAGKVGVGD SEPHLFIDEL IPTLEGNEGI YYTHPENLPG AKKDGSSVYF 120 FHRTANAYSI GHRKRRKIHH QCNKGEEHVR WHKTGKTKPV VENGMQKGFK KIMVLYKSSK 180 KGSKPDKYNW VMHQYHLGTE NDEKEGQYVV SKIFYQQKKK HTDKSDAEIE MVQASPRTPK 240 TKTPDIRQPR KGALCDVINE EKETEFIENA PQPPLSAVSL DDDRLDPAWW AGESQPVEDP 300 DPNAMDDLLL CNEIFDSYTP IDNSVGLSDL SCHRNDALTD VNTASGIPNL DDVEIGSAVW 360 FARKYYGLVR PTIESGHDLS FKTKYCFI

Sequence ? help Back to Top

Protein Sequence Length: 388 aa Download sequence Send to blast

MVKSWLIDGR GIAAKVKNAT QFSSHQVKDL GANRQCPNCH HHIDNSDVSL EWPGLPAGVK  60
FDPSDVELLE HLAGKVGVGD SEPHLFIDEL IPTLEGNEGI YYTHPENLPG AKKDGSSVYF  120
FHRTANAYSI GHRKRRKIHH QCNKGEEHVR WHKTGKTKPV VENGMQKGFK KIMVLYKSSK  180
KGSKPDKYNW VMHQYHLGTE NDEKEGQYVV SKIFYQQKKK HTDKSDAEIE MVQASPRTPK  240
TKTPDIRQPR KGALCDVINE EKETEFIENA PQPPLSAVSL DDDRLDPAWW AGESQPVEDP  300
DPNAMDDLLL CNEIFDSYTP IDNSVGLSDL SCHRNDALTD VNTASGIPNL DDVEIGSAVW  360
FARKYYGLVR PTIESGHDLS FKTKYCFI

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor regulating the transcriptional activation response to gamma irradiation (PubMed:19549833). Required for stem-cell death induced by UVB or by gamma irradiation (PubMed:20634150). Not required for ATM activation, but participates in pathways governed by both ATM and ATR sensor kinases (PubMed:19549833). Involved in DNA damage response (DDR) system that regulates cell cycle arrest (PubMed:24399300). Functional homolog of animal p53 (PubMed:24736489). Regulates SMR5 and SMR7 transcription (PubMed:24399300). Regulates DNA repair and cytokinin signaling separately and plays a key role in controlling lateral root formation under genotoxic stress. {ECO:0000269\|PubMed:19549833, ECO:0000269\|PubMed:20634150, ECO:0000269\|PubMed:24399300, ECO:0000305\|PubMed:24736489}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Not induced by zeocin or ionizing radiation treatment. {ECO:0000269\|PubMed:23907539}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_010248662.1	0.0	PREDICTED: NAC domain-containing protein 73-like isoform X2
Swissprot	Q6NQK2	2e-79	NAC8_ARATH; SUPPRESSOR OF GAMMA RESPONSE 1
TrEMBL	A0A1U7ZJZ6	0.0	A0A1U7ZJZ6_NELNU; NAC domain-containing protein 73-like isoform X2
STRING	XP_010248661.1	0.0	(Nelumbo nucifera)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G01600.1	2e-93	NAC domain containing protein 44

Publications ? help Back to Top
Yi D, et al. The Arabidopsis SIAMESE-RELATED cyclin-dependent kinase inhibitors SMR5 and SMR7 regulate the DNA damage checkpoint in response to reactive oxygen species. Plant Cell, 2014. 26(1): p. 296-309 [PMID:24399300] Biever JJ,Brinkman D,Gardner G UV-B inhibition of hypocotyl growth in etiolated Arabidopsis thaliana seedlings is a consequence of cell cycle arrest initiated by photodimer accumulation. J. Exp. Bot., 2014. 65(11): p. 2949-61 [PMID:24591052] Hu Z,Cools T,Kalhorzadeh P,Heyman J,De Veylder L Deficiency of the Arabidopsis helicase RTEL1 triggers a SOG1-dependent replication checkpoint in response to DNA cross-links. Plant Cell, 2015. 27(1): p. 149-61 [PMID:25595823] Chen P,Umeda M DNA double-strand breaks induce the expression of flavin-containing monooxygenase and reduce root meristem size in Arabidopsis thaliana. Genes Cells, 2015. 20(8): p. 636-46 [PMID:26033196] Sjogren CA,Bolaris SC,Larsen PB Aluminum-Dependent Terminal Differentiation of the Arabidopsis Root Tip Is Mediated through an ATR-, ALT2-, and SOG1-Regulated Transcriptional Response. Plant Cell, 2015. 27(9): p. 2501-15 [PMID:26320227] Yoshiyama KO SOG1: a master regulator of the DNA damage response in plants. Genes Genet. Syst., 2016. 90(4): p. 209-16 [PMID:26617076] Weimer AK, et al. The plant-specific CDKB1-CYCB1 complex mediates homologous recombination repair in Arabidopsis. EMBO J., 2016. 35(19): p. 2068-2086 [PMID:27497297] Davis OM,Ogita N,Inagaki S,Takahashi N,Umeda M DNA damage inhibits lateral root formation by up-regulating cytokinin biosynthesis genes in Arabidopsis thaliana. Genes Cells, 2016. 21(11): p. 1195-1208 [PMID:27658920] Pedroza-García JA, et al. Function of the Plant DNA Polymerase Epsilon in Replicative Stress Sensing, a Genetic Analysis. Plant Physiol., 2017. 173(3): p. 1735-1749 [PMID:28153919] Horvath BM, et al. Arabidopsis RETINOBLASTOMA RELATED directly regulates DNA damage responses through functions beyond cell cycle control. EMBO J., 2017. 36(9): p. 1261-1278 [PMID:28320736] Sjogren CA,Larsen PB SUV2, which encodes an ATR-related cell cycle checkpoint and putative plant ATRIP, is required for aluminium-dependent root growth inhibition in Arabidopsis. Plant Cell Environ., 2017. 40(9): p. 1849-1860 [PMID:28556304] Yoshiyama KO,Kaminoyama K,Sakamoto T,Kimura S Increased Phosphorylation of Ser-Gln Sites on SUPPRESSOR OF GAMMA RESPONSE1 Strengthens the DNA Damage Response in Arabidopsis thaliana. Plant Cell, 2017. 29(12): p. 3255-3268 [PMID:29208704] Johnson RA, et al. SUPPRESSOR OF GAMMA RESPONSE1 Links DNA Damage Response to Organ Regeneration. Plant Physiol., 2018. 176(2): p. 1665-1675 [PMID:29222192] Ogita N, et al. Identifying the target genes of SUPPRESSOR OF GAMMA RESPONSE 1, a master transcription factor controlling DNA damage response in Arabidopsis. Plant J., 2018. 94(3): p. 439-453 [PMID:29430765] Cao X, et al. Roles of MSH2 and MSH6 in cadmium-induced G2/M checkpoint arrest in Arabidopsis roots. Chemosphere, 2018. 201: p. 586-594 [PMID:29533809]