PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID NNU_002573-RA
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; stem eudicotyledons; Proteales; Nelumbonaceae; Nelumbo
Family E2F/DP
Protein Properties Length: 466aa    MW: 51611.5 Da    PI: 4.6906
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
NNU_002573-RAgenomeCASView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.61.8e-27142207171
        E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                    r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+irwkg
  NNU_002573-RA 142 RYDSSLGLLTKKFINLIKHAEDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 207
                    6899******************************...99..****************************98 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.104.5E-29140209IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467854.44E-17142205IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.4E-34142207IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.9E-24144207IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146609.39E-49218324No hitNo description
SuperFamilySSF1440741.83E-34219324No hitNo description
PfamPF164217.3E-34223322IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0010090Biological Processtrichome morphogenesis
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051302Biological Processregulation of cell division
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 466 aa     Download sequence    Send to blast
MSGARASNRS AQPSGQILQP LKRHLPFSST KPPFVPPDDY HRFSGDNRRV ANEEAEAIVV  60
KSPPLKRKSE AEDCEGESSE WTTSPGYTEV VNSPLRTPVS GKGGRVYSKS KVPKHGRSGP  120
QTPVSNAGSP SGNTLTPVGT CRYDSSLGLL TKKFINLIKH AEDGILDLNK AADTLEVQKR  180
RIYDITNVLE GIGLIEKKLK NRIRWKGLDV SKPGEADDDV ANLQAEVENL SLKEQRLDDR  240
IREMQERLRD LSEDENNQKW LFVTEEDIKG LPCFQNETLI AIKAPHGTTL EVPDPDEAVD  300
YPQRRYRIVL RSTMGPIDVY LVSQFEEKFE EMNGVEAPQS LPLPSSSGSN ENPAAITVTE  360
DNSGREMELQ GNDAHRIYSD PNASHDFVSG IMKIVPSDVD SDADYWLLSD AGVSITDMWK  420
TEPGVEWDTV DPLHPEEFVM ADVSTPRPQT PPSGVIEVPS SNSIQR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A1e-24137208174PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00661PBMTransfer from Pp3c1_6880Download
Motif logo
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_010246568.10.0PREDICTED: transcription factor E2FA
SwissprotQ9FNY01e-166E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A1U7ZG990.0A0A1U7ZG99_NELNU; transcription factor E2FA
STRINGXP_010246568.10.0(Nelumbo nucifera)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-163E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]