PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Niben101Scf11512g01005.1

Organism

Nicotiana benthamiana

Taxonomic ID

4100

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana

Family

HSF

Protein Properties

Length: 350aa MW: 40595.6 Da PI: 5.352

Description

HSF family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Niben101Scf11512g01005.1	genome	BTI	-

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HSF_DNA-bind	109	3.6e-34	59	151	2	103
HHHHHHHHHCTGGGTTTSEESSSSSEEEES-HHHHHHHTHHHHSTT--HHHHHHHHHHTTEEE---SSBTTTTXTTSEEEEESXX CS HSF_DNA-bind 2 FlkklyeiledeelkeliswsengnsfvvldeeefakkvLpkyFkhsnfaSFvRQLnmYgFkkvkdeekkskskekiweFkhksF 86 Flkk++e+++d++++++isws++++sfvv+d+++f+ ++Lpk+Fkh+nf+SF+RQLn+Y F+k+++++ weF+++ F Niben101Scf11512g01005.1 59 FLKKTFEMVDDPNTDSIISWSNTKTSFVVWDPHKFSIDLLPKHFKHNNFSSFIRQLNTYRFRKIDSDR---------WEFANEGF 134 9******************999*************************************999.........**** PP XXXXXXXXXXXXXXXXX CS HSF_DNA-bind 87 kkgkkellekikrkkse 103 +kgkk+ll +ikr+k++ Niben101Scf11512g01005.1 135 QKGKKHLLINIKRRKQQ 151 ************986 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SMART	SM00415	1.0E-53	55	148	IPR000232	Heat shock factor (HSF)-type, DNA-binding
Gene3D	G3DSA:1.10.10.10	1.4E-37	55	148	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	3.63E-34	55	148	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF00447	1.3E-30	59	148	IPR000232	Heat shock factor (HSF)-type, DNA-binding
PRINTS	PR00056	8.5E-18	59	82	IPR000232	Heat shock factor (HSF)-type, DNA-binding
PRINTS	PR00056	8.5E-18	97	109	IPR000232	Heat shock factor (HSF)-type, DNA-binding
PROSITE pattern	PS00434	0	98	122	IPR000232	Heat shock factor (HSF)-type, DNA-binding
PRINTS	PR00056	8.5E-18	110	122	IPR000232	Heat shock factor (HSF)-type, DNA-binding

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0043565	Molecular Function	sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 350 aa Download sequence Send to blast
MEQEKMVTDD VINGGLQTVK EEPVLFLDEE DDIIGNSEFS SSLLPKPLEG LRDMGPPPFL 60 KKTFEMVDDP NTDSIISWSN TKTSFVVWDP HKFSIDLLPK HFKHNNFSSF IRQLNTYRFR 120 KIDSDRWEFA NEGFQKGKKH LLINIKRRKQ QYTHQGSGSA QSWLGSCNKD GIEAELEKLK 180 KDQNTLKMEV QSLKQQQEST ESYLATVKER LQNSETRQKY MVIFMAKAFK NPLFVQHLIE 240 KIKQRKTLDN GTLTKKRRLA SNPCDNQCDG HSLQVQEEFT TIKSEIQTLF SSDESNSPAD 300 EQKRNSQDMS SENYILWEKL MEDDMIYENG AENDKHHSDI VLELEDLIAS

Sequence ? help Back to Top

Protein Sequence Length: 350 aa Download sequence Send to blast

MEQEKMVTDD VINGGLQTVK EEPVLFLDEE DDIIGNSEFS SSLLPKPLEG LRDMGPPPFL  60
KKTFEMVDDP NTDSIISWSN TKTSFVVWDP HKFSIDLLPK HFKHNNFSSF IRQLNTYRFR  120
KIDSDRWEFA NEGFQKGKKH LLINIKRRKQ QYTHQGSGSA QSWLGSCNKD GIEAELEKLK  180
KDQNTLKMEV QSLKQQQEST ESYLATVKER LQNSETRQKY MVIFMAKAFK NPLFVQHLIE  240
KIKQRKTLDN GTLTKKRRLA SNPCDNQCDG HSLQVQEEFT TIKSEIQTLF SSDESNSPAD  300
EQKRNSQDMS SENYILWEKL MEDDMIYENG AENDKHHSDI VLELEDLIAS

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5d5u_B	3e-22	57	148	27	129	Heat shock factor protein 1
5d5v_B	3e-22	57	148	27	129	Heat shock factor protein 1
5d5v_D	3e-22	57	148	27	129	Heat shock factor protein 1
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). Involved in heat stress responses. Seems to be involved in other environmental stress responses. Activates ascorbate peroxidase 2 (APX2) in addition to several heat shock protein (HSPs). {ECO:0000269\|PubMed:16649111, ECO:0000269\|PubMed:17059409, ECO:0000269\|PubMed:17085506}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By heat stress, high light and hydrogen peroxide (H(2)O(2)). {ECO:0000269\|PubMed:16649111, ECO:0000269\|PubMed:17059409, ECO:0000269\|PubMed:17085506}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_009606363.1	0.0	PREDICTED: heat stress transcription factor A-7a-like
Swissprot	O80982	1e-84	HSFA2_ARATH; Heat stress transcription factor A-2
TrEMBL	A0A1S4CRR3	0.0	A0A1S4CRR3_TOBAC; heat stress transcription factor A-7a-like
STRING	XP_009606363.1	0.0	(Nicotiana tomentosiformis)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA5681	22	35

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G26150.1	5e-87	heat shock transcription factor A2

Publications ? help Back to Top
Liu HC,Charng YY Common and distinct functions of Arabidopsis class A1 and A2 heat shock factors in diverse abiotic stress responses and development. Plant Physiol., 2013. 163(1): p. 276-90 [PMID:23832625] Jung HS, et al. Subset of heat-shock transcription factors required for the early response of Arabidopsis to excess light. Proc. Natl. Acad. Sci. U.S.A., 2013. 110(35): p. 14474-9 [PMID:23918368] Chauhan H,Khurana N,Agarwal P,Khurana JP,Khurana P A seed preferential heat shock transcription factor from wheat provides abiotic stress tolerance and yield enhancement in transgenic Arabidopsis under heat stress environment. PLoS ONE, 2013. 8(11): p. e79577 [PMID:24265778] Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Weng M, et al. Histone chaperone ASF1 is involved in gene transcription activation in response to heat stress in Arabidopsis thaliana. Plant Cell Environ., 2014. 37(9): p. 2128-38 [PMID:24548003] Jang YH, et al. A homolog of splicing factor SF1 is essential for development and is involved in the alternative splicing of pre-mRNA in Arabidopsis thaliana. Plant J., 2014. 78(4): p. 591-603 [PMID:24580679] Stief A, et al. Arabidopsis miR156 Regulates Tolerance to Recurring Environmental Stress through SPL Transcription Factors. Plant Cell, 2014. 26(4): p. 1792-1807 [PMID:24769482] Dobrá J, et al. The impact of heat stress targeting on the hormonal and transcriptomic response in Arabidopsis. Plant Sci., 2015. 231: p. 52-61 [PMID:25575991] Yamauchi Y,Kunishima M,Mizutani M,Sugimoto Y Reactive short-chain leaf volatiles act as powerful inducers of abiotic stress-related gene expression. Sci Rep, 2015. 5: p. 8030 [PMID:25619826] Shi H, et al. Melatonin induces class A1 heat-shock factors (HSFA1s) and their possible involvement of thermotolerance in Arabidopsis. J. Pineal Res., 2015. 58(3): p. 335-42 [PMID:25711624] Mueller SP,Krause DM,Mueller MJ,Fekete A Accumulation of extra-chloroplastic triacylglycerols in Arabidopsis seedlings during heat acclimation. J. Exp. Bot., 2015. 66(15): p. 4517-26 [PMID:25977236] Nie S,Yue H,Xing D A Potential Role for Mitochondrial Produced Reactive Oxygen Species in Salicylic Acid-Mediated Plant Acquired Thermotolerance. Plant Physiol., 2016. [PMID:26099269] Nguyen AH, et al. Loss of Arabidopsis 5'-3' Exoribonuclease AtXRN4 Function Enhances Heat Stress Tolerance of Plants Subjected to Severe Heat Stress. Plant Cell Physiol., 2015. 56(9): p. 1762-72 [PMID:26136597] Hu Z, et al. Histone acetyltransferase GCN5 is essential for heat stress-responsive gene activation and thermotolerance in Arabidopsis. Plant J., 2015. 84(6): p. 1178-91 [PMID:26576681] Lämke J,Brzezinka K,Bäurle I HSFA2 orchestrates transcriptional dynamics after heat stress in Arabidopsis thaliana. Transcription, 2016. 7(4): p. 111-4 [PMID:27383578] Wang X,Huang W,Liu J,Yang Z,Huang B Molecular regulation and physiological functions of a novel FaHsfA2c cloned from tall fescue conferring plant tolerance to heat stress. Plant Biotechnol. J., 2017. 15(2): p. 237-248 [PMID:27500592] Chen ST,He NY,Chen JH,Guo FQ Identification of core subunits of photosystem II as action sites of HSP21, which is activated by the GUN5-mediated retrograde pathway in Arabidopsis. Plant J., 2017. 89(6): p. 1106-1118 [PMID:27943531] Kataoka R,Takahashi M,Suzuki N Coordination between bZIP28 and HSFA2 in the regulation of heat response signals in Arabidopsis. Plant Signal Behav, 2017. 12(11): p. e1376159 [PMID:28873003] Wang X,Zhuang L,Shi Y,Huang B Up-Regulation of HSFA2c and HSPs by ABA Contributing to Improved Heat Tolerance in Tall Fescue and Arabidopsis. Int J Mol Sci, 2018. [PMID:28914758] Llamas E,Pulido P,Rodriguez-Concepcion M Interference with plastome gene expression and Clp protease activity in Arabidopsis triggers a chloroplast unfolded protein response to restore protein homeostasis. PLoS Genet., 2017. 13(9): p. e1007022 [PMID:28937985] Li X, et al. Plastid Translation Elongation Factor Tu Is Prone to Heat-Induced Aggregation Despite Its Critical Role in Plant Heat Tolerance. Plant Physiol., 2018. 176(4): p. 3027-3045 [PMID:29444814]