PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Niben101Scf03208g07011.1
Organism
Nicotiana benthamiana
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family bHLH
Protein Properties Length: 180aa    MW: 20548 Da    PI: 5.3846
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Niben101Scf03208g07011.1genomeBTI-
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH20.77.6e-074766120
                              CHHHHHHHHHHHHHHHHHHH CS
                       HLH  1 rrrahnerErrRRdriNsaf 20
                              +r++hne+Er+RR+++N+ +
  Niben101Scf03208g07011.1 47 QRMTHNEVERNRRKQMNEHL 66
                              79***************976 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF474594.32E-1045110IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.103.2E-44566IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000837.17E-74589No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 180 aa     Download sequence    Send to blast
MEEKENNQNA AQLRFLIGEN LENGKANENK KKRKRTRIKS SEEVENQRMT HNEVERNRRK  60
QMNEHLLGDQ ASIIGGAIEF VRELEQLLQC LESQKRRKLY GDDHLSTSSM EIHQNPSQPQ  120
FCAPLPLANE LYEGGIQEEI AEIKSCLADV EISGETKFTA DGIANLIQQI FSFIHANNAI
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
13035KKRKRT
24758RMTHNEVERNRR
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_009628530.15e-71PREDICTED: transcription factor FAMA-like isoform X2
RefseqXP_009628531.15e-71PREDICTED: transcription factor FAMA-like isoform X2
RefseqXP_009628533.15e-71PREDICTED: transcription factor FAMA-like isoform X2
RefseqXP_018634011.17e-71PREDICTED: transcription factor FAMA-like isoform X1
SwissprotQ56YJ84e-37FAMA_ARATH; Transcription factor FAMA
TrEMBLA0A1S4B4M14e-69A0A1S4B4M1_TOBAC; transcription factor FAMA-like isoform X2
TrEMBLA0A1S4B4U94e-69A0A1S4B4U9_TOBAC; transcription factor FAMA-like isoform X1
TrEMBLA0A1U7VRL44e-69A0A1U7VRL4_NICSY; transcription factor FAMA-like
STRINGXP_009628530.12e-70(Nicotiana tomentosiformis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA46572341
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G24140.18e-24bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Matos JL, et al.
    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
    Elife, 2015.
    [PMID:25303364]
  3. Chen L, et al.
    NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.
    Development, 2016. 143(9): p. 1600-11
    [PMID:26989174]
  4. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  5. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]
  6. Li X,Yang R,Chen H
    The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
    PLoS ONE, 2018. 13(3): p. e0193458
    [PMID:29513733]