PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Niben101Scf01171g08002.1

Organism

Nicotiana benthamiana

Taxonomic ID

4100

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana

Family

bHLH

Protein Properties

Length: 355aa MW: 40465.6 Da PI: 6.4162

Description

bHLH family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Niben101Scf01171g08002.1	genome	BTI	-

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	29.1	1.8e-09	179	214	1	36
CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS CS HLH 1 rrrahnerErrRRdriNsafeeLrellPkaskapsk 36 +r++h ++Er+RR+++N+ + Lr+l+P ++ ++s+ Niben101Scf01171g08002.1 179 QRMTHIAVERNRRKQMNEHLRVLRSLMPGSYVQRSQ 214 79**************************96534444 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:4.10.280.10	7.9E-9	177	214	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
CDD	cd00083	1.08E-6	177	212	No hit	No description
PROSITE profile	PS50888	9.477	178	256	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamily	SSF47459	2.76E-8	178	215	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Pfam	PF00010	8.3E-7	179	215	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
CDD	cd04873	5.42E-4	281	345	No hit	No description
SuperFamily	SSF55021	4.5E-5	281	346	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0046983	Molecular Function	protein dimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 355 aa Download sequence Send to blast
MEKRENSQAS LPTTFQMVGE TSHVANNTNQ MVDYLLNSHS VQQQQQQQQQ QQHENSLGFC 60 PSGTSLDKLS FADVMQFADF GPKLALNQAK VSEEDARIDP VYFLKFPVLN EKTLQDDDQE 120 TLMVQQKEDQ KFKVIEEKAN TSMQLPYAGE NIERSPGNEG KSNKRKRPRV KTTEEVESQR 180 MTHIAVERNR RKQMNEHLRV LRSLMPGSYV QRSQKRRRLY GDNGPRPLGD NSSIQNPNTP 240 LQPIIFPLPN DYIEAGIQEE IAESKSCLAD VEVKLLGFDA MIKILSRRRP GQLIKTIAAL 300 EDMQLNILHT NITTIEQTVL YSFNVKISGE TRYTADDIAN SIQQIFSFIH ADSPI

Sequence ? help Back to Top

Protein Sequence Length: 355 aa Download sequence Send to blast

MEKRENSQAS LPTTFQMVGE TSHVANNTNQ MVDYLLNSHS VQQQQQQQQQ QQHENSLGFC  60
PSGTSLDKLS FADVMQFADF GPKLALNQAK VSEEDARIDP VYFLKFPVLN EKTLQDDDQE  120
TLMVQQKEDQ KFKVIEEKAN TSMQLPYAGE NIERSPGNEG KSNKRKRPRV KTTEEVESQR  180
MTHIAVERNR RKQMNEHLRV LRSLMPGSYV QRSQKRRRLY GDNGPRPLGD NSSIQNPNTP  240
LQPIIFPLPN DYIEAGIQEE IAESKSCLAD VEVKLLGFDA MIKILSRRRP GQLIKTIAAL  300
EDMQLNILHT NITTIEQTVL YSFNVKISGE TRYTADDIAN SIQQIFSFIH ADSPI

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	179	190	RMTHIAVERNRR
2	214	218	KRRRL

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269\|PubMed:17088607, ECO:0000269\|PubMed:17183265, ECO:0000269\|PubMed:17183267, ECO:0000269\|PubMed:24571519, ECO:0000269\|PubMed:24654956}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269\|PubMed:22442411}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_009795997.1	0.0	PREDICTED: transcription factor FAMA isoform X1
Refseq	XP_016459961.1	0.0	PREDICTED: transcription factor FAMA-like isoform X1
Swissprot	Q56YJ8	1e-108	FAMA_ARATH; Transcription factor FAMA
TrEMBL	A0A1S3Z6F0	0.0	A0A1S3Z6F0_TOBAC; transcription factor FAMA-like isoform X1
TrEMBL	A0A1U7XVF9	0.0	A0A1U7XVF9_NICSY; transcription factor FAMA isoform X1
STRING	XP_009795997.1	0.0	(Nicotiana sylvestris)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA4657	23	41

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G24140.1	1e-109	bHLH family protein

Publications ? help Back to Top
Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature. Differentiation, 2010. 80(1): p. 1-8 [PMID:20219281] Matos JL, et al. Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module. Elife, 2015. [PMID:25303364] Chen L, et al. NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis. Development, 2016. 143(9): p. 1600-11 [PMID:26989174] Lee JH,Jung JH,Park CM Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis. Plant Cell, 2017. 29(11): p. 2817-2830 [PMID:29070509] Han X, et al. Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons. Plant Physiol., 2018. 176(4): p. 2871-2885 [PMID:29496884] Li X,Yang R,Chen H The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA. PLoS ONE, 2018. 13(3): p. e0193458 [PMID:29513733]