PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Medtr8g463380.1

Common Name

MTR_8g463380

Organism

Medicago truncatula

Taxonomic ID

3880

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Trifolieae; Medicago

Family

TCP

Protein Properties

Length: 434aa MW: 47448.6 Da PI: 7.1518

Description

TCP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Medtr8g463380.1	genome	Mt	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	TCP	121.3	1.2e-37	52	163	2	89
TCP 2 agkkdrhskihTkvggRdRRvRlsaecaarfFdLqdeLGfdkdsktieWLlqqakpaikeltgtssssasec...eaesssssasnsssg.... 88 +g+kdrhsk++T++g+RdRRvRlsa++a++f+d+qd+LG+d++sk+++WL+++ak ai+el+ +++ +++++ + +++++++ ++ Medtr8g463380.1 52 TGRKDRHSKVCTAKGPRDRRVRLSAHTAIQFYDVQDRLGYDRPSKAVDWLIKKAKSAIDELAHLPAWNPTATcssT--PQQQQQQQTNEMfhrq 143 79**************************************************************555553332322..2222222222222233 PP TCP 89 ...................k 89 + Medtr8g463380.1 144 spvdnnpvtastshrsaalE 163 33333333333222221111 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Pfam	PF03634	1.6E-30	52	171	IPR005333	Transcription factor, TCP
PROSITE profile	PS51369	34.187	54	112	IPR017887	Transcription factor TCP subgroup

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0009793	Biological Process	embryo development ending in seed dormancy
GO:0009965	Biological Process	leaf morphogenesis
GO:0030154	Biological Process	cell differentiation
GO:0045962	Biological Process	positive regulation of development, heterochronic
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 434 aa Download sequence Send to blast
MGETIHDQHT GTATATATTT KTAATTSSKR ISSSGGGGEI VEVQGGHIVR STGRKDRHSK 60 VCTAKGPRDR RVRLSAHTAI QFYDVQDRLG YDRPSKAVDW LIKKAKSAID ELAHLPAWNP 120 TATCSSTPQQ QQQQQTNEMF HRQSPVDNNP VTASTSHRSA ALERRMPPHE QQFPSQQQQL 180 EIDYNSSSSG KHGFLQGSLD TDIADTIKSF FPVETPTTSF HNYQQPPDLL SRTAATTQQQ 240 DLRLSLQSFQ DPIMLQSHHD NHHHHHNNNN QVLFAGNSSL GYDGGGSGST LWSEQQQQQQ 300 HQEEHDNGRL NRMMAWNANN INANAADGGN SGHGAGFVFS TPAPAFGGYG QFFTQRGPLQ 360 SSYNPSVRAW IDPSMATANI VDHHHHYLSP MIHQASVSGG GFSGFRIPAR IQGEEEHDGV 420 SDKPSSASSD SRH*

Sequence ? help Back to Top

Protein Sequence Length: 434 aa Download sequence Send to blast

MGETIHDQHT GTATATATTT KTAATTSSKR ISSSGGGGEI VEVQGGHIVR STGRKDRHSK  60
VCTAKGPRDR RVRLSAHTAI QFYDVQDRLG YDRPSKAVDW LIKKAKSAID ELAHLPAWNP  120
TATCSSTPQQ QQQQQTNEMF HRQSPVDNNP VTASTSHRSA ALERRMPPHE QQFPSQQQQL  180
EIDYNSSSSG KHGFLQGSLD TDIADTIKSF FPVETPTTSF HNYQQPPDLL SRTAATTQQQ  240
DLRLSLQSFQ DPIMLQSHHD NHHHHHNNNN QVLFAGNSSL GYDGGGSGST LWSEQQQQQQ  300
HQEEHDNGRL NRMMAWNANN INANAADGGN SGHGAGFVFS TPAPAFGGYG QFFTQRGPLQ  360
SSYNPSVRAW IDPSMATANI VDHHHHYLSP MIHQASVSGG GFSGFRIPAR IQGEEEHDGV  420
SDKPSSASSD SRH*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5zkt_A	1e-20	59	112	1	54	Putative transcription factor PCF6
5zkt_B	1e-20	59	112	1	54	Putative transcription factor PCF6
Search in ModeBase

Expression -- Description ? help Back to Top
Source	Description
Uniprot	DEVELOPMENTAL STAGE: Expressed in cotyledons during embryogenesis. Expressed during ovule development (PubMed:25378179). {ECO:0000269\|PubMed:25378179}.
Uniprot	TISSUE SPECIFICITY: Expressed in cotyledons, particularly in the vascular region, in leaves, roots, buds, flowers and immature siliques. {ECO:0000269\|PubMed:17307931}.

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor playing a pivotal role in the control of morphogenesis of shoot organs by negatively regulating the expression of boundary-specific genes such as CUC genes, probably through the induction of miRNA (e.g. miR164) (PubMed:12931144, PubMed:17307931). Required during early steps of embryogenesis (PubMed:15634699). Participates in ovule develpment (PubMed:25378179). Activates LOX2 expression by binding to the 5'-GGACCA-3' motif found in its promoter (PubMed:18816164). {ECO:0000269\|PubMed:12931144, ECO:0000269\|PubMed:15634699, ECO:0000269\|PubMed:17307931, ECO:0000269\|PubMed:18816164, ECO:0000269\|PubMed:25378179}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00009	PBM	Transfer from 929286	Download

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Medtr8g463380.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Repressed by the miRNA miR-JAW/miR319 (PubMed:12931144, PubMed:18816164). {ECO:0000269\|PubMed:12931144, ECO:0000269\|PubMed:18816164}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_013445507.1	0.0	transcription factor TCP4
Swissprot	Q8LPR5	8e-96	TCP4_ARATH; Transcription factor TCP4
TrEMBL	A0A072TRR1	0.0	A0A072TRR1_MEDTR; Putative transcription factor TCP family
STRING	XP_004510040.1	0.0	(Cicer arietinum)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF1163	34	105

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G15030.3	1e-77	TCP family protein

Link Out ? help Back to Top
Phytozome	Medtr8g463380.1
Entrez Gene	25502512

Publications ? help Back to Top
Schommer C, et al. Control of jasmonate biosynthesis and senescence by miR319 targets. PLoS Biol., 2008. 6(9): p. e230 [PMID:18816164] Young ND, et al. The Medicago genome provides insight into the evolution of rhizobial symbioses. Nature, 2011. 480(7378): p. 520-4 [PMID:22089132] Ju Y, et al. Arabidopsis JINGUBANG Is a Negative Regulator of Pollen Germination That Prevents Pollination in Moist Environments. Plant Cell, 2016. 28(9): p. 2131-2146 [PMID:27468890] Challa KR,Aggarwal P,Nath U Activation of YUCCA5 by the Transcription Factor TCP4 Integrates Developmental and Environmental Signals to Promote Hypocotyl Elongation in Arabidopsis. Plant Cell, 2016. 28(9): p. 2117-2130 [PMID:27597774] Alvarez JP,Furumizu C,Efroni I,Eshed Y,Bowman JL Active suppression of a leaf meristem orchestrates determinate leaf growth. Elife, 2017. [PMID:27710768] Li J, et al. RABBIT EARS regulates the transcription of TCP4 during petal development in Arabidopsis. J. Exp. Bot., 2016. 67(22): p. 6473-6480 [PMID:27838638] Sun X, et al. Activation of secondary cell wall biosynthesis by miR319-targeted TCP4 transcription factor. Plant Biotechnol. J., 2017. 15(10): p. 1284-1294 [PMID:28233945] Kubota A, et al. TCP4-dependent induction of CONSTANS transcription requires GIGANTEA in photoperiodic flowering in Arabidopsis. PLoS Genet., 2017. 13(6): p. e1006856 [PMID:28628608] Koyama T,Sato F,Ohme-Takagi M Roles of miR319 and TCP Transcription Factors in Leaf Development. Plant Physiol., 2017. 175(2): p. 874-885 [PMID:28842549] Bresso EG,Chorostecki U,Rodriguez RE,Palatnik JF,Schommer C Spatial Control of Gene Expression by miR319-Regulated TCP Transcription Factors in Leaf Development. Plant Physiol., 2018. 176(2): p. 1694-1708 [PMID:29133375] Vadde BVL,Challa KR,Nath U The TCP4 transcription factor regulates trichome cell differentiation by directly activating GLABROUS INFLORESCENCE STEMS in Arabidopsis thaliana. Plant J., 2018. 93(2): p. 259-269 [PMID:29165850] Challa KR,Rath M,Nath U The CIN-TCP transcription factors promote commitment to differentiation in Arabidopsis leaf pavement cells via both auxin-dependent and independent pathways. PLoS Genet., 2019. 15(2): p. e1007988 [PMID:30742619]