PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Medtr8g089310.1

Common Name

MTR_8g089310

Organism

Medicago truncatula

Taxonomic ID

3880

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Trifolieae; Medicago

Family

LSD

Protein Properties

Length: 224aa MW: 23979.7 Da PI: 9.0388

Description

LSD family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Medtr8g089310.1	genome	Mt	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-LSD1	43.9	3.9e-14	54	78	1	25
zf-LSD1 1 CggCrtlLsYPrGApsVRCalCdtV 25 C+gCr++L YPrGA++V+CalC+t+ Medtr8g089310.1 54 CNGCRNTLLYPRGATNVCCALCNTI 78 ***********************97 PP
2	zf-LSD1	49.2	8.6e-16	93	117	1	25
zf-LSD1 1 CggCrtlLsYPrGApsVRCalCdtV 25 CggCrtlL+Y+rGA+sVRC++C+tV Medtr8g089310.1 93 CGGCRTLLMYTRGATSVRCSCCHTV 117 ************************9 PP
3	zf-LSD1	47	4.1e-15	131	154	1	24
zf-LSD1 1 CggCrtlLsYPrGApsVRCalCdt 24 Cg+Crt+L+YP+GApsV+Ca+C+ Medtr8g089310.1 131 CGNCRTTLMYPYGAPSVKCAVCHY 154 **********************96 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
TIGRFAMs	TIGR01053	1.5E-12	51	81	IPR005735	Zinc finger, LSD1-type
Pfam	PF06943	1.3E-11	54	78	IPR005735	Zinc finger, LSD1-type
TIGRFAMs	TIGR01053	8.8E-17	90	119	IPR005735	Zinc finger, LSD1-type
Pfam	PF06943	3.7E-13	93	117	IPR005735	Zinc finger, LSD1-type
TIGRFAMs	TIGR01053	7.2E-12	128	157	IPR005735	Zinc finger, LSD1-type
Pfam	PF06943	3.3E-14	131	155	IPR005735	Zinc finger, LSD1-type

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0000303	Biological Process	response to superoxide
GO:0001666	Biological Process	response to hypoxia
GO:0002240	Biological Process	response to molecule of oomycetes origin
GO:0009626	Biological Process	plant-type hypersensitive response
GO:0009862	Biological Process	systemic acquired resistance, salicylic acid mediated signaling pathway
GO:0010104	Biological Process	regulation of ethylene-activated signaling pathway
GO:0010310	Biological Process	regulation of hydrogen peroxide metabolic process
GO:0010602	Biological Process	regulation of 1-aminocyclopropane-1-carboxylate metabolic process
GO:0010618	Biological Process	aerenchyma formation
GO:0043069	Biological Process	negative regulation of programmed cell death

Sequence ? help Back to Top
Protein Sequence Length: 224 aa Download sequence Send to blast
MKKIDFVEGF SHFVKVIKGR CEENNIGSRR RRSHKEGRKE HGPGAAAMQS QLVCNGCRNT 60 LLYPRGATNV CCALCNTITA VPPPGMDMSQ LYCGGCRTLL MYTRGATSVR CSCCHTVNLA 120 PVSNQVAHVP CGNCRTTLMY PYGAPSVKCA VCHYITNINM SNGRLPIPGH RPHGTTDSGM 180 LPSTSTSMPQ SQSQTVVVEN PMSVDSSGKL VSNVVVGVTT DKK*

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
Mtr.5726	0.0	leaf\| root\| seed\| stem

Expression -- Description ? help Back to Top
Source	Description
Uniprot	TISSUE SPECIFICITY: Expressed in cotyledons, roots, rosette leaves, stems, inflorescences and flowers. {ECO:0000269\|PubMed:20456049}.

Functional Description ? help Back to Top
Source	Description
UniProt	Negative regulator of reactive oxygen-induced cell death, cold stress-induced cell death, pathogen-induced hypersensitive response (HR), basal disease resistance. May be involved in the induction of the copper/zinc superoxide dismutase CSD1 and CSD2 that detoxify accumulating superoxide before the reactive oxygen species (ROS) can trigger a cell death cascade. LSD1 and LOL1 have antagonistic effects on CSD1 and CSD2 accumulation to regulate oxidative stress-induced cell death. Antagonizes the function of BZIP10, a positive regulator of cell death, by interacting in the cytoplasm and preventing its nuclear localization. Controls lysigenous aerenchyma in hypocotyls under root hypoxia. Required for leaf acclimation in response to excess excitation energy. {ECO:0000269\|PubMed:10550898, ECO:0000269\|PubMed:11595797, ECO:0000269\|PubMed:11844114, ECO:0000269\|PubMed:12732715, ECO:0000269\|PubMed:15347794, ECO:0000269\|PubMed:16957775, ECO:0000269\|PubMed:18055613, ECO:0000269\|PubMed:18790826, ECO:0000269\|PubMed:20456049, ECO:0000269\|PubMed:21097903}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Medtr8g089310.1

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By methyl viologen. {ECO:0000269\|PubMed:20456049}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	BT053368	0.0	BT053368.1 Medicago truncatula clone MTYFP_FQ_FR_FS1G-L-7 unknown mRNA.
GenBank	BT146496	0.0	BT146496.1 Medicago truncatula clone JCVI-FLMt-10N12 unknown mRNA.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_024629307.1	1e-125	protein LSD1
Swissprot	P94077	3e-74	LSD1_ARATH; Protein LSD1
TrEMBL	G7L9L5	1e-163	G7L9L5_MEDTR; LSD1-type zinc finger protein
STRING	AET04489	1e-164	(Medicago truncatula)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF4027	33	61

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT4G20380.7	2e-73	LSD family protein

Link Out ? help Back to Top
Phytozome	Medtr8g089310.1
Entrez Gene	11427425

Publications ? help Back to Top
Spedaletti V, et al. Characterization of a lysine-specific histone demethylase from Arabidopsis thaliana. Biochemistry, 2008. 47(17): p. 4936-47 [PMID:18393445] Young ND, et al. The Medicago genome provides insight into the evolution of rhizobial symbioses. Nature, 2011. 480(7378): p. 520-4 [PMID:22089132] Szechyńska-Hebda M,Czarnocka W,Hebda M,Bernacki MJ,Karpiński S PAD4, LSD1 and EDS1 regulate drought tolerance, plant biomass production, and cell wall properties. Plant Cell Rep., 2016. 35(3): p. 527-39 [PMID:26754794] Czarnocka W, et al. The dual role of LESION SIMULATING DISEASE 1 as a condition-dependent scaffold protein and transcription regulator. Plant Cell Environ., 2017. 40(11): p. 2644-2662 [PMID:28555890] Bernacki MJ, et al. LSD1-, EDS1- and PAD4-dependent conditional correlation among salicylic acid, hydrogen peroxide, water use efficiency and seed yield in Arabidopsis thaliana. Physiol Plant, 2019. 165(2): p. 369-382 [PMID:30461017]