PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Medtr4g132430.2
Common NameMTR_4g132430
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Trifolieae; Medicago
Family WRKY
Protein Properties Length: 359aa    MW: 38323.8 Da    PI: 6.9273
Description WRKY family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Medtr4g132430.2genomeMtView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1WRKY97.21.1e-30127185259
                      --SS-EEEEEEE--TT-SS-EEEEEE-ST.T---EEEEEE-SSSTTEEEEEEES--SS- CS
             WRKY   2 dDgynWrKYGqKevkgsefprsYYrCtsa.gCpvkkkversaedpkvveitYegeHnhe 59 
                      +Dg++WrKYGqK+ kg+++pr+YYrCt+a gCpv+k+v+r+aed +++++tYeg+H h+
  Medtr4g132430.2 127 NDGCQWRKYGQKMAKGNPCPRAYYRCTMAlGCPVRKQVQRCAEDRSILITTYEGTHSHP 185
                      8*********************************************************7 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:2.20.25.802.5E-33111187IPR003657WRKY domain
SuperFamilySSF1182903.92E-28119187IPR003657WRKY domain
PROSITE profilePS5081128.966121187IPR003657WRKY domain
SMARTSM007741.2E-36126186IPR003657WRKY domain
PfamPF031064.5E-27127185IPR003657WRKY domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 359 aa     Download sequence    Send to blast
MLSDMNSSYT NLHNRFISLM QQQQNQTTEH DHIVNGKAVE KGDGVVARKF MNGPAAEVDD  60
QQEPEPCTPQ NNHKEPDPDA SELVQLLDRS QLPRLNPSNA ADQANAEATM RKARVSVRAR  120
SEAHMINDGC QWRKYGQKMA KGNPCPRAYY RCTMALGCPV RKQVQRCAED RSILITTYEG  180
THSHPLPPAA MPMASTTAAA ATVLLSGSMS SADGVMNPNL LARILPNCSS SMATLSASAP  240
FPTVTLDLTR DTTDNNGNSP SQFQLGQPQN FGSGQLPQVI AQALYNQSKF SGLQMSQDVG  300
GSSQLHPTQQ ASSLSAAITA DPNFTAALAA AISSIIGAAP PSNNNSNPNI INSATYNQ*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
2ayd_A1e-23113189176WRKY transcription factor 1
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Mtr.143240.0root
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Roots, leaves, shoots, flowers and siliques.
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor involved in the control of processes related to senescence and pathogen defense (PubMed:12000796). Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (PubMed:12000796). Activates the transcription of the SIRK gene and represses its own expression and that of the WRKY42 genes (PubMed:12000796). Modulates phosphate homeostasis and Pi translocation by regulating PHO1 expression (PubMed:25733771). {ECO:0000269|PubMed:12000796, ECO:0000269|PubMed:25733771}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapMedtr4g132430.2
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By salicylic acid, ethylene, jasmonic acid, pathogens, wounding and strongly during leaf senescence. {ECO:0000269|PubMed:11449049, ECO:0000269|PubMed:11722756}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAC1595360.0AC159536.21 Medicago truncatula chromosome 8 clone mth2-187n4, complete sequence.
GenBankAC2255370.0AC225537.2 Medicago truncatula clone mth2-66l14, complete sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_003610463.20.0probable WRKY transcription factor 31
SwissprotQ9C5191e-100WRKY6_ARATH; WRKY transcription factor 6
TrEMBLG7JJA30.0G7JJA3_MEDTR; WRKY1b transcription factor
TrEMBLG7JJA40.0G7JJA4_MEDTR; WRKY1b transcription factor
STRINGAES755000.0(Medicago truncatula)
STRINGAES926600.0(Medicago truncatula)
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G62300.14e-86WRKY family protein
Publications ? help Back to Top
  1. Zhou F, et al.
    High humidity suppresses ssi4-mediated cell death and disease resistance upstream of MAP kinase activation, H2O2 production and defense gene expression.
    Plant J., 2004. 39(6): p. 920-32
    [PMID:15341634]
  2. Young ND, et al.
    The Medicago genome provides insight into the evolution of rhizobial symbioses.
    Nature, 2011. 480(7378): p. 520-4
    [PMID:22089132]
  3. Ramírez V,López A,Mauch-Mani B,Gil MJ,Vera P
    An extracellular subtilase switch for immune priming in Arabidopsis.
    PLoS Pathog., 2013. 9(6): p. e1003445
    [PMID:23818851]
  4. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  5. Singh V,Roy S,Singh D,Nandi AK
    Arabidopsis flowering locus D influences systemic-acquired-resistance- induced expression and histone modifications of WRKY genes.
    J. Biosci., 2014. 39(1): p. 119-26
    [PMID:24499796]
  6. Ali MA,Wieczorek K,Kreil DP,Bohlmann H
    The beet cyst nematode Heterodera schachtii modulates the expression of WRKY transcription factors in syncytia to favour its development in Arabidopsis roots.
    PLoS ONE, 2014. 9(7): p. e102360
    [PMID:25033038]
  7. Chai J,Liu J,Zhou J,Xing D
    Mitogen-activated protein kinase 6 regulates NPR1 gene expression and activation during leaf senescence induced by salicylic acid.
    J. Exp. Bot., 2014. 65(22): p. 6513-28
    [PMID:25210078]
  8. Vermeirssen V,De Clercq I,Van Parys T,Van Breusegem F,Van de Peer Y
    Arabidopsis ensemble reverse-engineered gene regulatory network discloses interconnected transcription factors in oxidative stress.
    Plant Cell, 2014. 26(12): p. 4656-79
    [PMID:25549671]
  9. Xiao D, et al.
    SENESCENCE-SUPPRESSED PROTEIN PHOSPHATASE Directly Interacts with the Cytoplasmic Domain of SENESCENCE-ASSOCIATED RECEPTOR-LIKE KINASE and Negatively Regulates Leaf Senescence in Arabidopsis.
    Plant Physiol., 2015. 169(2): p. 1275-91
    [PMID:26304848]
  10. Bakshi M, et al.
    WRKY6 restricts Piriformospora indica-stimulated and phosphate-induced root development in Arabidopsis.
    BMC Plant Biol., 2015. 15: p. 305
    [PMID:26718529]
  11. Huang Y,Feng CZ,Ye Q,Wu WH,Chen YF
    Arabidopsis WRKY6 Transcription Factor Acts as a Positive Regulator of Abscisic Acid Signaling during Seed Germination and Early Seedling Development.
    PLoS Genet., 2016. 12(2): p. e1005833
    [PMID:26829043]
  12. Ramírez V,López A,Mauch-Mani B,Gil MJ,Vera P
    Correction: An Extracellular Subtilase Switch for Immune Priming in Arabidopsis.
    PLoS Pathog., 2016. 12(11): p. e1006003
    [PMID:27806116]
  13. Li H, et al.
    BZR1 Positively Regulates Freezing Tolerance via CBF-Dependent and CBF-Independent Pathways in Arabidopsis.
    Mol Plant, 2017. 10(4): p. 545-559
    [PMID:28089951]
  14. Stetter MG,Benz M,Ludewig U
    Increased root hair density by loss of WRKY6 in Arabidopsis thaliana.
    PeerJ, 2017. 5: p. e2891
    [PMID:28149680]
  15. Zhou X, et al.
    StMYB44 negatively regulates phosphate transport by suppressing expression of PHOSPHATE1 in potato.
    J. Exp. Bot., 2017. 68(5): p. 1265-1281
    [PMID:28338870]
  16. Bakshi M, et al.
    Piriformospora indica Reprograms Gene Expression in Arabidopsis Phosphate Metabolism Mutants But Does Not Compensate for Phosphate Limitation.
    Front Microbiol, 2017. 8: p. 1262
    [PMID:28747898]
  17. Zhang Y, et al.
    DELLA proteins negatively regulate dark-induced senescence and chlorophyll degradation in Arabidopsis through interaction with the transcription factor WRKY6.
    Plant Cell Rep., 2018. 37(7): p. 981-992
    [PMID:29574486]