PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Medtr3g081360.1
Common NameMTR_3g081360
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Trifolieae; Medicago
Family MYB_related
Protein Properties Length: 514aa    MW: 58327.3 Da    PI: 6.0708
Description MYB_related family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Medtr3g081360.1genomeMtView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Myb_DNA-binding38.92e-1293135346
                      SS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHH CS
  Myb_DNA-binding   3 rWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqk 46 
                       W++ E++ll++a+ ++G g+W+ +a+ +g +++  qc++++++
  Medtr3g081360.1  93 DWSAGEEKLLIEAIDMYGFGNWNGVAENVG-TKSKSQCIDHYNS 135
                      6*****************************.***********97 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PIRSFPIRSF0250249.4E-13221513IPR016827Transcriptional adaptor 2
SMARTSM002919.1E-83074IPR000433Zinc finger, ZZ-type
SuperFamilySSF578501.53E-143497No hitNo description
CDDcd023352.84E-243482No hitNo description
PfamPF005698.8E-83473IPR000433Zinc finger, ZZ-type
PROSITE profilePS501359.9243477IPR000433Zinc finger, ZZ-type
PROSITE patternPS0135703663IPR000433Zinc finger, ZZ-type
SuperFamilySSF466892.39E-1286140IPR009057Homeodomain-like
PROSITE profilePS5129319.61189141IPR017884SANT domain
SMARTSM007171.1E-1090139IPR001005SANT/Myb domain
PfamPF002491.1E-1293135IPR001005SANT/Myb domain
CDDcd001672.22E-1094136No hitNo description
Gene3DG3DSA:1.10.10.601.8E-894136IPR009057Homeodomain-like
PROSITE profilePS5093411.699427513IPR007526SWIRM domain
SuperFamilySSF466891.18E-17429512IPR009057Homeodomain-like
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006357Biological Processregulation of transcription from RNA polymerase II promoter
GO:0016573Biological Processhistone acetylation
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0005515Molecular Functionprotein binding
GO:0008270Molecular Functionzinc ion binding
Sequence ? help Back to Top
Protein Sequence    Length: 514 aa     Download sequence    Send to blast
MVFLSKRKKV ALNADDLEAS YAGMGITDGK VSLYHCNYCK KNISGKIHIK CAVCQDFDLC  60
IECFFVGAEL TPHKSNHPYR VMDSLSFPLT SPDWSAGEEK LLIEAIDMYG FGNWNGVAEN  120
VGTKSKSQCI DHYNSVYLNS PCFPLPDLSY SMGKNKEELL AMAKGHQLKK GLLLDDRNHN  180
FSEESKKAET TNQNMSRPTS ARDEALPSIT KKASNVNQNN DGVKVEESQA GWSAGEKKPK  240
LSGEYKPSME VLRGYNSNRG EFEIEYDNDA EQVLAEMEFK DTDTEAEREM KLQVLRGYGK  300
KLNERKRRKE FILERNLLCP DPFEKFLSPE ELQICEQYKV FMRFHSKEEH EELLQTAIRE  360
HRLAKRIKDL KEARIAGCVT SDEAYQFIEQ KRTKEAEQGN CKESGQIGTS GKTESFPSTK  420
DAPPAIQAIT KTLEEWDISD FEGAELLSES EIKLCNEIRM LPPIFLNITR IMQLEISKGR  480
VTKKSDAYPL FKFSPSKIDR IYDMLVEKGV VQA*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
6cw3_E2e-29341495120Transcriptional adapter 2
6cw3_G2e-29341495120Transcriptional adapter 2
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1304309RKRRKE
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in roots, leaves, stems, flowers and siliques, with the strongest activity in the meristematic zones. {ECO:0000269|PubMed:11266554, ECO:0000269|PubMed:12747832}.
Functional Description ? help Back to Top
Source Description
UniProtRequired for the function of some acidic activation domains, which activate transcription from a distant site. The exact mechanism of action is not yet known. ADA2 and GCN5 function to acetylate nucleosomes, opening up the promoter region (By similarity). {ECO:0000250}.
UniProtRequired for the function of some acidic activation domains, which activate transcription from a distant site. The exact mechanism of action is not yet known (By similarity). ADA2 stimulates the acetyltransferase activity of GCN5 on free histones or nucleosomes, probably by opening up the promoter region. Mediates auxin and cytokinin signals in the control of cell proliferation and might be involved in repression of a freezing tolerance pathway at warm temperature (PubMed:12615937, PubMed:12747832). Involved in the positive regulation of salt-induced gene expression by maintaining locus-specific acetylation of histones H4 and H3 (PubMed:21193996). {ECO:0000250, ECO:0000269|PubMed:12615937, ECO:0000269|PubMed:12747832, ECO:0000269|PubMed:21193996}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapMedtr3g081360.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankCU0248803e-75CU024880.19 M.truncatula DNA sequence from clone MTH2-7H19 on chromosome 3, complete sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_024634747.10.0transcriptional adapter ADA2b
SwissprotQ75LL61e-169TADA2_ORYSJ; Transcriptional adapter ADA2
SwissprotQ9ATB41e-170TAD2B_ARATH; Transcriptional adapter ADA2b
TrEMBLA0A072V1B90.0A0A072V1B9_MEDTR; Transcriptional adapter
STRINGAES717890.0(Medicago truncatula)
STRINGAES874460.0(Medicago truncatula)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF15371726
Publications ? help Back to Top
  1. Vlachonasios KE,Thomashow MF,Triezenberg SJ
    Disruption mutations of ADA2b and GCN5 transcriptional adaptor genes dramatically affect Arabidopsis growth, development, and gene expression.
    Plant Cell, 2003. 15(3): p. 626-38
    [PMID:12615937]
  2. Sieberer T,Hauser MT,Seifert GJ,Luschnig C
    PROPORZ1, a putative Arabidopsis transcriptional adaptor protein, mediates auxin and cytokinin signals in the control of cell proliferation.
    Curr. Biol., 2003. 13(10): p. 837-42
    [PMID:12747832]
  3. Kikuchi S, et al.
    Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice.
    Science, 2003. 301(5631): p. 376-9
    [PMID:12869764]
  4. Kerschen A,Napoli CA,Jorgensen RA,Müller AE
    Effectiveness of RNA interference in transgenic plants.
    FEBS Lett., 2004. 566(1-3): p. 223-8
    [PMID:15147899]
  5. Hark AT, et al.
    Two Arabidopsis orthologs of the transcriptional coactivator ADA2 have distinct biological functions.
    Biochim. Biophys. Acta, 2009. 1789(2): p. 117-24
    [PMID:18929690]
  6. Anzola JM, et al.
    Putative Arabidopsis transcriptional adaptor protein (PROPORZ1) is required to modulate histone acetylation in response to auxin.
    Proc. Natl. Acad. Sci. U.S.A., 2010. 107(22): p. 10308-13
    [PMID:20479223]
  7. Kaldis A,Tsementzi D,Tanriverdi O,Vlachonasios KE
    Arabidopsis thaliana transcriptional co-activators ADA2b and SGF29a are implicated in salt stress responses.
    Planta, 2011. 233(4): p. 749-62
    [PMID:21193996]
  8. Vlachonasios KE,Kaldis A,Nikoloudi A,Tsementzi D
    The role of transcriptional coactivator ADA2b in Arabidopsis abiotic stress responses.
    Plant Signal Behav, 2011. 6(10): p. 1475-8
    [PMID:21897124]
  9. Young ND, et al.
    The Medicago genome provides insight into the evolution of rhizobial symbioses.
    Nature, 2011. 480(7378): p. 520-4
    [PMID:22089132]
  10. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  11. Kazama D,Kurusu T,Mitsuda N,Ohme-Takagi M,Tada Y
    Involvement of elevated proline accumulation in enhanced osmotic stress tolerance in Arabidopsis conferred by chimeric repressor gene silencing technology.
    Plant Signal Behav, 2014. 9(3): p. e28211
    [PMID:24614501]
  12. Kim JY,Oh JE,Noh YS,Noh B
    Epigenetic control of juvenile-to-adult phase transition by the Arabidopsis SAGA-like complex.
    Plant J., 2015. 83(3): p. 537-45
    [PMID:26095998]
  13. Kazama D, et al.
    Identification of Chimeric Repressors that Confer Salt and Osmotic Stress Tolerance in Arabidopsis.
    Plants (Basel), 2013. 2(4): p. 769-85
    [PMID:27137403]
  14. Simon MK,Skinner DJ,Gallagher TL,Gasser CS
    Integument Development in Arabidopsis Depends on Interaction of YABBY Protein INNER NO OUTER with Coactivators and Corepressors.
    Genetics, 2017. 207(4): p. 1489-1500
    [PMID:28971961]
  15. Lai J, et al.
    The Transcriptional Coactivator ADA2b Recruits a Structural Maintenance Protein to Double-Strand Breaks during DNA Repair in Plants.
    Plant Physiol., 2018. 176(4): p. 2613-2622
    [PMID:29463775]
  16. Kotak J, et al.
    The histone acetyltransferase GCN5 and the transcriptional coactivator ADA2b affect leaf development and trichome morphogenesis in Arabidopsis.
    Planta, 2018. 248(3): p. 613-628
    [PMID:29846775]