PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Migut.O00242.1.p
Common NameLOC105975049, MIMGU_mgv1a002027mg
Organism
Mimulus guttatus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Phrymaceae; Erythranthe
Family HD-ZIP
Protein Properties Length: 726aa    MW: 80058.4 Da    PI: 6.6562
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Migut.O00242.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox61.51.3e-192782156
                      TT--SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS
          Homeobox  1 rrkRttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakek 56
                      +++ +++t++q+++Le++F+++++p++++r  L+++lgL  rq+k+WFqNrR+++k
  Migut.O00242.1.p 27 KKRYHRHTAHQIQRLESMFKECPHPDEKTRNLLSRELGLHPRQIKFWFQNRRTQMK 82
                      678899***********************************************998 PP
2START169.32.5e-532294552206
                       HHHHHHHHHHHHHHHC-T.T-EEEE....EXCCTTEEEEEEESSS.......SCEEEEEEEECCSCHHHHHHHHHCCCGGCT-TT-S....EE CS
             START   2 laeeaaqelvkkalaeep.gWvkss....esengdevlqkfeeskv......dsgealrasgvvdmvlallveellddkeqWdetla....ka 79 
                       +a +a++el+++++++e+ +W kss    e++n +++ ++f++ +        ++ea+r+sgvv+m++  lv  ++d + +W e ++    +a
  Migut.O00242.1.p 229 IAASAMDELIRLVQSNEEhLWIKSSsdgrEMLNLETYERTFPRPNDhlknpnVRIEASRDSGVVIMNSLALVDMFMDAN-KWVELFPtivsRA 320
                       67899*********976538*****9***************887669999999**************************.******99999** PP

                       EEEEEECTT......EEEEEEEEXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--.-TTSEE-EESSEEEEEEEECTCEEEEE CS
             START  80 etlevissg......galqlmvaelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppesssvvRaellpSgiliepksnghskvt 165
                        t+evissg      ++lqlm+ elq+ls lvp R f+f+R+++q + g w+iv vS d++ + ++ ss+ ++++lpSg+li++++ng+sk+t
  Migut.O00242.1.p 321 RTIEVISSGmlgsqsSTLQLMYEELQVLSALVPtRQFYFLRFRQQIEPGLWAIVNVSYDVPHQESQLSSSCKSQRLPSGCLIQDMPNGYSKIT 413
                       ***************************************************************9999************************** PP

                       EEE-EE--SSXX.HHHHHHHHHHHHHHHHHHHHHHTXXXXXX CS
             START 166 wvehvdlkgrlp.hwllrslvksglaegaktwvatlqrqcek 206
                       wveh +++++ p h l+r l++sgla+ga +w +tlqr ce+
  Migut.O00242.1.p 414 WVEHCEVEDKAPiHRLYRDLIQSGLAFGAERWISTLQRTCER 455
                       ****************************************97 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF466894.18E-201184IPR009057Homeodomain-like
Gene3DG3DSA:1.10.10.604.0E-221686IPR009057Homeodomain-like
PROSITE profilePS5007117.1842484IPR001356Homeobox domain
SMARTSM003896.2E-192588IPR001356Homeobox domain
CDDcd000863.69E-182685No hitNo description
PfamPF000463.6E-172782IPR001356Homeobox domain
PROSITE patternPS0002705982IPR017970Homeobox, conserved site
PROSITE profilePS5084845.407219458IPR002913START domain
SuperFamilySSF559618.93E-34220457No hitNo description
CDDcd088759.83E-113223454No hitNo description
SMARTSM002347.1E-43228455IPR002913START domain
PfamPF018521.1E-45229455IPR002913START domain
SuperFamilySSF559612.56E-20477653No hitNo description
SuperFamilySSF559612.56E-20680712No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009828Biological Processplant-type cell wall loosening
GO:0010091Biological Processtrichome branching
GO:0005634Cellular Componentnucleus
GO:0000976Molecular Functiontranscription regulatory region sequence-specific DNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0008289Molecular Functionlipid binding
Sequence ? help Back to Top
Protein Sequence    Length: 726 aa     Download sequence    Send to blast
MEFSSGGGGG GGGGSSGGDA SDPHRRKKRY HRHTAHQIQR LESMFKECPH PDEKTRNLLS  60
RELGLHPRQI KFWFQNRRTQ MKAQHERSDN CALRADNDKI RCENIAIREA LKNIICPSCG  120
GPPVTEDSYF DEQKLRIENA QLKEELDRVS SIAAKYIGRP ISQLPPVQPI HISSLDLSMA  180
SFGGHGINAG PTLDLDLDLL PGSSSSVIPN LPFPSLSISD LDKSLMSDIA ASAMDELIRL  240
VQSNEEHLWI KSSSDGREML NLETYERTFP RPNDHLKNPN VRIEASRDSG VVIMNSLALV  300
DMFMDANKWV ELFPTIVSRA RTIEVISSGM LGSQSSTLQL MYEELQVLSA LVPTRQFYFL  360
RFRQQIEPGL WAIVNVSYDV PHQESQLSSS CKSQRLPSGC LIQDMPNGYS KITWVEHCEV  420
EDKAPIHRLY RDLIQSGLAF GAERWISTLQ RTCERVAYLM VPGNSSRDPG GGVIPSPEGK  480
RSMTRLAQRM VSNFCSSINP SNGQQWTSVS GMNEFEVRAT LHRSTDPAQP NAVVLSAAAT  540
IWLPIPPQSV FNFFRDERTR PQWDVLSNQN PVQEVAHISN GSHPGNCISI LRAYNTSQNN  600
MLILQESCID SSGSIVVHCP VDLPSINVAM SGEDPTFLPL LPSGFTISPD GGPHQLHHGQ  660
YDVASTSSNS TTVDRSSSSG SLVTVVFQIL VSNSPSARMS PETVNTVNNL IGNTVHQIKA  720
ALNCN*
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1414SGGGGGGGGGS
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor which acts as positive regulator of drought stress tolerance. Can transactivate CIPK3, NCED3 and ERECTA (PubMed:18451323). Transactivates several cell-wall-loosening protein genes by directly binding to HD motifs in their promoters. These target genes play important roles in coordinating cell-wall extensibility with root development and growth (PubMed:24821957). Transactivates CYP74A/AOS, AOC3, OPR3 and 4CLL5/OPCL1 genes by directly binding to HD motifs in their promoters. These target genes are involved in jasmonate (JA) biosynthesis, and JA signaling affects root architecture by activating auxin signaling, which promotes lateral root formation (PubMed:25752924). Acts as negative regulator of trichome branching (PubMed:16778018, PubMed:24824485). Required for the establishment of giant cell identity on the abaxial side of sepals (PubMed:23095885). May regulate cell differentiation and proliferation during root and shoot meristem development (PubMed:25564655). {ECO:0000269|PubMed:16778018, ECO:0000269|PubMed:18451323, ECO:0000269|PubMed:23095885, ECO:0000269|PubMed:24821957, ECO:0000269|PubMed:24824485, ECO:0000269|PubMed:25564655, ECO:0000269|PubMed:25752924}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00232DAPTransfer from AT1G73360Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapMigut.O00242.1.p
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_012855673.10.0PREDICTED: homeobox-leucine zipper protein HDG11
SwissprotQ9FX310.0HDG11_ARATH; Homeobox-leucine zipper protein HDG11
TrEMBLA0A022Q4X30.0A0A022Q4X3_ERYGU; Uncharacterized protein
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA24902351
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G73360.10.0homeodomain GLABROUS 11
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Khosla A, et al.
    HD-Zip Proteins GL2 and HDG11 Have Redundant Functions in Arabidopsis Trichomes, and GL2 Activates a Positive Feedback Loop via MYB23.
    Plant Cell, 2014. 26(5): p. 2184-2200
    [PMID:24824485]
  3. Horstman A, et al.
    AIL and HDG proteins act antagonistically to control cell proliferation.
    Development, 2015. 142(3): p. 454-64
    [PMID:25564655]
  4. Cai XT,Xu P,Wang Y,Xiang CB
    Activated expression of AtEDT1/HDG11 promotes lateral root formation in Arabidopsis mutant edt1 by upregulating jasmonate biosynthesis.
    J Integr Plant Biol, 2015. 57(12): p. 1017-30
    [PMID:25752924]
  5. Yu LH, et al.
    Arabidopsis EDT1/HDG11 improves drought and salt tolerance in cotton and poplar and increases cotton yield in the field.
    Plant Biotechnol. J., 2016. 14(1): p. 72-84
    [PMID:25879154]
  6. Zhu Z, et al.
    Overexpression of AtEDT1/HDG11 in Chinese Kale (Brassica oleracea var. alboglabra) Enhances Drought and Osmotic Stress Tolerance.
    Front Plant Sci, 2016. 7: p. 1285
    [PMID:27625663]
  7. Liu Y, et al.
    Overexpression of AtEDT1 promotes root elongation and affects medicinal secondary metabolite biosynthesis in roots of transgenic Salvia miltiorrhiza.
    Protoplasma, 2017. 254(4): p. 1617-1625
    [PMID:27915455]
  8. Ueda M, et al.
    Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote.
    Genes Dev., 2017. 31(6): p. 617-627
    [PMID:28404632]
  9. Lung SC, et al.
    Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors.
    New Phytol., 2018. 218(1): p. 183-200
    [PMID:29288621]
  10. Zheng G, et al.
    Over-Expression of Arabidopsis EDT1 Gene Confers Drought Tolerance in Alfalfa (Medicago sativa L.).
    Front Plant Sci, 2017. 8: p. 2125
    [PMID:29326737]