PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Migut.I00063.1.p
Common NameLOC105952188, MIMGU_mgv1a008382mg
Organism
Mimulus guttatus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Phrymaceae; Erythranthe
Family E2F/DP
Protein Properties Length: 382aa    MW: 42533.3 Da    PI: 8.4257
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Migut.I00063.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP71.41e-222388171
           E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                      rk+ksL+ll+++fl+l+ ++  +++ l+++a++L    v  +rRRiYDi+NVLe+++++ +k+kn+++wkg
  Migut.I00063.1.p 23 RKQKSLGLLCSNFLSLYDREGIETIGLDDAASRL---GV--ERRRIYDIVNVLESVGILIRKAKNRYTWKG 88
                      79*****************999************...**..****************************98 PP
2E2F_TDP702.8e-22158245171
           E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse............dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                       rkeksL+lltq+f+kl+ +++ + ++l+++ak L+ +            +   k+RR+YDi+NVL++++ iek     ++k+++rw g
  Migut.I00063.1.p 158 RKEKSLGLLTQNFVKLFLCTDMDLISLEDAAKLLLGDgkhtsmttrisfNSPAKVRRLYDIANVLSSMKFIEKihhpeTRKPAFRWLG 245
                       79***********************************************88889********************************87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.3E-252189IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467853.11E-152386IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013727.6E-272388IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023195.1E-202488IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.101.1E-21154247IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.8E-27158245IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.4E-16159245IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.32E-11160246IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 382 aa     Download sequence    Send to blast
MALPSSVYSA AVESGSKDVP YCRKQKSLGL LCSNFLSLYD REGIETIGLD DAASRLGVER  60
RRIYDIVNVL ESVGILIRKA KNRYTWKGFG AIPEALEALK REGLRENGPF ADTSCSEKVS  120
DDEEDSMSSD INCLSQNDKS DTSSVLKSAM ASKSGENRKE KSLGLLTQNF VKLFLCTDMD  180
LISLEDAAKL LLGDGKHTSM TTRISFNSPA KVRRLYDIAN VLSSMKFIEK IHHPETRKPA  240
FRWLGLNGKP DNGIVDSKKR IFGTDLTNTA KRFKVDEDGL QILKPVNLMR VKNETENEDD  300
RTTTMGAKSY QFGPFAPANV PQVGVSNDDK GKQVVDWESL ASTYRPKYHN QALKDLFSHY  360
VEAWKSWYTE VAGKSPIQLM S*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A7e-36232374228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapMigut.I00063.1.p
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_012831164.10.0PREDICTED: E2F transcription factor-like E2FE isoform X1
SwissprotQ8LSZ41e-113E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A022RPY30.0A0A022RPY3_ERYGU; Uncharacterized protein
STRINGMigut.I00063.1.p0.0(Erythranthe guttata)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA25222457
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-112DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]