PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Migut.G00674.1.p

Organism

Mimulus guttatus

Taxonomic ID

4155

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Phrymaceae; Erythranthe

Family

bHLH

Protein Properties

Length: 220aa MW: 25198.9 Da PI: 4.804

Description

bHLH family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Migut.G00674.1.p	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	26.7	1e-08	192	220	1	29
CHHHHHHHHHHHHHHHHHHHHHHHCTSCC CS HLH 1 rrrahnerErrRRdriNsafeeLrellPk 29 +r++h ++Er+RR+++N+ + Lr+l+P+ Migut.G00674.1.p 192 QRMTHIAVERNRRKQMNEHLRVLRSLMPS 220 79*************************96 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF47459	1.26E-7	184	219	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
CDD	cd00083	5.49E-6	190	220	No hit	No description
Gene3D	G3DSA:4.10.280.10	3.3E-7	190	220	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profile	PS50888	11.49	191	220	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Pfam	PF00010	4.6E-6	192	220	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0046983	Molecular Function	protein dimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 220 aa Download sequence Send to blast
MEKEGNYSGN NFGGLDYNSM EVHQPTNQIV DYMLNNNPPL INQQPPPPPP NFPGGSNSFD 60 KLSFADVMQF ADFGPKLGLL NQSKATEELE NGLDPVYFLK FPVLNDDRHK LQDDDRNQEL 120 RDDVKVGDDD DGGENEIRFE ENIPINNNNN NSMRFLIGEN NIEKSPLIIT EGNKSKRKRP 180 RSTKTSEEVE SQRMTHIAVE RNRRKQMNEH LRVLRSLMPS

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	192	203	RMTHIAVERNRR

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269\|PubMed:17088607, ECO:0000269\|PubMed:17183265, ECO:0000269\|PubMed:17183267, ECO:0000269\|PubMed:24571519, ECO:0000269\|PubMed:24654956}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Migut.G00674.1.p

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269\|PubMed:22442411}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_012844517.1	1e-158	PREDICTED: transcription factor FAMA
Swissprot	Q56YJ8	1e-46	FAMA_ARATH; Transcription factor FAMA
TrEMBL	A0A022QUZ4	1e-138	A0A022QUZ4_ERYGU; Uncharacterized protein (Fragment)
STRING	Migut.G00674.1.p	1e-158	(Erythranthe guttata)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA4657	23	41

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G24140.1	2e-33	bHLH family protein

Link Out ? help Back to Top
Phytozome	Migut.G00674.1.p

Publications ? help Back to Top
Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature. Differentiation, 2010. 80(1): p. 1-8 [PMID:20219281] Matos JL, et al. Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module. Elife, 2015. [PMID:25303364] Chen L, et al. NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis. Development, 2016. 143(9): p. 1600-11 [PMID:26989174] Lee JH,Jung JH,Park CM Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis. Plant Cell, 2017. 29(11): p. 2817-2830 [PMID:29070509] Han X, et al. Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons. Plant Physiol., 2018. 176(4): p. 2871-2885 [PMID:29496884] Li X,Yang R,Chen H The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA. PLoS ONE, 2018. 13(3): p. e0193458 [PMID:29513733]