PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Migut.C00805.1.p
Common NameMIMGU_mgv1a026529mg
Organism
Mimulus guttatus
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Phrymaceae; Erythranthe
Family E2F/DP
Protein Properties Length: 414aa    MW: 45611.5 Da    PI: 7.9202
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Migut.C00805.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.12.6e-27151216171
           E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                       r+++sL+llt+kf+kl++++++g+++ln  a+ L   +v  ++RRiYDi+NVLe+++liek+ kn+irwkg
  Migut.C00805.1.p 151 RYDSSLGLLTKKFIKLIQEAKDGTLDLNRTADVL---QV--QKRRIYDITNVLEGIGLIEKTTKNHIRWKG 216
                       6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.5E-28150217IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013724.9E-35151216IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.5E-17151214IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.6E-25153216IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146609.98E-36227333No hitNo description
SuperFamilySSF1440741.57E-25230334No hitNo description
PfamPF164211.1E-23232331IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0000902Biological Processcell morphogenesis
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0042023Biological ProcessDNA endoreduplication
GO:0051782Biological Processnegative regulation of cell division
GO:0005667Cellular Componenttranscription factor complex
GO:0005730Cellular Componentnucleolus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0044212Molecular Functiontranscription regulatory region DNA binding
GO:0046982Molecular Functionprotein heterodimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 414 aa     Download sequence    Send to blast
MSTSGENLDL NLSLNLPLSR MQLENQAAPS LGRVRSNRFA CLPPPSNTAS SCGLASDKFA  60
ANYNNGVTAQ QSRTSVQTPP KNDPSIEGKI CGNTSIQVPK QEQTAYNGFP GPAYMMARSS  120
KKAKSVKHDK NAVKEAKLEP GDNLNLTGCC RYDSSLGLLT KKFIKLIQEA KDGTLDLNRT  180
ADVLQVQKRR IYDITNVLEG IGLIEKTTKN HIRWKGFGTV GSQKLDDGVS YLKAEVEHLS  240
AEECRLDNQI RDKQESLREL ISNQNCKKNL FLTKDDIMSL PSLRNQTVIA VEAPRASSIA  300
VPDPDEDIGF CQKQYSLMIR STTGPIAVYL LSKNEKKNKE ISVKRAKLMD PFTWTNSSRV  360
DDAELSLSPD TSTSSKGCGF QKIVPIDSGI DDDYWLRSEH EVSATDLWGT EEL*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A2e-25150218675PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInvolved in transcriptional repression. May act by repressing E2F-regulated genes in mature differentiated cells, but is not an antagonist of E2FA. Restricts cell division and is involved in the coordination between cell proliferation and endoreduplication during development. May play a role during the transition from skotomorphogenesis to photomorphogenesis. Regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(SKP2A) complex. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:16920782, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00190DAPTransfer from AT1G47870Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapMigut.C00805.1.p
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Down-regulated by light. {ECO:0000269|PubMed:12468727, ECO:0000269|PubMed:18424613}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_012835754.10.0PREDICTED: transcription factor E2FC
SwissprotQ9FV704e-84E2FC_ARATH; Transcription factor E2FC
TrEMBLA0A022RGC20.0A0A022RGC2_ERYGU; Uncharacterized protein
STRINGMigut.C00805.1.p0.0(Erythranthe guttata)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA126252022
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G47870.22e-86E2F/DP family protein
Publications ? help Back to Top
  1. Kobayashi K, et al.
    Transcriptional repression by MYB3R proteins regulates plant organ growth.
    EMBO J., 2015. 34(15): p. 1992-2007
    [PMID:26069325]
  2. Li B, et al.
    Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis.
    Plant Cell, 2018. 30(1): p. 178-195
    [PMID:29317470]
  3. Huntley R, et al.
    The maize retinoblastoma protein homologue ZmRb-1 is regulated during leaf development and displays conserved interactions with G1/S regulators and plant cyclin D (CycD) proteins.
    Plant Mol. Biol., 1998. 37(1): p. 155-69
    [PMID:9620273]