PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Home  TFext  BLAST  Prediction  Download  Help  About  Links  PlantRegMap
(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Manes.17G119400.1.p
Organism
Manihot esculenta
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae; Manihot
Family E2F/DP
Protein Properties Length: 373aa    MW: 42387.3 Da    PI: 8.5341
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Manes.17G119400.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP73.52.3e-231984171
              E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                         rkeksL++l+++fl+l+ +s+ + + l+++a++L    v  +rRRiYD++N+Le+++++++k+kn+++wkg
  Manes.17G119400.1.p 19 RKEKSLGVLCTNFLRLYDRSDVDSIGLDDAATRL---GV--ERRRIYDVVNILESIGVVARKQKNRYSWKG 84
                         79********************************...**..****************************98 PP
2E2F_TDP76.62.5e-24145224271
              E2F_TDP   2 keksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                          +eksL+lltq+f+kl+ +s+ +++tl+++a +L+ +      +++k+RR+YDi+NV++++nliek     ++k+++rw g
  Manes.17G119400.1.p 145 REKSLWLLTQNFVKLFLCSNVDMITLDNAAVSLLGDghnstAMRTKVRRLYDIANVFSSMNLIEKthhpdSRKPAFRWLG 224
                          79***************************************************************9999999******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.8E-251786IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467855.63E-161982IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013727.8E-271984IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.0E-202084IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.103.0E-22140224IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.5E-30144224IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.28E-12146225IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023198.1E-19146224IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0005737Cellular Componentcytoplasm
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 373 aa     Download sequence    Send to blast
MSSFVSRESD PSGRQFYCRK EKSLGVLCTN FLRLYDRSDV DSIGLDDAAT RLGVERRRIY  60
DVVNILESIG VVARKQKNRY SWKGFDAIPR ALEELKEEGF RENFCASASC NSAKVANENE  120
NEGSSSSKTD GQDNSSGASK SENKREKSLW LLTQNFVKLF LCSNVDMITL DNAAVSLLGD  180
GHNSTAMRTK VRRLYDIANV FSSMNLIEKT HHPDSRKPAF RWLGWRGNNE SVTSLDQPKK  240
RTFGTEITNY NTKRNKVDSS IDWNSNHQEE NVPVEIRCKD MENDCNKNKS DHHTKHSPKC  300
VEFGPFTPVG VQTAGESKNK IESRIEDLER LASTYYPRYN NRVLSDLFGH YVEAWKSWYV  360
EVAVKEKTQK GS*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A4e-34192164228Transcription factor E2F8
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
15576RRRIYDVVNILESIGVVARKQK
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Does not bind retinoblastoma-related proteins. Acts as a growth regulator but is not associated with changes in the expression of cell cycle marker genes or in nuclear ploidy levels. Has no effect on cell proliferation, but may repress cell wall biosynthesis genes during cell elongation in differentiated cells. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15308755}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapManes.17G119400.1.p
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_021598792.10.0E2F transcription factor-like E2FF isoform X1
SwissprotQ8RWL01e-126E2FF_ARATH; E2F transcription factor-like E2FF
TrEMBLA0A2C9U7F30.0A0A2C9U7F3_MANES; Uncharacterized protein
STRINGcassava4.1_008673m0.0(Manihot esculenta)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF36683366
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G01330.11e-126DP-E2F-like protein 3
Publications ? help Back to Top
  1. Dohmann EM, et al.
    The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability.
    Development, 2008. 135(11): p. 2013-22
    [PMID:18434413]