PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Manes.14G070800.1.p
Organism
Manihot esculenta
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae; Manihot
Family E2F/DP
Protein Properties Length: 442aa    MW: 49457.8 Da    PI: 8.283
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Manes.14G070800.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP702.8e-2265130171
              E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                          rk+ksL+ll+++fl+ + +   +i+ l+++a++L    v  +rRRiYD++NVLe+++++++k+kn+++wkg
  Manes.14G070800.1.p  65 RKQKSLGLLCSNFLSFYDRGGVEIIGLDDAASKL---GV--ERRRIYDVVNVLESVGVLARKAKNKYTWKG 130
                          79*****************999************...**..****************************98 PP
2E2F_TDP74.98.3e-24205285171
              E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                          rkeksL+llt++f+kl+ +s+++ ++l+e+ak L  +      +++k+RR+YDi+NVL++l+liek      +k++++w g
  Manes.14G070800.1.p 205 RKEKSLGLLTRNFVKLFVCSKADLISLDEAAKLLFGDahnlsIMRTKVRRLYDIANVLSSLELIEKthtaeARKPAFKWLG 285
                          79********************************999****999**********************9999999******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.104.8E-2562131IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467852.38E-1564128IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.4E-2665130IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.0E-1866130IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.103.2E-22202285IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.1E-30205285IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023196.9E-19206285IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467853.72E-12207286IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005667Cellular Componenttranscription factor complex
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 442 aa     Download sequence    Send to blast
MIMCHGAFSC YCFSENLDNF LNKEIPSTWK WISHFTCHIS SLSKIMPLSS GEAPESSCHH  60
APYSRKQKSL GLLCSNFLSF YDRGGVEIIG LDDAASKLGV ERRRIYDVVN VLESVGVLAR  120
KAKNKYTWKG FAAIPKALQE LKEDGLRENL SSFGKQQSSN CEKVSDYEND YEDECDSNPN  180
TGSQNDNSIP SGIVKSTAAP RYDNRKEKSL GLLTRNFVKL FVCSKADLIS LDEAAKLLFG  240
DAHNLSIMRT KVRRLYDIAN VLSSLELIEK THTAEARKPA FKWLGWRGKP ESGSGDALTE  300
SRKRKFGADV TNICFKRSQV DSSADGDRND NLKLPNQIKV ENVVTMADRS TSGQDSSKSY  360
HFGPFAPVTV AKVGGSDNKV TQTHDWDSLE STYRPRYHNE ALRELFAHYM EAWKSWCTEV  420
LARKQYKSSD ASPLCILMDS K*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A6e-40642793232Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapManes.14G070800.1.p
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_021634929.10.0E2F transcription factor-like E2FE isoform X1
SwissprotQ8LSZ41e-129E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A2C9ULF60.0A0A2C9ULF6_MANES; Uncharacterized protein
STRINGcassava4.1_009139m0.0(Manihot esculenta)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF36683366
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-131DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]