PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Manes.11G165300.2.p

Organism

Manihot esculenta

Taxonomic ID

3983

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae; Manihot

Family

E2F/DP

Protein Properties

Length: 435aa MW: 48620.6 Da PI: 5.0824

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Manes.11G165300.2.p	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	86.7	1.7e-27	143	208	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++l++++e+gi++ln++a++L +v ++RRiYDi+NVLe+++liekk kn+i+wkg Manes.11G165300.2.p 143 RYDSSLGLLTKKFINLIKHAEDGILDLNKAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 208 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	3.5E-29	141	210	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	2.72E-17	143	206	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	9.2E-35	143	208	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	1.4E-24	145	208	IPR003316	E2F/DP family, winged-helix DNA-binding domain
CDD	cd14660	1.90E-47	219	325	No hit	No description
SuperFamily	SSF144074	1.39E-33	220	325	No hit	No description
Pfam	PF16421	2.7E-33	224	323	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 435 aa Download sequence Send to blast
MSNSQPPNSS TRLPQQNVTQ NPLKRQLPFS SMKPPFSAPG DYHRFSSEPR RVADHDVEAI 60 VVKPPPFKRK SDAADHEAES SEWNTSTGFT EVVNSPLQTP VSGKGGKAPK TSRLSKSSKS 120 GPQNAASHLG SPGSNLTLTG PCRYDSSLGL LTKKFINLIK HAEDGILDLN KAADTLEVQK 180 RRIYDITNVL EGIGLIEKKL KNRIQWKGLD VSRPGEADEN VSSLQAEVEN LNIEEHRLDD 240 RIREVQERLR DLSEEETNQK WLFVTEEDIK SLPCFQNETL IAIKAPHGTT LEVPDPDEAV 300 DYPQRRYRIV LRSTMGPIDV YLVSQFEEKF EEIHGVEPPK SYPSTSGFNE NLATTMVPGE 360 SREKEIEMLG QDDHRMCSDL NTSQDFVSGI MKIVPTDVDS DADYWLLSDA GVSITDMWRT 420 ERILLKVLHS VCLI*

Sequence ? help Back to Top

Protein Sequence Length: 435 aa Download sequence Send to blast

MSNSQPPNSS TRLPQQNVTQ NPLKRQLPFS SMKPPFSAPG DYHRFSSEPR RVADHDVEAI  60
VVKPPPFKRK SDAADHEAES SEWNTSTGFT EVVNSPLQTP VSGKGGKAPK TSRLSKSSKS  120
GPQNAASHLG SPGSNLTLTG PCRYDSSLGL LTKKFINLIK HAEDGILDLN KAADTLEVQK  180
RRIYDITNVL EGIGLIEKKL KNRIQWKGLD VSRPGEADEN VSSLQAEVEN LNIEEHRLDD  240
RIREVQERLR DLSEEETNQK WLFVTEEDIK SLPCFQNETL IAIKAPHGTT LEVPDPDEAV  300
DYPQRRYRIV LRSTMGPIDV YLVSQFEEKF EEIHGVEPPK SYPSTSGFNE NLATTMVPGE  360
SREKEIEMLG QDDHRMCSDL NTSQDFVSGI MKIVPTDVDS DADYWLLSDA GVSITDMWRT  420
ERILLKVLHS VCLI*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	3e-26	141	209	5	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Manes.11G165300.2.p

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:18424613}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_021628243.1	0.0	transcription factor E2FB-like isoform X2
Swissprot	Q9FV71	1e-164	E2FB_ARATH; Transcription factor E2FB
TrEMBL	A0A2C9V1X4	0.0	A0A2C9V1X4_MANES; Uncharacterized protein
STRING	cassava4.1_007936m	0.0	(Manihot esculenta)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G22220.3	1e-167	E2F transcription factor 1

Link Out ? help Back to Top
Phytozome	Manes.11G165300.2.p

Publications ? help Back to Top
Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Wu M,Liu L,Hijazi H,Chan C A multi-layer inference approach to reconstruct condition-specific genes and their regulation. Bioinformatics, 2013. 29(12): p. 1541-52 [PMID:23610368] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325]