PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Manes.08G031600.1.p
Organism
Manihot esculenta
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae; Manihot
Family E2F/DP
Protein Properties Length: 465aa    MW: 51234.1 Da    PI: 4.8454
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Manes.08G031600.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP86.32.3e-27149214171
              E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 
                          r+++sL+llt+kf++l++++e+gi++ln++a++L   +v  ++RRiYDi+NVLe+++liekk kn+irwkg
  Manes.08G031600.1.p 149 RYDSSLGLLTKKFVNLIKRAEDGILDLNKAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIRWKG 214
                          6899******************************...99..****************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.1E-29146216IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013724.9E-34149214IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.18E-16149212IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023191.3E-24151214IPR003316E2F/DP family, winged-helix DNA-binding domain
CDDcd146601.30E-41228331No hitNo description
SuperFamilySSF1440749.94E-33228331No hitNo description
PfamPF164219.3E-34230329IPR032198E2F transcription factor, CC-MB domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051446Biological Processpositive regulation of meiotic cell cycle
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 465 aa     Download sequence    Send to blast
MSGSSRASTR PPTAAAATPP PGPILPPLRR HLAFATMKPP FVPPDDYHQF TSPTTNRAAT  60
DREAEGIVVR SPMLKRKNGS DENGGDSSEW ASNSGFGDVS NSSFQTPVSA KGGRTYNRSK  120
ASKGTRSGPH TPASNIDSPS PLTPAGSCRY DSSLGLLTKK FVNLIKRAED GILDLNKAAE  180
TLEVQKRRIY DITNVLEGIG LIEKKLKNRI RWKGVDASRP GEAEGDASLL QVEIEKLSME  240
EHRLDDQIRE MQERLRELSE EENNQKWLFV TEEDIKSIPC FQNETLIAIK APHGTTLEVP  300
DPAEAVEYPQ RRYRIILRST MGPIDVYLVS QFEENFEEMN GEPSTSIPHV SSSGSNEIPG  360
KVMINEQRIQ KRDEPQVQQV NSFVDLDASQ ELTGGMLKIV PSDVDNDADY WLLSDADVSI  420
TDIWRTDSNV EWSDFEIPDV HTPRAQTPPS GIGEVPSGGN SARR*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1cf7_A7e-25144215274PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269|PubMed:11669580, ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11862494, ECO:0000269|PubMed:11889041, ECO:0000269|PubMed:11891240, ECO:0000269|PubMed:12913157, ECO:0000269|PubMed:15377755, ECO:0000269|PubMed:16514015, ECO:0000269|PubMed:19662336}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00293DAPTransfer from AT2G36010Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapManes.08G031600.1.p
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_021619810.10.0transcription factor E2FA
SwissprotQ9FNY01e-171E2FA_ARATH; Transcription factor E2FA
TrEMBLA0A2C9VD100.0A0A2C9VD10_MANES; Uncharacterized protein
STRINGcassava4.1_030363m0.0(Manihot esculenta)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF19473490
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT2G36010.11e-164E2F transcription factor 3
Publications ? help Back to Top
  1. Magyar Z, et al.
    Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes.
    EMBO J., 2012. 31(6): p. 1480-93
    [PMID:22307083]