PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Manes.06G100000.1.p
Organism
Manihot esculenta
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae; Manihot
Family E2F/DP
Protein Properties Length: 386aa    MW: 42771.1 Da    PI: 8.1876
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Manes.06G100000.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP74.61e-232085171
              E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                         rk+ksL+ll+++fl+l+ k   +++ l+++a++L    v  +rRRiYDi+NVLe+++++++k+kn+++wkg
  Manes.06G100000.1.p 20 RKQKSLGLLCTNFLSLYDKDGIEVIGLDDAASKL---GV--ERRRIYDIVNVLESVGVLARKAKNKYTWKG 85
                         79*****************999************...**..****************************98 PP
2E2F_TDP789e-25160240171
              E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                          rkeksL+lltq+f+kl+ +s+++ ++l+e+ak L+ +      +++k+RR+YDi+NVL++l+liek      +k+++rw g
  Manes.06G100000.1.p 160 RKEKSLGLLTQNFVKLFVCSKADLISLDEAAKLLLGDahnlsIMRTKVRRLYDIANVLSSLKLIEKthtaeARKPAFRWLG 240
                          79****************************************99**********************9999999******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.103.2E-261786IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467857.32E-161983IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.1E-272085IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023194.7E-202185IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.103.1E-23158242IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.0E-31160240IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.4E-19161240IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467856.33E-13162241IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 386 aa     Download sequence    Send to blast
MPLSSSEAPE SSCRHLTYSR KQKSLGLLCT NFLSLYDKDG IEVIGLDDAA SKLGVERRRI  60
YDIVNVLESV GVLARKAKNK YTWKGFGAIP KALQELKEEG LRENLSSFDK QQSSNFEKLS  120
DDDNDDEDDC DSNPNTGSQN DNAIPSGIVK STAASRFDNR KEKSLGLLTQ NFVKLFVCSK  180
ADLISLDEAA KLLLGDAHNL SIMRTKVRRL YDIANVLSSL KLIEKTHTAE ARKPAFRWLG  240
LKGKPESGPV DALAEGRKRT FGADVTNICF KRNKLDSLAD GEKSNNLKLP NQIKFENVVT  300
IADASTSGQD FSKSYQFGPF APATVAKAGG DDNKSTQSHD WESLASTYRP QYHNQALREL  360
FAHYMEAWQS WYTEVAGKKP IQQIS*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A4e-41192343232Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapManes.06G100000.1.p
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_021615368.10.0E2F transcription factor-like E2FE
RefseqXP_021615369.10.0E2F transcription factor-like E2FE
SwissprotQ8LSZ41e-133E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A2C9VPM80.0A0A2C9VPM8_MANES; Uncharacterized protein
STRINGcassava4.1_009539m0.0(Manihot esculenta)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF36683366
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-135DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]