PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Manes.02G224400.1.p
Organism
Manihot esculenta
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae; Manihot
Family HD-ZIP
Protein Properties Length: 715aa    MW: 78689.5 Da    PI: 6.8945
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Manes.02G224400.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox60.52.7e-193489156
                         TT--SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS
             Homeobox  1 rrkRttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakek 56
                         +++ +++t++q++ Le++F+++++p++++r +L+++l+L  rq+k+WFqNrR+++k
  Manes.02G224400.1.p 34 KKRYHRHTANQIQKLEAMFKECPHPDEKQRLQLSRELSLAPRQIKFWFQNRRTQMK 89
                         678899***********************************************998 PP
2START182.81.9e-572304512206
                          HHHHHHHHHHHHHHHC-TT-EEEE....EXCCTTEEEEEEESSS.......SCEEEEEEEECCSCHHHHHHHHHCCCGGCT-TT-S.... CS
                START   2 laeeaaqelvkkalaeepgWvkss....esengdevlqkfeeskv......dsgealrasgvvdmvlallveellddkeqWdetla.... 77 
                          +a +a++el+++ + +ep+W ks+    + +n d++ + f++  +       ++ea+r+sg+v+m++  lv   +d + +W e ++    
  Manes.02G224400.1.p 230 IAASAMDELLRLLQTDEPLWIKSPtdgrDVLNLDTYQTLFPRVTSrmknpnIRIEASRDSGFVIMNSLALVDMAMDAN-KWVELFPtivs 318
                          67899*******************9999889999998888887779999999**************************.******99999 PP

                          EEEEEEEECTT......EEEEEEEEXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--.-TTSEE-EESSEEEEEEEECTC CS
                START  78 kaetlevissg......galqlmvaelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppesssvvRaellpSgiliepksng 160
                           a+tlevissg      g lqlm+ elq+lspl p R+f+++R+++q ++g w+iv vS d +++ ++     R+++lpSg++i++++ng
  Manes.02G224400.1.p 319 TAKTLEVISSGmmashsGSLQLMYEELQVLSPLIPtREFYILRHCQQIEQGLWAIVNVSYDIPEFASQ----CRSHRLPSGCMIQDMPNG 404
                          *****************************************************************986....****************** PP

                          EEEEEEEE-EE--SSXX.HHHHHHHHHHHHHHHHHHHHHHTXXXXXX CS
                START 161 hskvtwvehvdlkgrlp.hwllrslvksglaegaktwvatlqrqcek 206
                          +skvtwvehv++++++p h l+r l++sg+a+ga +w+atlqr+ce+
  Manes.02G224400.1.p 405 YSKVTWVEHVEVEDKTPtHRLYRDLIHSGMAFGAERWLATLQRLCER 451
                          *********************************************97 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF466898.77E-201891IPR009057Homeodomain-like
Gene3DG3DSA:1.10.10.601.6E-222293IPR009057Homeodomain-like
PROSITE profilePS5007117.6863191IPR001356Homeobox domain
SMARTSM003894.2E-183295IPR001356Homeobox domain
CDDcd000864.71E-183392No hitNo description
PfamPF000467.9E-173489IPR001356Homeobox domain
PROSITE patternPS0002706689IPR017970Homeobox, conserved site
PROSITE profilePS5084854.277220454IPR002913START domain
SuperFamilySSF559611.04E-38221452No hitNo description
CDDcd088759.10E-115224450No hitNo description
SMARTSM002341.5E-52229451IPR002913START domain
PfamPF018526.7E-50230451IPR002913START domain
Gene3DG3DSA:3.30.530.208.3E-9289437IPR023393START-like domain
SuperFamilySSF559611.34E-23472706No hitNo description
Gene3DG3DSA:3.30.530.201.1E-4480558IPR023393START-like domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009828Biological Processplant-type cell wall loosening
GO:0010091Biological Processtrichome branching
GO:0005634Cellular Componentnucleus
GO:0000976Molecular Functiontranscription regulatory region sequence-specific DNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0008289Molecular Functionlipid binding
Sequence ? help Back to Top
Protein Sequence    Length: 715 aa     Download sequence    Send to blast
MACVPLYQKR ETLALGGSGG GSGDHDPSDP HRRKKRYHRH TANQIQKLEA MFKECPHPDE  60
KQRLQLSREL SLAPRQIKFW FQNRRTQMKA QHERADNCAL RAENDKIRCE NIAIREALRN  120
VICPSCGGPP VTEDSYFDEH KLRMENAQLK EELDRVSSIA AKYIGRPISH LPPVQPIHVS  180
SLDLSMGSFG GQGNGGPSLD LDLDLIPSTS NLPFHPLGIS DMDKSLMTDI AASAMDELLR  240
LLQTDEPLWI KSPTDGRDVL NLDTYQTLFP RVTSRMKNPN IRIEASRDSG FVIMNSLALV  300
DMAMDANKWV ELFPTIVSTA KTLEVISSGM MASHSGSLQL MYEELQVLSP LIPTREFYIL  360
RHCQQIEQGL WAIVNVSYDI PEFASQCRSH RLPSGCMIQD MPNGYSKVTW VEHVEVEDKT  420
PTHRLYRDLI HSGMAFGAER WLATLQRLCE RFACLMVSGN STRDLGGVIP SPEGKRSMMK  480
LAQRMVQSFC ASISTSNSHR WTTVSGMNEV GVRVHKSTDP GQPNGVVLNA ATTFRLPVSP  540
QNVFNFFKDE RTRSQWDVLS SGNAVQEVAH IANGSHPGNC ISVLRAFNSG QNNMLILQES  600
CIDASGSLVV YCPVDLPAVN IAMSGEDPSY IPLLPSGFTI SPDGGADHGD GASSSSNTHG  660
SMSRSSGSLI TVSFQILVSS LPSAKLNLES VTTVNNLIST TVQQIKAAMN CPSS*
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor which acts as positive regulator of drought stress tolerance. Can transactivate CIPK3, NCED3 and ERECTA (PubMed:18451323). Transactivates several cell-wall-loosening protein genes by directly binding to HD motifs in their promoters. These target genes play important roles in coordinating cell-wall extensibility with root development and growth (PubMed:24821957). Transactivates CYP74A/AOS, AOC3, OPR3 and 4CLL5/OPCL1 genes by directly binding to HD motifs in their promoters. These target genes are involved in jasmonate (JA) biosynthesis, and JA signaling affects root architecture by activating auxin signaling, which promotes lateral root formation (PubMed:25752924). Acts as negative regulator of trichome branching (PubMed:16778018, PubMed:24824485). Required for the establishment of giant cell identity on the abaxial side of sepals (PubMed:23095885). May regulate cell differentiation and proliferation during root and shoot meristem development (PubMed:25564655). {ECO:0000269|PubMed:16778018, ECO:0000269|PubMed:18451323, ECO:0000269|PubMed:23095885, ECO:0000269|PubMed:24821957, ECO:0000269|PubMed:24824485, ECO:0000269|PubMed:25564655, ECO:0000269|PubMed:25752924}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00232DAPTransfer from AT1G73360Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapManes.02G224400.1.p
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_021602738.10.0homeobox-leucine zipper protein HDG11-like
SwissprotQ9FX310.0HDG11_ARATH; Homeobox-leucine zipper protein HDG11
TrEMBLA0A2C9WGD20.0A0A2C9WGD2_MANES; Uncharacterized protein
STRINGXP_002527933.10.0(Ricinus communis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF10263398
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G73360.10.0homeodomain GLABROUS 11
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Khosla A, et al.
    HD-Zip Proteins GL2 and HDG11 Have Redundant Functions in Arabidopsis Trichomes, and GL2 Activates a Positive Feedback Loop via MYB23.
    Plant Cell, 2014. 26(5): p. 2184-2200
    [PMID:24824485]
  3. Horstman A, et al.
    AIL and HDG proteins act antagonistically to control cell proliferation.
    Development, 2015. 142(3): p. 454-64
    [PMID:25564655]
  4. Cai XT,Xu P,Wang Y,Xiang CB
    Activated expression of AtEDT1/HDG11 promotes lateral root formation in Arabidopsis mutant edt1 by upregulating jasmonate biosynthesis.
    J Integr Plant Biol, 2015. 57(12): p. 1017-30
    [PMID:25752924]
  5. Yu LH, et al.
    Arabidopsis EDT1/HDG11 improves drought and salt tolerance in cotton and poplar and increases cotton yield in the field.
    Plant Biotechnol. J., 2016. 14(1): p. 72-84
    [PMID:25879154]
  6. Zhu Z, et al.
    Overexpression of AtEDT1/HDG11 in Chinese Kale (Brassica oleracea var. alboglabra) Enhances Drought and Osmotic Stress Tolerance.
    Front Plant Sci, 2016. 7: p. 1285
    [PMID:27625663]
  7. Liu Y, et al.
    Overexpression of AtEDT1 promotes root elongation and affects medicinal secondary metabolite biosynthesis in roots of transgenic Salvia miltiorrhiza.
    Protoplasma, 2017. 254(4): p. 1617-1625
    [PMID:27915455]
  8. Ueda M, et al.
    Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote.
    Genes Dev., 2017. 31(6): p. 617-627
    [PMID:28404632]
  9. Lung SC, et al.
    Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors.
    New Phytol., 2018. 218(1): p. 183-200
    [PMID:29288621]
  10. Zheng G, et al.
    Over-Expression of Arabidopsis EDT1 Gene Confers Drought Tolerance in Alfalfa (Medicago sativa L.).
    Front Plant Sci, 2017. 8: p. 2125
    [PMID:29326737]