PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

MDP0000808163

Common Name

GRF3

Organism

Malus domestica

Taxonomic ID

3750

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus

Family

GRF

Protein Properties

Length: 395aa MW: 42772.5 Da PI: 7.7918

Description

GRF family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
MDP0000808163	genome	GDR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	WRC	78.9	4.8e-25	146	189	1	44
WRC 1 daepgrCrRtDGKkWRCsrrvlegkklCErHlhrgrsrsrkske 44 d+ep rCrRtDGKkWRCsr+v++g+k+CErH+hrgr+rsrk++e MDP0000808163 146 DPEPTRCRRTDGKKWRCSRDVVAGQKYCERHVHRGRNRSRKPVE 189 79***************************************997 PP
2	QLQ	53.5	7.1e-19	75	111	1	37
QLQ 1 saFTaaQlqlLksQilAyKyLaanqPvPpeLlqaiqk 37 s+F+ +Q+q+L+ Q+l+++y++a++ vPpeLlq+i+k MDP0000808163 75 SYFSLSQWQELELQALIFRYMVAGAAVPPELLQPIRK 111 78*********************************86 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SMART	SM00951	5.4E-10	75	111	IPR014978	Glutamine-Leucine-Glutamine, QLQ
PROSITE profile	PS51666	21.338	76	111	IPR014978	Glutamine-Leucine-Glutamine, QLQ
Pfam	PF08880	1.1E-13	76	110	IPR014978	Glutamine-Leucine-Glutamine, QLQ
PROSITE profile	PS51667	25.087	146	190	IPR014977	WRC domain
Pfam	PF08879	1.1E-21	147	189	IPR014977	WRC domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0005524	Molecular Function	ATP binding

Sequence ? help Back to Top
Protein Sequence Length: 395 aa Download sequence Send to blast
MDFHLEQWRT QQHESEEQHS AKIPKLDLDP HQNSELPSAG YALPLFVPEP NTKILSAAFS 60 ESSPATSRFP KEMGSYFSLS QWQELELQAL IFRYMVAGAA VPPELLQPIR KSLHSAPYFL 120 HHPLQQFPHL QPALLQSGYW GRAAMDPEPT RCRRTDGKKW RCSRDVVAGQ KYCERHVHRG 180 RNRSRKPVEV ATTTTAATTT AGGGGSGTSL NNATTVTNTS ATGTHFALSG SSSSPSIDLL 240 HLNQSSSEAK PENMSLFGPC SEVFASAKSD SHVLRPFFDD WPGKLQELDN ARSNASSMNS 300 ATSLSISIRG TTSSDVSLKL STGNGVEPGH QDSHAERGQP HLNWPAGWAT NQMASMGGPL 360 AEALRSSSNS NSSPTSVLHR LPRASASEAS FIST*

Sequence ? help Back to Top

Protein Sequence Length: 395 aa Download sequence Send to blast

MDFHLEQWRT QQHESEEQHS AKIPKLDLDP HQNSELPSAG YALPLFVPEP NTKILSAAFS  60
ESSPATSRFP KEMGSYFSLS QWQELELQAL IFRYMVAGAA VPPELLQPIR KSLHSAPYFL  120
HHPLQQFPHL QPALLQSGYW GRAAMDPEPT RCRRTDGKKW RCSRDVVAGQ KYCERHVHRG  180
RNRSRKPVEV ATTTTAATTT AGGGGSGTSL NNATTVTNTS ATGTHFALSG SSSSPSIDLL  240
HLNQSSSEAK PENMSLFGPC SEVFASAKSD SHVLRPFFDD WPGKLQELDN ARSNASSMNS  300
ATSLSISIRG TTSSDVSLKL STGNGVEPGH QDSHAERGQP HLNWPAGWAT NQMASMGGPL  360
AEALRSSSNS NSSPTSVLHR LPRASASEAS FIST*

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
Mdo.11207	0.0	bud\| fruit\| leaf

Expression -- Description ? help Back to Top
Source	Description
Uniprot	DEVELOPMENTAL STAGE: Expressed during the early stages of leaf development and expression decreases with the maturation of the leaf. {ECO:0000269\|PubMed:20023165}.
Uniprot	TISSUE SPECIFICITY: Strongly expressed in actively growing and developing tissues, such as roots, upper stems, and shoot tips containing the shoot apical meristem (SAM) and flower buds. Also expressed in mature flowers, but weakly expressed in mature stems and leaves. {ECO:0000269\|PubMed:12974814}.

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that plays a role in the regulation of cell expansion in leaf and cotyledons tissues. Component of a network formed by miR396, the GRFs and their interacting factors (GIFs) acting in the regulation of meristem function, at least partially through the control of cell proliferation. {ECO:0000250}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: microRNA 396 (miR396a or miR396b) negatively regulates growth-regulating factors (GRF1-4 and GRF7-9). {ECO:0000269\|PubMed:15200956, ECO:0000269\|PubMed:19453503, ECO:0000269\|PubMed:20023165}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_028946164.1	0.0	growth-regulating factor 3-like isoform X1
Swissprot	Q8L8A7	8e-86	GRF4_ARATH; Growth-regulating factor 4
TrEMBL	D9ZIZ9	0.0	D9ZIZ9_MALDO; GRF domain class transcription factor
STRING	XP_009365359.1	0.0	(Pyrus x bretschneideri)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF7895	32	42

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G52910.1	1e-76	growth-regulating factor 4

Link Out ? help Back to Top
Phytozome	MDP0000808163

Publications ? help Back to Top
Kuijt SJ, et al. Interaction between the GROWTH-REGULATING FACTOR and KNOTTED1-LIKE HOMEOBOX families of transcription factors. Plant Physiol., 2014. 164(4): p. 1952-66 [PMID:24532604] Cao Y,Han Y,Jin Q,Lin Y,Cai Y Comparative Genomic Analysis of the GRF Genes in Chinese Pear (Pyrus bretschneideri Rehd), Poplar (Populous), Grape (Vitis vinifera), Arabidopsis and Rice (Oryza sativa). Front Plant Sci, 2016. 7: p. 1750 [PMID:27933074]