PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000765473
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family HD-ZIP
Protein Properties Length: 710aa    MW: 78378.2 Da    PI: 6.8832
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000765473genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox63.33.6e-202681156
                   TT--SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS
       Homeobox  1 rrkRttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakek 56
                   +++ +++t++q+++Le +++++++p++++r +L+++lgL  rq+k+WFqNrR+++k
  MDP0000765473 26 KKRYHRHTAHQIQRLEGMYKECPHPDEKQRMQLSRELGLAPRQIKFWFQNRRTQMK 81
                   678899***********************************************998 PP
2START185.92.1e-582254482206
                    HHHHHHHHHHHHHHHC-TT-EEEE....EXCCTTEEEEEEESSS.......SCEEEEEEEECCSCHHHHHHHHHCCCGG...CT-TT-SEEEEEEE CS
          START   2 laeeaaqelvkkalaeepgWvkss....esengdevlqkfeeskv......dsgealrasgvvdmvlallveellddke...qWdetlakaetlev 84 
                    +a  a+ el+++ + ++p+W+kss    + +n + + ++f+++ +       ++ea+r+sgvv+m    lv  ++d ++    + + +  a t+ev
  MDP0000765473 225 IAANAMXELLRLLQTNDPLWMKSStdgrDVLNLESYERIFPRATShsknpyVRIEASRDSGVVIMSGLALVDMFIDLNKfaeLFPTIVSMARTIEV 320
                    57889********************999999999999999998779999*99**************************55555555555******* PP

                    ECTT.....EEEEEEEEXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--.-TTSEE-EESSEEEEEEEECTCEEEEEEEE-EE--S CS
          START  85 issg.....galqlmvaelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppesssvvRaellpSgiliepksnghskvtwvehvdlkg 174
                    is+g     g lqlm++elq+lsplvp R+f+f+Ry++q ++g w+ivdvS d +q+++  ++  R+++lpSg+li++++ng+skvtwvehv+ ++
  MDP0000765473 321 ISPGmlgghGSLQLMYNELQVLSPLVPtREFYFLRYCQQIEQGLWAIVDVSYDFPQDNQ-FANQCRSHRLPSGCLIQDMPNGYSKVTWVEHVEIED 415
                    **********************************************************9.8*********************************** PP

                    SXX.HHHHHHHHHHHHHHHHHHHHHHTXXXXXX CS
          START 175 rlp.hwllrslvksglaegaktwvatlqrqcek 206
                    ++p h ++r l++sgla+ga++w+a+lqr ce+
  MDP0000765473 416 KVPtHRIYRDLIHSGLAFGAQRWLAALQRMCER 448
                    *******************************97 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF466891.71E-201184IPR009057Homeodomain-like
Gene3DG3DSA:1.10.10.601.9E-221285IPR009057Homeodomain-like
PROSITE profilePS5007117.3462383IPR001356Homeobox domain
SMARTSM003891.7E-182487IPR001356Homeobox domain
CDDcd000864.56E-182584No hitNo description
PfamPF000469.2E-182681IPR001356Homeobox domain
PROSITE patternPS0002705881IPR017970Homeobox, conserved site
PROSITE profilePS5084850.503215451IPR002913START domain
SuperFamilySSF559612.25E-39216449No hitNo description
CDDcd088751.51E-113219447No hitNo description
SMARTSM002341.7E-47224448IPR002913START domain
PfamPF018521.7E-49225448IPR002913START domain
Gene3DG3DSA:3.30.530.205.3E-9279447IPR023393START-like domain
SuperFamilySSF559611.4E-23470701No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0008289Molecular Functionlipid binding
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 710 aa     Download sequence    Send to blast
MEYGSGRGGS SGGDHHDDSS GSQRRKKRYH RHTAHQIQRL EGMYKECPHP DEKQRMQLSR  60
ELGLAPRQIK FWFQNRRTQM KAQNERSDNC ALRAENDKIR CENIAIREAL KNVIXPSCGV  120
PPLNEDSYFD EQKLRMENAQ LKQELDRVSS IAAKYIGRPI SQLPPVQPIH ISSLDLSMAS  180
FGGHGLAGPS LDLDLLPGSA LSTMPNLPYQ PPGFSDMDKS LMTDIAANAM XELLRLLQTN  240
DPLWMKSSTD GRDVLNLESY ERIFPRATSH SKNPYVRIEA SRDSGVVIMS GLALVDMFID  300
LNKFAELFPT IVSMARTIEV ISPGMLGGHG SLQLMYNELQ VLSPLVPTRE FYFLRYCQQI  360
EQGLWAIVDV SYDFPQDNQF ANQCRSHRLP SGCLIQDMPN GYSKVTWVEH VEIEDKVPTH  420
RIYRDLIHSG LAFGAQRWLA ALQRMCERFA CLMVSGTYTR DLEGVIPSPQ GKRSMMKLAQ  480
RMVNNFCANI SASNGHRWTT LSGMDEIGVR VAIHKSTDPG QPNGVVLSAG TTIWLPLSPQ  540
NVFNFFKDER TRPQWDVLSN GNAVQDVAHI ANGSHPGNCI SVLRAFNTNQ NNMLILQESC  600
IDSSGSLVVY SPIDLPAINI AMSGEDSSXI PLLPSGFTIS PDGRADQGDG ASSSSCNANG  660
SGSLVTVALQ ILVSSLPSAK LNLESVNTVN NLIGTTVQQI KTALNCNSS*
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: During embryo development, expressed in all cells at the 4- and 16-cell embryo stages. Expression is restricted to the protoderm from the globular stage onward. {ECO:0000269|PubMed:25564655}.
UniprotTISSUE SPECIFICITY: Expressed in apical meristems and young epidermal tissue including trichomes and stipules. Expressed in lateral root tips, the L1 layer of apical inflorescence meristems and early flower primordia, carpel and petal epidermis, stigma papillae, ovule primordia, nucellus and embryo. {ECO:0000269|PubMed:16778018}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor which acts as positive regulator of drought stress tolerance. Can transactivate CIPK3, NCED3 and ERECTA (PubMed:18451323). Transactivates several cell-wall-loosening protein genes by directly binding to HD motifs in their promoters. These target genes play important roles in coordinating cell-wall extensibility with root development and growth (PubMed:24821957). Transactivates CYP74A/AOS, AOC3, OPR3 and 4CLL5/OPCL1 genes by directly binding to HD motifs in their promoters. These target genes are involved in jasmonate (JA) biosynthesis, and JA signaling affects root architecture by activating auxin signaling, which promotes lateral root formation (PubMed:25752924). Acts as negative regulator of trichome branching (PubMed:16778018, PubMed:24824485). Required for the establishment of giant cell identity on the abaxial side of sepals (PubMed:23095885). May regulate cell differentiation and proliferation during root and shoot meristem development (PubMed:25564655). {ECO:0000269|PubMed:16778018, ECO:0000269|PubMed:18451323, ECO:0000269|PubMed:23095885, ECO:0000269|PubMed:24821957, ECO:0000269|PubMed:24824485, ECO:0000269|PubMed:25564655, ECO:0000269|PubMed:25752924}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankLM9999915e-62LM999991.1 Malus baccata partial hdg11 gene for putative homeobox-leucine zipper protein HDG11-like, exons 1-2.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_028948959.10.0homeobox-leucine zipper protein HDG11-like
SwissprotQ9FX310.0HDG11_ARATH; Homeobox-leucine zipper protein HDG11
TrEMBLA0A498I4N90.0A0A498I4N9_MALDO; Uncharacterized protein
STRINGXP_008375041.10.0(Malus domestica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF10263398
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G73360.10.0homeodomain GLABROUS 11
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Khosla A, et al.
    HD-Zip Proteins GL2 and HDG11 Have Redundant Functions in Arabidopsis Trichomes, and GL2 Activates a Positive Feedback Loop via MYB23.
    Plant Cell, 2014. 26(5): p. 2184-2200
    [PMID:24824485]
  3. Horstman A, et al.
    AIL and HDG proteins act antagonistically to control cell proliferation.
    Development, 2015. 142(3): p. 454-64
    [PMID:25564655]
  4. Cai XT,Xu P,Wang Y,Xiang CB
    Activated expression of AtEDT1/HDG11 promotes lateral root formation in Arabidopsis mutant edt1 by upregulating jasmonate biosynthesis.
    J Integr Plant Biol, 2015. 57(12): p. 1017-30
    [PMID:25752924]
  5. Yu LH, et al.
    Arabidopsis EDT1/HDG11 improves drought and salt tolerance in cotton and poplar and increases cotton yield in the field.
    Plant Biotechnol. J., 2016. 14(1): p. 72-84
    [PMID:25879154]
  6. Zhu Z, et al.
    Overexpression of AtEDT1/HDG11 in Chinese Kale (Brassica oleracea var. alboglabra) Enhances Drought and Osmotic Stress Tolerance.
    Front Plant Sci, 2016. 7: p. 1285
    [PMID:27625663]
  7. Liu Y, et al.
    Overexpression of AtEDT1 promotes root elongation and affects medicinal secondary metabolite biosynthesis in roots of transgenic Salvia miltiorrhiza.
    Protoplasma, 2017. 254(4): p. 1617-1625
    [PMID:27915455]
  8. Ueda M, et al.
    Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote.
    Genes Dev., 2017. 31(6): p. 617-627
    [PMID:28404632]
  9. Lung SC, et al.
    Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors.
    New Phytol., 2018. 218(1): p. 183-200
    [PMID:29288621]
  10. Zheng G, et al.
    Over-Expression of Arabidopsis EDT1 Gene Confers Drought Tolerance in Alfalfa (Medicago sativa L.).
    Front Plant Sci, 2017. 8: p. 2125
    [PMID:29326737]