PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Home  TFext  BLAST  Prediction  Download  Help  About  Links  PlantRegMap
(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000734535
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family E2F/DP
Protein Properties Length: 361aa    MW: 39828.8 Da    PI: 10.1012
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000734535genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP71.68.6e-233196171
        E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                   rk+ksL+ll+++fl l+++   + + l+++a++L    v  +rRRiYDi+NVLe+++++++k+kn+++wkg
  MDP0000734535 31 RKQKSLGLLCSNFLGLYNRDGVTSIGLDDAASRL---GV--ERRRIYDIVNVLESVGVLARKAKNQYSWKG 96
                   79*****************999************...**..****************************98 PP
2E2F_TDP74.21.4e-23146228171
        E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.......dvknkrRRiYDilNVLealnliek......kekneirwkg 71 
                    r+eksL lltq+f+kl+ +s+ ++++l+e+ak L+ +           k+RRiYDi+NVL+++nliek      ++k++++w g
  MDP0000734535 146 RREKSLALLTQNFVKLFVCSTVEMISLDEAAKLLLGDahnasvmR-TAKVRRIYDIANVLSSMNLIEKqthtsdTRKPAFKWLG 228
                    689**************************************9752.2589********************************87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.102.4E-252798IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467858.17E-163094IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013723.8E-273196IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.2E-193296IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.101.3E-23142229IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013726.8E-29146228IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.5E-18148228IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467855.69E-13148229IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 361 aa     Download sequence    Send to blast
MADPPPPPPA PAQSSAPAPT GPSARNHGYS RKQKSLGLLC SNFLGLYNRD GVTSIGLDDA  60
ASRLGVERRR IYDIVNVLES VGVLARKAKN QYSWKGFKAI PNALQELRGL QISDDEDDVE  120
RCGSQQTENS NPXLNIKPMN PKSDNRREKS LALLTQNFVK LFVCSTVEMI SLDEAAKLLL  180
GDAHNASVMR TAKVRRIYDI ANVLSSMNLI EKQTHTSDTR KPAFKWLGLR GKEEVPQETK  240
KRAFGTDITN VSSKRGKVDS SIGGKLDGQK QKGLVGEADR SNLEDSKDGS KSYQFGPFAP  300
VTIARAGTGS TRKVHDWEKL TSTYRPQYQN QALKDLFSHY TEAWKTWYSE VAGKNPIRIS  360
*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A3e-35302203228Transcription factor E2F8
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Mdo.115340.0cell culture| fruit
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Not detected during early S phase. Expressed at both the G1/S and S/G2 transitions, with a peak during G2. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:18787127}.
UniprotTISSUE SPECIFICITY: Expressed exclusively in mitotically dividing cells. Highly expressed in young leaves and mature flowers. Lower expression in young stalk and in young and mature flowers. {ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366}.
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_008374484.20.0E2F transcription factor-like E2FE isoform X1
SwissprotQ8LSZ41e-125E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A498I5U60.0A0A498I5U6_MALDO; Uncharacterized protein
STRINGXP_008374484.10.0(Malus domestica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF36683366
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-127DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]