PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

MDP0000650225

Organism

Malus domestica

Taxonomic ID

3750

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus

Family

MYB

Protein Properties

Length: 229aa MW: 25764.5 Da PI: 10.2659

Description

MYB family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
MDP0000650225	genome	GDR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Myb_DNA-binding	47.6	3.9e-15	9	56	1	48
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHHT CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqkyl 48 +g WT eEd +l d+++ +G+g W+++ + g++R++k+c++rw +yl MDP0000650225 9 KGLWTVEEDRILTDYIRVHGKGKWNRVNKVTGLKRSGKSCRLRWMNYL 56 678*******************************************97 PP
2	Myb_DNA-binding	55.3	1.5e-17	62	107	1	48
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHHT CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqkyl 48 r +++eEd+l+++++++ G++ W++Ia +++ gRt++q+k++w+++l MDP0000650225 62 RSDFSEEEDDLIIRLHNLIGNR-WSLIAGRVP-GRTDNQVKNHWNSHL 107 6789****************.*****.**********986 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS51294	15.804	4	56	IPR017930	Myb domain
SuperFamily	SSF46689	4.23E-30	7	103	IPR009057	Homeodomain-like
SMART	SM00717	1.5E-12	8	58	IPR001005	SANT/Myb domain
Pfam	PF00249	2.2E-13	9	56	IPR001005	SANT/Myb domain
Gene3D	G3DSA:1.10.10.60	3.5E-21	10	63	IPR009057	Homeodomain-like
CDD	cd00167	4.50E-10	12	56	No hit	No description
PROSITE profile	PS51294	26.702	57	111	IPR017930	Myb domain
SMART	SM00717	2.9E-16	61	109	IPR001005	SANT/Myb domain
Pfam	PF00249	2.4E-16	62	107	IPR001005	SANT/Myb domain
Gene3D	G3DSA:1.10.10.60	9.3E-26	64	111	IPR009057	Homeodomain-like
CDD	cd00167	5.03E-12	65	107	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 229 aa Download sequence Send to blast
MEGGNEXKKG LWTVEEDRIL TDYIRVHGKG KWNRVNKVTG LKRSGKSCRL RWMNYLSPSV 60 KRSDFSEEED DLIIRLHNLI GNRWSLIAGR VPGRTDNQVK NHWNSHLSKK LGVGSKRGKT 120 KTKTYSDSKR AKNNFCIPSS ESNSELQPLP NSDSNSNISG DHEAAATIDG FDEEMMNIQN 180 HIGSKSEVGF CGMSEXTMMN KSHSHQDKST KINVKSERVR VQQKLPVA*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1a5j_A	1e-27	9	111	7	108	B-MYB
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Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
Mdo.25887	0.0	fruit

Expression -- Description ? help Back to Top
Source	Description
Uniprot	TISSUE SPECIFICITY: Restricted to roots and hypocotyl. Specifically expressed in root non-hair developing cells (atrichoblasts) at the N position. Also present in lateral root cap cells. In hypocotyls, expressed within files of epidermal cells located outside a single cortical cell equivalent to roots N cells (at protein level). {ECO:0000269\|PubMed:10589676, ECO:0000269\|PubMed:14627722, ECO:0000269\|PubMed:16207757}.

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator, when associated with BHLH2/EGL3/MYC146 or BHLH12/MYC1. Involved in epidermal cell fate specification in roots and hypocotyl. Together with GL3 or BHLH2, promotes the formation of non-hair developing cells (atrichoblasts) et the N position in root epidermis. Regulates stomata spatial distribution in hypocotyls. Binds to the WER-binding sites (WBS) promoter regions and activates the transcription of target genes such as GL2 and of CPC. {ECO:0000269\|PubMed:10589676, ECO:0000269\|PubMed:11585796, ECO:0000269\|PubMed:14627722, ECO:0000269\|PubMed:15361138, ECO:0000269\|PubMed:15795220, ECO:0000269\|PubMed:16207757}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Transcriptional activation correlates with reduced histone acetylation on H3 and H4 mediated by HDA18 in N cells. Repressed by CPC in hair cells (H position). {ECO:0000269\|PubMed:11910008, ECO:0000269\|PubMed:16176989}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_008393037.2	1e-145	transcription factor WER-like
Swissprot	Q9SEI0	2e-64	WER_ARATH; Transcription factor WER
TrEMBL	A0A498I626	1e-144	A0A498I626_MALDO; Uncharacterized protein
STRING	XP_008393037.1	1e-144	(Malus domestica)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF31	34	817

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G14750.1	7e-67	myb domain protein 66

Link Out ? help Back to Top
Phytozome	MDP0000650225

Publications ? help Back to Top
Savage N, et al. Positional signaling and expression of ENHANCER OF TRY AND CPC1 are tuned to increase root hair density in response to phosphate deficiency in Arabidopsis thaliana. PLoS ONE, 2013. 8(10): p. e75452 [PMID:24130712] Cheng Y, et al. Brassinosteroids control root epidermal cell fate via direct regulation of a MYB-bHLH-WD40 complex by GSK3-like kinases. Elife, 2018. [PMID:24771765] Kiefer CS, et al. Correction: Arabidopsis AIP1-2 restricted by WER-mediated patterning modulates planar polarity. Development, 2015. 142(5): p. 1022 [PMID:25715402] Kwak SH,Song SK,Lee MM,Schiefelbein J TORNADO1 regulates root epidermal patterning through the WEREWOLF pathway in Arabidopsis thaliana. Plant Signal Behav, 2015. 10(12): p. e1103407 [PMID:26451798] Zhu Y, et al. The Histone Chaperone NRP1 Interacts with WEREWOLF to Activate GLABRA2 in Arabidopsis Root Hair Development. Plant Cell, 2017. 29(2): p. 260-276 [PMID:28138017] Canales J,Contreras-López O,Álvarez JM,Gutiérrez RA Nitrate induction of root hair density is mediated by TGA1/TGA4 and CPC transcription factors in Arabidopsis thaliana. Plant J., 2017. 92(2): p. 305-316 [PMID:28771873] Mira MM, et al. Expression of Arabidopsis class 1 phytoglobin (AtPgb1) delays death and degradation of the root apical meristem during severe PEG-induced water deficit. J. Exp. Bot., 2017. 68(20): p. 5653-5668 [PMID:29059380] Kohanová J, et al. Root hair abundance impacts cadmium accumulation in Arabidopsis thaliana shoots. Ann. Bot., 2018. 122(5): p. 903-914 [PMID:29394308]