PlantRegMap/PlantTFDB v5.0
Plant Transcription
Factor Database
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Transcription Factor Information
Basic Information? help Back to Top | |||||||||
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TF ID | MDP0000646823 | ||||||||
Organism | |||||||||
Taxonomic ID | |||||||||
Taxonomic Lineage |
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
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Family | bHLH | ||||||||
Protein Properties | Length: 451aa MW: 50267.4 Da PI: 4.7288 | ||||||||
Description | bHLH family protein | ||||||||
Gene Model |
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Signature Domain? help Back to Top | |||||||
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No. | Domain | Score | E-value | Start | End | HMM Start | HMM End |
1 | HLH | 37.9 | 3.3e-12 | 231 | 282 | 1 | 55 |
CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS HLH 1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 +r++h ++Er+RR+++N+ + Lr+l+P + + ++ + a+i A+e++++L+ MDP0000646823 231 QRMTHIAVERNRRKQMNEHLRVLRSLMPGS---YVQRGDQASIIGGAIEFVRELE 282 79****************************...9*****************9995 PP |
Protein Features ? help Back to Top | ||||||
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Database | Entry ID | E-value | Start | End | InterPro ID | Description |
Gene3D | G3DSA:4.10.280.10 | 1.6E-13 | 229 | 285 | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
CDD | cd00083 | 2.03E-13 | 229 | 286 | No hit | No description |
SuperFamily | SSF47459 | 1.7E-16 | 230 | 298 | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
PROSITE profile | PS50888 | 15.428 | 230 | 281 | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
Pfam | PF00010 | 1.5E-9 | 231 | 282 | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
SMART | SM00353 | 3.4E-9 | 236 | 287 | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
CDD | cd04873 | 0.00756 | 375 | 439 | No hit | No description |
Gene Ontology ? help Back to Top | ||||||
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GO Term | GO Category | GO Description | ||||
GO:0010377 | Biological Process | guard cell fate commitment | ||||
GO:0045597 | Biological Process | positive regulation of cell differentiation | ||||
GO:0045893 | Biological Process | positive regulation of transcription, DNA-templated | ||||
GO:0051782 | Biological Process | negative regulation of cell division | ||||
GO:0005634 | Cellular Component | nucleus | ||||
GO:0046983 | Molecular Function | protein dimerization activity |
Sequence ? help Back to Top |
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Protein Sequence Length: 451 aa Download sequence Send to blast |
MLFFCSDDFE TLQAFMPPSN FNNLDYTLDH HQEDQQMMKS RVDETNSSDN NNGMVNYLMY 60 NHHQLQQQQQ QQQISTQLAP AGFCGSTSTS FDKLSFADVM QFADFGPKLA LNQTKISEEE 120 PAIDPVYFLK FPVLNDKLDN NQDQSISLMV PQAEERFTGL GEEDKTKSME EEQDEEGPVS 180 GSNNSVQKIH FLGEDLQNNP IGGGVQPEPA AAKNKRKRPR TTKTTQEVES QRMTHIAVER 240 NRRKQMNEHL RVLRSLMPGS YVQRGDQASI IGGAIEFVRE LEQLLQCLES QKRRRLLGEA 300 PPRQVGDSAT AAAMAVQAAE GGGGPLIFPA ANLPITNPND PIKFVDYETG LREETAENKS 360 CFADVEVKVL GFDAMIKILS QRRPGQLIKA IAALEDLQLN ILHTNITTIE QTVLYSFNVK 420 VGSESRFTAE DIASSVQQIF SFIHANTASM * |
Nucleic Localization Signal ? help Back to Top | |||
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No. | Start | End | Sequence |
1 | 231 | 242 | RMTHIAVERNRR |
2 | 291 | 295 | KRRRL |
Expression -- Description ? help Back to Top | ||||||
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Source | Description | |||||
Uniprot | DEVELOPMENTAL STAGE: Not expressed in meristemoids, but strongly expressed in guard mother cells (GMCs) and in young guard cells (at protein level) (PubMed:17088607). Expressed at the transition to terminal stomatal differentiation, just before and after the symmetric division of stomatal differentiation, being confined to late-stage GMC and to young, still differentiating guard cells (PubMed:24571519). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:24571519}. | |||||
Uniprot | TISSUE SPECIFICITY: Resctricted to stomatal cell lineages (at protein level). Expressed in roots, leaves, stems, and flowers. {ECO:0000269|PubMed:12679534, ECO:0000269|PubMed:17088607}. |
Functional Description ? help Back to Top | ||||||
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Source | Description | |||||
UniProt | Transcription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}. |
Regulation -- Description ? help Back to Top | ||||||
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Source | Description | |||||
UniProt | INDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}. |
Regulation -- PlantRegMap ? help Back to Top | ||||||
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Source | Upstream Regulator | Target Gene | ||||
PlantRegMap | Retrieve | - |
Annotation -- Protein ? help Back to Top | |||||||
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Source | Hit ID | E-value | Description | ||||
Refseq | XP_017189946.1 | 0.0 | transcription factor FAMA isoform X1 | ||||
Swissprot | Q56YJ8 | 1e-142 | FAMA_ARATH; Transcription factor FAMA | ||||
TrEMBL | A0A498K498 | 0.0 | A0A498K498_MALDO; Uncharacterized protein | ||||
STRING | XP_008380575.1 | 0.0 | (Malus domestica) |
Orthologous Group ? help Back to Top | |||
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Lineage | Orthologous Group ID | Taxa Number | Gene Number |
Fabids | OGEF10489 | 33 | 40 |
Best hit in Arabidopsis thaliana ? help Back to Top | ||||||
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Hit ID | E-value | Description | ||||
AT3G24140.1 | 1e-123 | bHLH family protein |
Link Out ? help Back to Top | |
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Phytozome | MDP0000646823 |