PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000525933
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family ERF
Protein Properties Length: 281aa    MW: 31190.9 Da    PI: 9.1009
Description ERF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000525933genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1AP259.21e-182878155
            AP2  1 sgykGVrwdkkrgrWvAeIrd.psengkrkrfslgkfgtaeeAakaaiaarkkleg 55
                   +++ GVr+++ +g+WvAeI+d      k+ r +lg+f taeeAa+a+++a+  l+g
  MDP0000525933 28 CKFVGVRQRP-SGKWVAEIKDtT----KKIRMWLGTFETAEEAARAYDEAAYLLRG 78
                   799*******.7*********33....36**********************99997 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd000185.38E-322885No hitNo description
PfamPF008472.8E-132878IPR001471AP2/ERF domain
Gene3DG3DSA:3.30.730.101.6E-282986IPR001471AP2/ERF domain
SMARTSM003801.1E-362992IPR001471AP2/ERF domain
SuperFamilySSF541714.45E-202987IPR016177DNA-binding domain
PROSITE profilePS5103220.4552986IPR001471AP2/ERF domain
PRINTSPR003674.8E-83041IPR001471AP2/ERF domain
PRINTSPR003674.8E-85268IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0000302Biological Processresponse to reactive oxygen species
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009723Biological Processresponse to ethylene
GO:0035865Biological Processcellular response to potassium ion
GO:0048528Biological Processpost-embryonic root development
GO:0005634Cellular Componentnucleus
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 281 aa     Download sequence    Send to blast
MEHQAPKQQK GVFANKQGKS KERTKSKCKF VGVRQRPSGK WVAEIKDTTK KIRMWLGTFE  60
TAEEAARAYD EAAYLLRGSN TRTNFSTHVP SNSPLSLKIR NLLNQKKGLK QSPXSSNPNX  120
LNXTPIATTA XITNKYTTFS DGSXNSIATF SEIFLPNCKS QKNVQVFDDA YRPDVSNCIG  180
VLQPGLFHNH FGRQWPLLTG FDQLPVTHEG NDLAKDIGMT SSPNVAAEPE VTEFERLKVE  240
RQISASIYAM NGVNEYLDNG YDSGDALWDL PSLSQLFCLG *
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1gcc_A9e-163089363ETHYLENE RESPONSIVE ELEMENT BINDING FACTOR 1
5wx9_A1e-1529851471Ethylene-responsive transcription factor ERF096
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in roots, root hairs and leaves (PubMed:17827349). Expressed in root epidermis and root hairs (PubMed:23077241). {ECO:0000269|PubMed:17827349, ECO:0000269|PubMed:23077241}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor involved in symbiotic nodule signaling in response to rhizobial Nod factors (NFs) (PubMed:17449807, PubMed:17827349). Binds to the GCC-box (NF-responsive box) of ENOD11 promoter. Acts as transcriptional activator of NF-responsive box-containing target gene promoters in root hairs (PubMed:17827349). Functions as a transcriptional regulator required for root infection by symbiotic rhizobia, infection thread (IT) formation and maintenance, and nodule development. Necessary for NF-induced gene expression and spontaneous nodulation activated by CCAMK. Functions downstream of CCAMK to activate nodulation gene expression (PubMed:17449807). Involved in early stages of root nodule development. Functions redundantly with ERN2. Is essential with ERN2 for the initiation of root hair infection, and nodule organogenesis and development. Required for accurate expression of the NF signaling genes ENOD11 and ENOD12 (PubMed:23077241, PubMed:27208242). {ECO:0000269|PubMed:17449807, ECO:0000269|PubMed:17827349, ECO:0000269|PubMed:23077241, ECO:0000269|PubMed:27208242}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00521DAPTransfer from AT5G19790Download
Motif logo
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced in roots from 1 to 21 day after inoculation with Sinorhizobium meliloti (PubMed:17449807). Induced by Nod factors in root hairs (PubMed:17827349). {ECO:0000269|PubMed:17449807, ECO:0000269|PubMed:17827349}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_008351488.20.0ethylene-responsive transcription factor ERN1-like
SwissprotA2Q5W17e-75ERN1_MEDTR; Ethylene-responsive transcription factor ERN1
TrEMBLA0A498K8M90.0A0A498K8M9_MALDO; Uncharacterized protein
STRINGXP_008351488.10.0(Malus domestica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF33413069
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G19790.12e-54related to AP2 11
Publications ? help Back to Top
  1. Cerri MR, et al.
    Medicago truncatula ERN transcription factors: regulatory interplay with NSP1/NSP2 GRAS factors and expression dynamics throughout rhizobial infection.
    Plant Physiol., 2012. 160(4): p. 2155-72
    [PMID:23077241]
  2. Tang H, et al.
    An improved genome release (version Mt4.0) for the model legume Medicago truncatula.
    BMC Genomics, 2014. 15: p. 312
    [PMID:24767513]
  3. Cerri MR, et al.
    The Symbiosis-Related ERN Transcription Factors Act in Concert to Coordinate Rhizobial Host Root Infection.
    Plant Physiol., 2016. 171(2): p. 1037-54
    [PMID:27208242]