PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000453148
Common NameC2H2L20
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family C2H2
Protein Properties Length: 528aa    MW: 58713.3 Da    PI: 6.3984
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000453148genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H220.99.5e-07271292223
                    EETTTTEEESSHHHHHHHHHHT CS
        zf-C2H2   2 kCpdCgksFsrksnLkrHirtH 23 
                     C +Cgk F+r  nL+ H+r H
  MDP0000453148 271 FCAICGKGFKRDANLRMHMRGH 292
                    6*******************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF576673.46E-5268296No hitNo description
PROSITE profilePS5015711.884270297IPR007087Zinc finger, C2H2
SMARTSM003550.012270292IPR015880Zinc finger, C2H2-like
PfamPF128740.0012271292No hitNo description
Gene3DG3DSA:3.30.160.601.1E-5271321IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE patternPS000280272292IPR007087Zinc finger, C2H2
SMARTSM0035553319352IPR015880Zinc finger, C2H2-like
SMARTSM0035522357379IPR015880Zinc finger, C2H2-like
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0010044Biological Processresponse to aluminum ion
GO:0010447Biological Processresponse to acidic pH
GO:0005634Cellular Componentnucleus
GO:0003676Molecular Functionnucleic acid binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0046872Molecular Functionmetal ion binding
Sequence ? help Back to Top
Protein Sequence    Length: 528 aa     Download sequence    Send to blast
MDPKERQWDT WENPSTGNDV TNTISSDHPS FTNFNSQQHQ REWERPSVLD YEMRMEPSFL  60
KFHQPSDSQM SYTCNSKNDT KIPDQEGGKM HEVQQPNKIQ DWDARMTLNN LTFLEQKIHQ  120
LQDLVHVIVG RRGQVLGRPD ELVAQQQQLI TADLTSIIAQ LISTAGSLLP SVKHTLSTTL  180
PSTGQFGQLG GSFIPSAAGN DAGVKMQINS GSKLADQANQ TDLISNYGTE HIEEHETKDE  240
EDADEGENLP PGSYEILQLE KEEILAPHTH FCAICGKGFK RDANLRMHMR GHGDEYKTAA  300
ALAKPNKESS SEPTLIKRYS CPYAGCKRNK DHKKFQPLKT ILCVKNHYKR THCDKSYTCS  360
RCNTKKFSVI ADLKTHEKHC GIDKWLCSCG TTFSRKDKLF GHITLFQGHT PAIPLDETKG  420
TLGPADHGEG SEASNRVGSI SFSVSSTAPG GGGAAQSLMD VKESIDDPTS YFSPLNFETC  480
NFDGFQEFPR PPFEDTESSF SFLMPGSCNY THKTGGGESN FNNLHRQ*
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Mdo.80500.0bud| cell culture| fruit| leaf
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in roots (e.g. root tips and lateral roots), leaves, flowers (e.g. stigma, sepal, anther, and filament), stems, siliques and cotyledons. {ECO:0000269|PubMed:23935008}.
Functional Description ? help Back to Top
Source Description
UniProtProbable transcription factor. Together with STOP2, plays a critical role in tolerance to major stress factors in acid soils such as proton H(+) and aluminum ion Al(3+). Required for the expression of genes in response to acidic stress (e.g. ALMT1 and MATE), and Al-activated citrate exudation. {ECO:0000269|PubMed:17535918, ECO:0000269|PubMed:18826429, ECO:0000269|PubMed:19321711, ECO:0000269|PubMed:23935008}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00196ampDAPTransfer from AT1G34370Download
Motif logo
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By shock H(+) and Al(3+) treatments. {ECO:0000269|PubMed:17535918}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_001315915.10.0protein SENSITIVE TO PROTON RHIZOTOXICITY 1
SwissprotQ9C8N50.0STOP1_ARATH; Protein SENSITIVE TO PROTON RHIZOTOXICITY 1
TrEMBLA0A498K4R00.0A0A498K4R0_MALDO; Uncharacterized protein
STRINGXP_008381003.10.0(Malus domestica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF53403254
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G34370.20.0C2H2 family protein
Publications ? help Back to Top
  1. Kobayashi Y, et al.
    Molecular and physiological analysis of Al³⁺ and H⁺ rhizotoxicities at moderately acidic conditions.
    Plant Physiol., 2013. 163(1): p. 180-92
    [PMID:23839867]
  2. Yokosho K,Yamaji N,Ma JF
    Global transcriptome analysis of Al-induced genes in an Al-accumulating species, common buckwheat (Fagopyrum esculentum Moench).
    Plant Cell Physiol., 2014. 55(12): p. 2077-91
    [PMID:25273892]
  3. Geng X, et al.
    LEUNIG_HOMOLOG transcriptional co-repressor mediates aluminium sensitivity through PECTIN METHYLESTERASE46-modulated root cell wall pectin methylesterification in Arabidopsis.
    Plant J., 2017. 90(3): p. 491-504
    [PMID:28181322]
  4. Balzergue C, et al.
    Low phosphate activates STOP1-ALMT1 to rapidly inhibit root cell elongation.
    Nat Commun, 2017. 8: p. 15300
    [PMID:28504266]
  5. Pelagio-Flores R,Esparza-Reynoso S,Garnica-Vergara A,López-Bucio J,Herrera-Estrella A
    Trichoderma-Induced Acidification Is an Early Trigger for Changes in Arabidopsis Root Growth and Determines Fungal Phytostimulation.
    Front Plant Sci, 2017. 8: p. 822
    [PMID:28567051]
  6. Jiang F, et al.
    Identification and characterization of suppressor mutants of stop1.
    BMC Plant Biol., 2017. 17(1): p. 128
    [PMID:28738784]
  7. Daspute AA, et al.
    Transcriptional Regulation of Aluminum-Tolerance Genes in Higher Plants: Clarifying the Underlying Molecular Mechanisms.
    Front Plant Sci, 2017. 8: p. 1358
    [PMID:28848571]
  8. Sharma A,Wai CM,Ming R,Yu Q
    Diurnal Cycling Transcription Factors of Pineapple Revealed by Genome-Wide Annotation and Global Transcriptomic Analysis.
    Genome Biol Evol, 2017. 9(9): p. 2170-2190
    [PMID:28922793]
  9. Zhang Y, et al.
    The Cell Cycle Checkpoint Regulator ATR Is Required for Internal Aluminum Toxicity-Mediated Root Growth Inhibition in Arabidopsis.
    Front Plant Sci, 2018. 9: p. 118
    [PMID:29491872]