PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000426630
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family HD-ZIP
Protein Properties Length: 810aa    MW: 88760.4 Da    PI: 6.4098
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000426630genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox57.91.7e-182683457
                   -SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHC....TS-HHHHHHHHHHHHHHHHC CS
       Homeobox  4 RttftkeqleeLeelFeknrypsaeereeLAkkl....gLterqVkvWFqNrRakekk 57
                     ++t+eq+e+Le++++++++ps  +r++L +++    +++ rq+kvWFqNrR +ek+
  MDP0000426630 26 YVRYTSEQVEALERVYAECPKPSSLRRQQLIRECpilsNIEPRQIKVWFQNRRCREKQ 83
                   5789****************************************************97 PP
2START160.21.6e-501643712204
                    HHHHHHHHHHHHHHHC-TT-EEEEEXCCTTEEEEEEESSS.SCEEEEEEEECCSCHHHHHHHHHCCCGGCT-TT-SEEEEEEEECTT..EEEEEEE CS
          START   2 laeeaaqelvkkalaeepgWvkssesengdevlqkfeeskvdsgealrasgvvdmvlallveellddkeqWdetlakaetlevissg..galqlmv 95 
                    +aee+++e+++ka+ ++  Wv+++ +++g++++ +f+ s+++sg a+ra+g+v  +++   +e+l+d++ W +++++ e+      g  g+++l++
  MDP0000426630 164 IAEETLAEFLSKATGTAVDWVQMPGMKPGPDSVGIFAISQSCSGVAARACGLVSLEPT-KIAEILKDRPSWFRDCRSLEVFTMFPAGngGTIELIY 258
                    7899******************************************************.7777777777***********999999999******* PP

                    EXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--....-TTSEE-EESSEEEEEEEECTCEEEEEEEE-EE--SSXXHHHHHHHHHH CS
          START  96 aelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppe...sssvvRaellpSgiliepksnghskvtwvehvdlkgrlphwllrslvks 187
                    ++++a+++l+p Rdf+++Ry+ +l  g++v++++S++     p+    s++vR+ +lpSg+li+p+++g+s +++v+h +l++++++++lr+l++s
  MDP0000426630 259 TQTYAPTTLAPaRDFWTLRYTTTLDNGSFVVCERSLSGSGAGPNpasASQFVRGAMLPSGYLIRPCEGGGSIIHIVDHLNLEAWSVPEVLRPLYES 354
                    *************************************988888878999*********************************************** PP

                    HHHHHHHHHHHHTXXXX CS
          START 188 glaegaktwvatlqrqc 204
                    + + +++++ a+l++ +
  MDP0000426630 355 SKVVAQRMTIAALRYIR 371
                    ************99865 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5007115.3862084IPR001356Homeobox domain
SMARTSM003899.1E-162288IPR001356Homeobox domain
SuperFamilySSF466893.12E-162486IPR009057Homeodomain-like
CDDcd000861.52E-162585No hitNo description
PfamPF000464.0E-162683IPR001356Homeobox domain
Gene3DG3DSA:1.10.10.601.1E-182783IPR009057Homeodomain-like
CDDcd146861.37E-577116No hitNo description
PROSITE profilePS5084827.666154382IPR002913START domain
CDDcd088751.09E-69158374No hitNo description
Gene3DG3DSA:3.30.530.203.2E-20163349IPR023393START-like domain
SMARTSM002344.3E-42163373IPR002913START domain
SuperFamilySSF559611.37E-34163375No hitNo description
PfamPF018524.3E-48164371IPR002913START domain
PfamPF086707.1E-30710808IPR013978MEKHLA
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0003677Molecular FunctionDNA binding
GO:0008289Molecular Functionlipid binding
Sequence ? help Back to Top
Protein Sequence    Length: 810 aa     Download sequence    Send to blast
MAXVVAXHRE SSSGSSINKH LDAGKYVRYT SEQVEALERV YAECPKPSSL RRQQLIRECP  60
ILSNIEPRQI KVWFQNRRCR EKQRKESSRL QIVNRKLSAM NKLLMEENDR LQKQVSQLVC  120
ENGYMRQQLH TAPAATTDAS CDSLVTTPQH SLRDANNPAG LLSIAEETLA EFLSKATGTA  180
VDWVQMPGMK PGPDSVGIFA ISQSCSGVAA RACGLVSLEP TKIAEILKDR PSWFRDCRSL  240
EVFTMFPAGN GGTIELIYTQ TYAPTTLAPA RDFWTLRYTT TLDNGSFVVC ERSLSGSGAG  300
PNPASASQFV RGAMLPSGYL IRPCEGGGSI IHIVDHLNLE AWSVPEVLRP LYESSKVVAQ  360
RMTIAALRYI RQIAQETSGE VVYSLGRQPA VLRTFSQRLI RGFNDAVNGF NDDGWSLVNC  420
DGAEDVIITV NSTKNLTSTS NHANSLALLG GXLCAKASML LQNVPPAVLX RFLREHRSEW  480
ADFNVDAYSA ASLKAGSYAY PGMRPTRFTG GQIIMPLGHT IEQEELLEVV RLEGHSLTQE  540
DAFASRDIHL LQICSGVDEN AAGACSELVF APIDEMFPDD APLLPSGFRI IPLDSKTSDS  600
RATLNTHRTL DLASSLEVGS TTSNAAGDLT TFHNTRSVLT IAFQFPLDNX LQENVANMAR  660
QYVRSVISSV QRVAMAISPS GLSPSVXPKL SPSSPEADTL AHWICQSYRQ SMPVFTFANQ  720
AGLDMLETTL VALQDISLDK IFDEAGRKTL CADFSKLMNQ GFAYLPAGIC MSTMARHVSY  780
EQAIAWKVLA AEENCVHCLA FSFINWSFV*
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Mdo.166090.0bud| fruit| leaf| stem
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed at the earliest stages and throughout LSM initiation and development. In embryo development, expressed at the heart stage until the 'walking stick' stage in the adaxial portion of the cotyledon primordia, the shoot apical meristem (SAM) and the vascular precursor cells of the hypocotyl and root. In developing flowers, expressed first at stage 1 in the center of L3 layer and then expands to the center of L2 and L1 layers. Expressed in the center of flower meristem through stages 4 and 5. At stage 6, expressed in the adaxial side of the carpel primordia and then on the adaxial carpel face. {ECO:0000269|PubMed:11169198}.
UniprotTISSUE SPECIFICITY: Expressed in the interfascicular regions of stem and vascular bundles of young roots and leaves. {ECO:0000269|PubMed:10559440}.
Functional Description ? help Back to Top
Source Description
UniProtProbable transcription factor involved in the regulation of interfascicular fiber (cortical cells) and secondary xylem differentiation in the inflorescence stems. Required for lateral shoot meristems (LSMs) and flower meristems (FMs) initiation. May be involved in the determination of vascular patterning and organ polarity (PubMed:10559440, PubMed:11169198, PubMed:11402186, PubMed:15111711, PubMed:15598805, PubMed:7555701). Directly regulates the expression of AGO10, ZPR1, ZPR2, ZPR3 and ZPR4 (PubMed:22781836). Required to regulate adaxial-abaxial polarity and leaf axial patterning (PubMed:20807212). {ECO:0000269|PubMed:10559440, ECO:0000269|PubMed:11169198, ECO:0000269|PubMed:11402186, ECO:0000269|PubMed:15111711, ECO:0000269|PubMed:15598805, ECO:0000269|PubMed:20807212, ECO:0000269|PubMed:22781836, ECO:0000269|PubMed:7555701}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By auxin. Repressed by ZPR and miR165. Induced by DOF5.1 (PubMed:20807212). {ECO:0000269|PubMed:15111711, ECO:0000269|PubMed:17237362, ECO:0000269|PubMed:20807212}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankFJ1774250.0FJ177425.1 Malus x domestica putative REV HD-ZipIII mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_008344872.20.0homeobox-leucine zipper protein REVOLUTA-like
SwissprotQ9SE430.0REV_ARATH; Homeobox-leucine zipper protein REVOLUTA
TrEMBLA0A498K8I50.0A0A498K8I5_MALDO; Uncharacterized protein
STRINGXP_008344872.10.0(Malus domestica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF66333147
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G60690.10.0HD-ZIP family protein
Publications ? help Back to Top
  1. Varkonyi-Gasic E,Gould N,Sandanayaka M,Sutherland P,MacDiarmid RM
    Characterisation of microRNAs from apple (Malus domestica 'Royal Gala') vascular tissue and phloem sap.
    BMC Plant Biol., 2010. 10: p. 159
    [PMID:20682080]
  2. Lian H,Li X,Liu Z,He Y
    HYL1 is required for establishment of stamen architecture with four microsporangia in Arabidopsis.
    J. Exp. Bot., 2013. 64(11): p. 3397-410
    [PMID:23918970]
  3. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  4. Baima S, et al.
    Negative feedback regulation of auxin signaling by ATHB8/ACL5-BUD2 transcription module.
    Mol Plant, 2014. 7(6): p. 1006-1025
    [PMID:24777988]
  5. Jia X, et al.
    Functional plasticity of miR165/166 in plant development revealed by small tandem target mimic.
    Plant Sci., 2015. 233: p. 11-21
    [PMID:25711809]
  6. Roodbarkelari F,Du F,Truernit E,Laux T
    ZLL/AGO10 maintains shoot meristem stem cells during Arabidopsis embryogenesis by down-regulating ARF2-mediated auxin response.
    BMC Biol., 2015. 13: p. 74
    [PMID:26358077]
  7. Shi B, et al.
    Two-Step Regulation of a Meristematic Cell Population Acting in Shoot Branching in Arabidopsis.
    PLoS Genet., 2016. 12(7): p. e1006168
    [PMID:27398935]