PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

MDP0000403580

Common Name

AP2D55

Organism

Malus domestica

Taxonomic ID

3750

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus

Family

ERF

Protein Properties

Length: 387aa MW: 43102.6 Da PI: 4.4233

Description

ERF family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
MDP0000403580	genome	GDR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	AP2	60.9	2.9e-19	113	162	2	55
AP2 2 gykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55 +y+G+r+++ +g+W+AeIrdp++ r++lg+f taeeAa+a++a +++++g MDP0000403580 113 QYRGIRQRP-WGKWAAEIRDPRK---GVRVWLGTFNTAEEAARAYDAEARRIRG 162 69*****.******954...4**********************998 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:3.30.730.10	2.5E-32	113	171	IPR001471	AP2/ERF domain
SMART	SM00380	1.4E-37	113	176	IPR001471	AP2/ERF domain
PROSITE profile	PS51032	24.092	113	170	IPR001471	AP2/ERF domain
SuperFamily	SSF54171	4.25E-22	113	171	IPR016177	DNA-binding domain
CDD	cd00018	1.34E-32	113	171	No hit	No description
PRINTS	PR00367	1.2E-11	114	125	IPR001471	AP2/ERF domain
Pfam	PF00847	8.8E-12	114	162	IPR001471	AP2/ERF domain
PRINTS	PR00367	1.2E-11	136	152	IPR001471	AP2/ERF domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0070483	Biological Process	detection of hypoxia
GO:0005634	Cellular Component	nucleus
GO:0005886	Cellular Component	plasma membrane
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 387 aa Download sequence Send to blast
MCGGAIISDF IAPVRSRRLT ADYLWPDLKK PSSGKRLSKP LKSEIVDLDD DFEADFQEFK 60 DESDVDEDDE MVDXKPSAFS AGNPSFARGS TAVKSVEFDG QAEKSAKRKR KNQYRGIRQR 120 PWGKWAAEIR DPRKGVRVWL GTFNTAEEAA RAYDAEARRI RGKKAKVNFP EETPCASAKR 180 SIKENPQKLI AKTNLNGTQS NXNQNFNFVN DSSEDYYSAL GFLDEKPTMN NFRYMSTFPA 240 NEDVALKSSV PSENAPFYFS SDQGSNSFDC SDFGWGEQGS KTPEISSVIS SVMEESDNSX 300 FLEDSNPTKK MKPNSQDLEP PEDNSGKTLS DELSAFEMKY FQTPYLDESW DASVDAFLNG 360 DATQDGGNPM DLWSFDDLPA IVGGVF*

Sequence ? help Back to Top

Protein Sequence Length: 387 aa Download sequence Send to blast

MCGGAIISDF IAPVRSRRLT ADYLWPDLKK PSSGKRLSKP LKSEIVDLDD DFEADFQEFK  60
DESDVDEDDE MVDXKPSAFS AGNPSFARGS TAVKSVEFDG QAEKSAKRKR KNQYRGIRQR  120
PWGKWAAEIR DPRKGVRVWL GTFNTAEEAA RAYDAEARRI RGKKAKVNFP EETPCASAKR  180
SIKENPQKLI AKTNLNGTQS NXNQNFNFVN DSSEDYYSAL GFLDEKPTMN NFRYMSTFPA  240
NEDVALKSSV PSENAPFYFS SDQGSNSFDC SDFGWGEQGS KTPEISSVIS SVMEESDNSX  300
FLEDSNPTKK MKPNSQDLEP PEDNSGKTLS DELSAFEMKY FQTPYLDESW DASVDAFLNG  360
DATQDGGNPM DLWSFDDLPA IVGGVF*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5wx9_A	3e-21	112	178	13	80	Ethylene-responsive transcription factor ERF096
Search in ModeBase

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
Mdo.7198	0.0	bud\| cell culture\| fruit\| leaf\| root\| stem

Expression -- Description ? help Back to Top
Source	Description
Uniprot	TISSUE SPECIFICITY: Highly expressed in seedlings, leaves, flowers, siliques and germinating seeds. {ECO:0000269\|PubMed:22020282}.

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor involved in the activation of hypoxic gene expression and in ethylene response. Partially redundant with RAP2-2. Acts as a downstream regulator in the ethylene signaling pathway. {ECO:0000269\|PubMed:22020282, ECO:0000269\|PubMed:22530619}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00204	DAP	Transfer from AT1G53910	Download

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by hypoxia but not by ethylene. {ECO:0000269\|PubMed:22020282}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	GU732479	0.0	GU732479.1 Malus x domestica AP2 domain class transcription factor (AP2D55) mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_001280975.1	0.0	ethylene-responsive transcription factor RAP2-12-like
Swissprot	Q9SSA8	9e-93	RA212_ARATH; Ethylene-responsive transcription factor RAP2-12
TrEMBL	A0A498IZQ8	0.0	A0A498IZQ8_MALDO; Uncharacterized protein
STRING	XP_008380747.1	0.0	(Malus domestica)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF4808	32	52

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G53910.2	9e-88	related to AP2 12

Link Out ? help Back to Top
Phytozome	MDP0000403580
Entrez Gene	103443637

Publications ? help Back to Top
Tacken E, et al. The role of ethylene and cold temperature in the regulation of the apple POLYGALACTURONASE1 gene and fruit softening. Plant Physiol., 2010. 153(1): p. 294-305 [PMID:20237022] Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Kosmacz M, et al. The stability and nuclear localization of the transcription factor RAP2.12 are dynamically regulated by oxygen concentration. Plant Cell Environ., 2015. 38(6): p. 1094-103 [PMID:25438831] Bui LT,Giuntoli B,Kosmacz M,Parlanti S,Licausi F Constitutively expressed ERF-VII transcription factors redundantly activate the core anaerobic response in Arabidopsis thaliana. Plant Sci., 2015. 236: p. 37-43 [PMID:26025519] Gasch P, et al. Redundant ERF-VII Transcription Factors Bind to an Evolutionarily Conserved cis-Motif to Regulate Hypoxia-Responsive Gene Expression in Arabidopsis. Plant Cell, 2016. 28(1): p. 160-80 [PMID:26668304] Gonzali S, et al. Universal stress protein HRU1 mediates ROS homeostasis under anoxia. Nat Plants, 2015. 1: p. 15151 [PMID:27251529] Paul MV, et al. Oxygen Sensing via the Ethylene Response Transcription Factor RAP2.12 Affects Plant Metabolism and Performance under Both Normoxia and Hypoxia. Plant Physiol., 2016. 172(1): p. 141-53 [PMID:27372243] Shahzad Z, et al. A Potassium-Dependent Oxygen Sensing Pathway Regulates Plant Root Hydraulics. Cell, 2016. 167(1): p. 87-98.e14 [PMID:27641502] Yao Y, et al. ETHYLENE RESPONSE FACTOR 74 (ERF74) plays an essential role in controlling a respiratory burst oxidase homolog D (RbohD)-dependent mechanism in response to different stresses in Arabidopsis. New Phytol., 2017. 213(4): p. 1667-1681 [PMID:28164334] Giuntoli B,Licausi F,van Veen H,Perata P Functional Balancing of the Hypoxia Regulators RAP2.12 and HRA1 Takes Place in vivo in Arabidopsis thaliana Plants. Front Plant Sci, 2017. 8: p. 591 [PMID:28487707] Yao Y,Chen X,Wu AM ERF-VII members exhibit synergistic and separate roles in Arabidopsis. Plant Signal Behav, 2017. 12(6): p. e1329073 [PMID:28537474] Eysholdt-Derzsó E,Sauter M Root Bending Is Antagonistically Affected by Hypoxia and ERF-Mediated Transcription via Auxin Signaling. Plant Physiol., 2017. 175(1): p. 412-423 [PMID:28698356] Giuntoli B, et al. Age-dependent regulation of ERF-VII transcription factor activity in Arabidopsis thaliana. Plant Cell Environ., 2017. 40(10): p. 2333-2346 [PMID:28741696]