PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000316609
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family MIKC_MADS
Protein Properties Length: 239aa    MW: 27559.7 Da    PI: 8.3039
Description MIKC_MADS family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000316609genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1SRF-TF76.81.6e-24957149
                   S---SHHHHHHHHHHHHHHHHHHHHHHHHHHT-EEEEEEE-TTSEEEEE CS
         SRF-TF  1 krienksnrqvtfskRrngilKKAeELSvLCdaevaviifsstgklyey 49
                   krien   rqvtf+kRr g+lKKA+ELSvLCdae+ v ifss+gkl+e 
  MDP0000316609  9 KRIENPVHRQVTFCKRRVGLLKKAKELSVLCDAEIGVFIFSSHGKLFEL 57
                   79********************************************996 PP
2K-box52.71.8e-1812621214100
          K-box  14 aeslqqelakLkkeienLqreqRhllGedLesLslkeLqqLeqqLekslkkiRskKnellleqieelqkkekelqeenkaLrkklee 100
                    +   ++e++ Lk+eie Lq+ +R +   + ++++l eLq Le++Le  + ++Rs K+++l+++i+ l++ e  l  +nk+L+ k+ee
  MDP0000316609 126 MHDAKKEINLLKQEIEILQKGLRYMFDGGAGTMTLDELQVLEKNLEIWIYHVRSAKMDILFQEIQLLRNSEGVLTAANKYLQDKIEE 212
                    566799******************************************************************************997 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF554551.15E-24161IPR002100Transcription factor, MADS-box
PROSITE profilePS5006629.198161IPR002100Transcription factor, MADS-box
SMARTSM004322.8E-35160IPR002100Transcription factor, MADS-box
CDDcd002651.49E-36285No hitNo description
PRINTSPR004042.0E-26323IPR002100Transcription factor, MADS-box
PfamPF003191.1E-211056IPR002100Transcription factor, MADS-box
PRINTSPR004042.0E-262338IPR002100Transcription factor, MADS-box
PRINTSPR004042.0E-263859IPR002100Transcription factor, MADS-box
PROSITE profilePS5129710.714126216IPR002487Transcription factor, K-box
PfamPF014861.8E-18128210IPR002487Transcription factor, K-box
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0010228Biological Processvegetative to reproductive phase transition of meristem
GO:0048364Biological Processroot development
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 239 aa     Download sequence    Send to blast
MARGKVQMKR IENPVHRQVT FCKRRVGLLK KAKELSVLCD AEIGVFIFSS HGKLFELATK  60
GSLALSIYFC IIIISMQGLI ERYMKMKPTR VSQVEQTVET QTLVRSSIXX YPYKAIHSDW  120
RVFSDMHDAK KEINLLKQEI EILQKGLRYM FDGGAGTMTL DELQVLEKNL EIWIYHVRSA  180
KMDILFQEIQ LLRNSEGVLT AANKYLQDKI EENTGVTNFI PMATDNTYPF TIPDDIFEC
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5f28_A2e-15159159MEF2C
5f28_B2e-15159159MEF2C
5f28_C2e-15159159MEF2C
5f28_D2e-15159159MEF2C
6byy_A2e-15159159MEF2 CHIMERA
6byy_B2e-15159159MEF2 CHIMERA
6byy_C2e-15159159MEF2 CHIMERA
6byy_D2e-15159159MEF2 CHIMERA
6bz1_A2e-15159159MEF2 CHIMERA
6bz1_B2e-15159159MEF2 CHIMERA
6bz1_C2e-15159159MEF2 CHIMERA
6bz1_D2e-15159159MEF2 CHIMERA
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: During embryo development, expressed in a punctate pattern from the globular stage to the torpedo stage. {ECO:0000269|PubMed:11855641}.
UniprotTISSUE SPECIFICITY: Preferentially expressed in roots (PubMed:7549482). In root meristem, expressed in external cells of columella, lateral root cap and atrichoblasts. In mature root, expressed in the central cylinder (PubMed:11855641). Expressed in leaf vasculature, young floral meristems and nectaries (PubMed:18203871). {ECO:0000269|PubMed:11855641, ECO:0000269|PubMed:18203871, ECO:0000269|PubMed:7549482}.
Functional Description ? help Back to Top
Source Description
UniProtProbable transcription activator that regulates root development by controlling cell proliferation in root meristem. May mediate responses to auxin in the root. May act as promoter of the flowering transition through up-regulation of SOC, FT and LFY. {ECO:0000269|PubMed:18203871}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By auxin in root phloem. {ECO:0000269|PubMed:18203871}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankKP1640241e-178KP164024.1 Pyrus pyrifolia clone PpAGL12-1 AGL12-like MADS-box protein mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_008383584.11e-140agamous-like MADS-box protein AGL12
SwissprotQ388417e-74AGL12_ARATH; Agamous-like MADS-box protein AGL12
TrEMBLA0A498HUU71e-139A0A498HUU7_MALDO; Uncharacterized protein
STRINGXP_008383584.11e-139(Malus domestica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF75663144
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G71692.13e-76AGAMOUS-like 12
Publications ? help Back to Top
  1. Zimmermann P,Hirsch-Hoffmann M,Hennig L,Gruissem W
    GENEVESTIGATOR. Arabidopsis microarray database and analysis toolbox.
    Plant Physiol., 2004. 136(1): p. 2621-32
    [PMID:15375207]
  2. Pacheco-Escobedo MA, et al.
    Longitudinal zonation pattern in Arabidopsis root tip defined by a multiple structural change algorithm.
    Ann. Bot., 2018.
    [PMID:27358290]
  3. García-Cruz KV, et al.
    The MADS-box XAANTAL1 increases proliferation at the Arabidopsis root stem-cell niche and participates in transition to differentiation by regulating cell-cycle components.
    Ann. Bot., 2018.
    [PMID:27474508]