PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000294096
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family TALE
Protein Properties Length: 357aa    MW: 40746.6 Da    PI: 6.195
Description TALE family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000294096genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox28.33e-093003342155
                    HSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHH CS
       Homeobox  21 knrypsaeereeLAkklgLterqVkvWFqNrRake 55 
                    k +yp+++++  LA+++gL++rq+ +WF N+R ++
  MDP0000294096 300 KWPYPTEADKIALAESTGLDQRQINNWFINQRKRH 334
                    569*****************************885 PP
2ELK26.61.4e-09254275122
            ELK   1 ELKhqLlrKYsgyLgsLkqEFs 22 
                    +LK++L+r ++++Lg+Lk EFs
  MDP0000294096 254 DLKDRLMRRFGSHLGTLKLEFS 275
                    69*******************8 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM012551.6E-1985129IPR005540KNOX1
PfamPF037902.8E-1886128IPR005540KNOX1
SMARTSM012562.1E-25145196IPR005541KNOX2
PfamPF037911.9E-24149195IPR005541KNOX2
PROSITE profilePS512139.586254274IPR005539ELK domain
PfamPF037896.8E-7254275IPR005539ELK domain
SMARTSM011881.3E-4254275IPR005539ELK domain
PROSITE profilePS5007112.876274337IPR001356Homeobox domain
SuperFamilySSF466898.55E-20275350IPR009057Homeodomain-like
SMARTSM003891.4E-13276341IPR001356Homeobox domain
Gene3DG3DSA:1.10.10.605.4E-28279338IPR009057Homeodomain-like
CDDcd000865.09E-12286338No hitNo description
PfamPF059203.6E-17294333IPR008422Homeobox KN domain
PROSITE patternPS000270312335IPR017970Homeobox, conserved site
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0010073Biological Processmeristem maintenance
GO:0005634Cellular Componentnucleus
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 357 aa     Download sequence    Send to blast
MADYGDTGFQ STAEYENRAA LMTPENLILP LDYRSLLVSS GAFREHNHHH HQREAMFGSN  60
DSVLYSAASE AASTTIVQRE VDVFGAIKAR IASHPTYPRL IHAYIECQKV GASPEIAGFL  120
DEIRRKNDLY KKQGDYSCNS SSMFSSTCLG ADPELDEFME TYCDMLVKYK SDLSRTFDEA  180
TTFLSKIETQ LTNLCTSSSS ARVSSSRNLE KDTRWILFLR ILGSYEGGGM SSDEDFSGGE  240
IDVQEAQQRG EDRDLKDRLM RRFGSHLGTL KLEFSKKKKK GKLPKEARQT LLDWWSVHYK  300
WPYPTEADKI ALAESTGLDQ RQINNWFINQ RKRHWRPSEN MQLAMMNDLT GPFFTDE
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: First detected in torpedo stage embryos at the boundaries between the presumptive SAM and the cotyledons. Later expressed between the cotyledons and the meristem, and between the cotyledons. In seedlings, localised in stipules and at the boundaries between the SAM and the emerging primordia. Expressed at the site of lateral roots. {ECO:0000269|PubMed:16798887}.
UniprotTISSUE SPECIFICITY: Expressed predominantly in shoot apices of seedlings, and, to a lower extent, in rosette leaves. {ECO:0000269|PubMed:11311158}.
Functional Description ? help Back to Top
Source Description
UniProtPlays a role in meristem function. Contributes to the shoot apical meristem (SAM) maintenance and organ separation by controlling boundary establishment in embryo in a CUC1, CUC2 and STM-dependent manner. Involved in maintaining cells in an undifferentiated, meristematic state. Probably binds to the DNA sequence 5'-TGAC-3'. {ECO:0000269|PubMed:16798887}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Seems to be repressed by AS2 and AS1 but induced by STM, CUC1 and CUC2. {ECO:0000269|PubMed:11311158, ECO:0000269|PubMed:16798887}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_008340074.10.0homeobox protein knotted-1-like 6
SwissprotQ84JS61e-131KNAT6_ARATH; Homeobox protein knotted-1-like 6
TrEMBLA0A498HKW20.0A0A498HKW2_MALDO; 2-phytyl-1,4-beta-naphthoquinone methyltransferase, chloroplastic
STRINGXP_008340073.10.0(Malus domestica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF62034125
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G23380.11e-121KNOTTED1-like homeobox gene 6
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Khan M, et al.
    Repression of Lateral Organ Boundary Genes by PENNYWISE and POUND-FOOLISH Is Essential for Meristem Maintenance and Flowering in Arabidopsis.
    Plant Physiol., 2015. 169(3): p. 2166-86
    [PMID:26417006]