PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

MDP0000285150

Organism

Malus domestica

Taxonomic ID

3750

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus

Family

G2-like

Protein Properties

Length: 713aa MW: 79853.8 Da PI: 6.3453

Description

G2-like family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
MDP0000285150	genome	GDR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	G2-like	107.5	7.4e-34	486	540	1	55
G2-like 1 kprlrWtpeLHerFveaveqLGGsekAtPktilelmkvkgLtlehvkSHLQkYRl 55 k+r+rWtpeLHe+Fveav+qLGGse+AtPk +l+lmkv+gLt++hvkSHLQkYR+ MDP0000285150 486 KARMRWTPELHEAFVEAVNQLGGSERATPKGVLKLMKVEGLTIYHVKSHLQKYRT 540 68****************************************************8 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF56784	9.07E-7	64	191	IPR023214	HAD-like domain
Gene3D	G3DSA:3.40.50.1000	1.0E-5	64	191	IPR023214	HAD-like domain
Pfam	PF03767	6.5E-32	88	201	IPR005519	Acid phosphatase, class B-like
PROSITE profile	PS51294	13.077	483	543	IPR017930	Myb domain
SuperFamily	SSF46689	1.51E-17	484	540	IPR009057	Homeodomain-like
Gene3D	G3DSA:1.10.10.60	1.7E-31	485	542	IPR009057	Homeodomain-like
TIGRFAMs	TIGR01557	1.6E-24	486	540	IPR006447	Myb domain, plants
Pfam	PF00249	7.6E-10	488	539	IPR001005	SANT/Myb domain
Pfam	PF14379	4.7E-25	571	618	IPR025756	MYB-CC type transcription factor, LHEQLE-containing domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0007623	Biological Process	circadian rhythm
GO:0016036	Biological Process	cellular response to phosphate starvation
GO:0055063	Biological Process	sulfate ion homeostasis
GO:0071486	Biological Process	cellular response to high light intensity
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 713 aa Download sequence Send to blast
MAKLVGFLVF FTAFVVAAAD WNILKTRQTD NVELGDELKK YCESWRINVE VNNIRGFEVV 60 PQECVWYVKK YMTSSQYKAD SQKALEEAWM REGKAPALEH TLKLFHEIKD RGIKIFLISS 120 RREDLRSSSV DNLIRVGYHG WTGFILRGLE DEFKEVQKYK SDARRRLXDE GYRIWGIIGD 180 QWSSFEGLPM AKRTFKLPNS MRKLMTPFSG FAVNNKQKME ARPAMSIRTS AAKQLTHMGV 240 SAAMSSSLPV LPTSLEETYP KLPDSQQVSR ERELMTRPVG HAGXLTSNSG VVGHIFSSSS 300 GFSTDLHYSA LSPHEKQSKN SPFISQSSAA LPLPHSPHSG FLQSTESCPY PKENSGSWCT 360 DSLPGFLHFP VNSHVENSQI ESSSCSGIMX ADEFVKRHDW QDWADQLITD DDALTSNWNE 420 LLDDNSVTDL EQKMKYQAPQ PSSTFSAEQS QVHQQQPASS GEIIPAPSRE IISVPATSSA 480 NSAPAKARMR WTPELHEAFV EAVNQLGGSE RATPKGVLKL MKVEGLTIYH VKSHLQKYRT 540 ARYRPESSEG ASEKKLTSIE EMTSLDLKTG IEITEALRLQ MEVQKRLHEQ LEIQRNLQLR 600 IEEQGKYLQI MFEKQCKSGI DTLKRSSSNL DDPSAQPSDE MQVCPDKSEL DSSKLDQGET 660 ETDPVKANPT SSGGSQEPEG KQKSPEAEAL PENLEPDGGX SSPQPPKRAK IKE

Sequence ? help Back to Top

Protein Sequence Length: 713 aa Download sequence Send to blast

MAKLVGFLVF FTAFVVAAAD WNILKTRQTD NVELGDELKK YCESWRINVE VNNIRGFEVV  60
PQECVWYVKK YMTSSQYKAD SQKALEEAWM REGKAPALEH TLKLFHEIKD RGIKIFLISS  120
RREDLRSSSV DNLIRVGYHG WTGFILRGLE DEFKEVQKYK SDARRRLXDE GYRIWGIIGD  180
QWSSFEGLPM AKRTFKLPNS MRKLMTPFSG FAVNNKQKME ARPAMSIRTS AAKQLTHMGV  240
SAAMSSSLPV LPTSLEETYP KLPDSQQVSR ERELMTRPVG HAGXLTSNSG VVGHIFSSSS  300
GFSTDLHYSA LSPHEKQSKN SPFISQSSAA LPLPHSPHSG FLQSTESCPY PKENSGSWCT  360
DSLPGFLHFP VNSHVENSQI ESSSCSGIMX ADEFVKRHDW QDWADQLITD DDALTSNWNE  420
LLDDNSVTDL EQKMKYQAPQ PSSTFSAEQS QVHQQQPASS GEIIPAPSRE IISVPATSSA  480
NSAPAKARMR WTPELHEAFV EAVNQLGGSE RATPKGVLKL MKVEGLTIYH VKSHLQKYRT  540
ARYRPESSEG ASEKKLTSIE EMTSLDLKTG IEITEALRLQ MEVQKRLHEQ LEIQRNLQLR  600
IEEQGKYLQI MFEKQCKSGI DTLKRSSSNL DDPSAQPSDE MQVCPDKSEL DSSKLDQGET  660
ETDPVKANPT SSGGSQEPEG KQKSPEAEAL PENLEPDGGX SSPQPPKRAK IKE

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
6j4k_A	7e-32	485	544	1	60	Protein PHOSPHATE STARVATION RESPONSE 1
6j4k_B	7e-32	485	544	1	60	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_A	7e-32	485	544	1	60	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_C	7e-32	485	544	1	60	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_D	7e-32	485	544	1	60	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_F	7e-32	485	544	1	60	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_H	7e-32	485	544	1	60	Protein PHOSPHATE STARVATION RESPONSE 1
6j5b_J	7e-32	485	544	1	60	Protein PHOSPHATE STARVATION RESPONSE 1
Search in ModeBase

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	620	625	DTLKRS

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
Mdo.6265	1e-146	stem

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor involved in phosphate starvation signaling (PubMed:11511543, PubMed:17927693, PubMed:26586833). Binds as a dimer to P1BS, an imperfect palindromic sequence 5'-GNATATNC-3', to promote the expression of inorganic phosphate (Pi) starvation-responsive genes (PubMed:11511543, PubMed:20838596, PubMed:26586833). SPX1 is a competitive inhibitor of this DNA-binding (PubMed:25271326). PHR1 binding to its targets is low Pi-dependent (PubMed:25271326). Regulates the expression of miR399 (PubMed:20838596). Regulates the expression of IPS1 (At3g09922), a non-coding RNA that mimics the target of miR399 to block the cleavage of PHO2 under Pi-deficient conditions (PubMed:17643101). Regulates lipid remodeling and triacylglycerol accumulation during phosphorus starvation (PubMed:25680792). Required for the shoot-specific hypoxic response (PubMed:24753539). Regulates FER1 expression upon phosphate starvation, linking iron and phosphate homeostasis (PubMed:23788639). Contributes to the homeostasis of both sulfate and phosphate in plants under phosphate deficiency (PubMed:21261953). Required for adaptation to high light and retaining functional photosynthesis during phosphate starvation (PubMed:21910737). Involved in the coregulation of Zn and Pi homeostasis (PubMed:24420568). {ECO:0000269\|PubMed:11511543, ECO:0000269\|PubMed:17643101, ECO:0000269\|PubMed:17927693, ECO:0000269\|PubMed:20838596, ECO:0000269\|PubMed:21261953, ECO:0000269\|PubMed:21910737, ECO:0000269\|PubMed:23788639, ECO:0000269\|PubMed:24420568, ECO:0000269\|PubMed:24753539, ECO:0000269\|PubMed:25271326, ECO:0000269\|PubMed:25680792, ECO:0000269\|PubMed:26586833}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Only moderately up-regulated by Pi starvation. {ECO:0000269\|PubMed:11511543}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_028954802.1	0.0	protein PHOSPHATE STARVATION RESPONSE 1-like isoform X1
Refseq	XP_028954803.1	0.0	protein PHOSPHATE STARVATION RESPONSE 1-like isoform X1
Refseq	XP_028954804.1	0.0	protein PHOSPHATE STARVATION RESPONSE 1-like isoform X1
Refseq	XP_028954805.1	0.0	protein PHOSPHATE STARVATION RESPONSE 1-like isoform X1
Refseq	XP_028954806.1	0.0	protein PHOSPHATE STARVATION RESPONSE 1-like isoform X1
Refseq	XP_028954807.1	0.0	protein PHOSPHATE STARVATION RESPONSE 1-like isoform X1
Swissprot	Q94CL7	1e-109	PHR1_ARATH; Protein PHOSPHATE STARVATION RESPONSE 1
TrEMBL	A0A498IV60	0.0	A0A498IV60_MALDO; Uncharacterized protein
STRING	XP_009370360.1	0.0	(Pyrus x bretschneideri)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF1512	34	98

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT4G28610.1	1e-112	phosphate starvation response 1

Link Out ? help Back to Top
Phytozome	MDP0000285150

Publications ? help Back to Top
Duarte JM, et al. Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis. Mol. Biol. Evol., 2006. 23(2): p. 469-78 [PMID:16280546] Matsui K,Togami J,Mason JG,Chandler SF,Tanaka Y Enhancement of phosphate absorption by garden plants by genetic engineering: a new tool for phytoremediation. Biomed Res Int, 2013. 2013: p. 182032 [PMID:23984322] Jost R, et al. Differentiating phosphate-dependent and phosphate-independent systemic phosphate-starvation response networks in Arabidopsis thaliana through the application of phosphite. J. Exp. Bot., 2015. 66(9): p. 2501-14 [PMID:25697796] Zhou Z, et al. SPX proteins regulate Pi homeostasis and signaling in different subcellular level. Plant Signal Behav, 2015. 10(9): p. e1061163 [PMID:26224365] Bonnot C, et al. A chemical genetic strategy identify the PHOSTIN, a synthetic molecule that triggers phosphate starvation responses in Arabidopsis thaliana. New Phytol., 2016. 209(1): p. 161-76 [PMID:26243630] Khan GA,Vogiatzaki E,Glauser G,Poirier Y Phosphate Deficiency Induces the Jasmonate Pathway and Enhances Resistance to Insect Herbivory. Plant Physiol., 2016. 171(1): p. 632-44 [PMID:27016448] Velasco VM, et al. Acclimation of the crucifer Eutrema salsugineum to phosphate limitation is associated with constitutively high expression of phosphate-starvation genes. Plant Cell Environ., 2016. 39(8): p. 1818-34 [PMID:27038434] Yong-Villalobos L, et al. Phosphate starvation induces DNA methylation in the vicinity of cis-acting elements known to regulate the expression of phosphate-responsive genes. Plant Signal Behav, 2016. 11(5): p. e1173300 [PMID:27185363] Li Y,Wu H,Fan H,Zhao T,Ling HQ Characterization of the AtSPX3 Promoter Elucidates its Complex Regulation in Response to Phosphorus Deficiency. Plant Cell Physiol., 2016. 57(8): p. 1767-78 [PMID:27382128] Zhang H,Huang L,Hong Y,Song F BOTRYTIS-INDUCED KINASE1, a plasma membrane-localized receptor-like protein kinase, is a negative regulator of phosphate homeostasis in Arabidopsis thaliana. BMC Plant Biol., 2016. 16(1): p. 152 [PMID:27389008] Yuan J, et al. Systematic characterization of novel lncRNAs responding to phosphate starvation in Arabidopsis thaliana. BMC Genomics, 2016. 17: p. 655 [PMID:27538394] Linn J, et al. Root Cell-Specific Regulators of Phosphate-Dependent Growth. Plant Physiol., 2017. 174(3): p. 1969-1989 [PMID:28465462] Aleksza D,Horváth GV,Sándor G,Szabados L Proline Accumulation Is Regulated by Transcription Factors Associated with Phosphate Starvation. Plant Physiol., 2017. 175(1): p. 555-567 [PMID:28765275] Liu Y, et al. Light and Ethylene Coordinately Regulate the Phosphate Starvation Response through Transcriptional Regulation of PHOSPHATE STARVATION RESPONSE1. Plant Cell, 2017. 29(9): p. 2269-2284 [PMID:28842534] Qi W,Manfield IW,Muench SP,Baker A AtSPX1 affects the AtPHR1-DNA-binding equilibrium by binding monomeric AtPHR1 in solution. Biochem. J., 2017. 474(21): p. 3675-3687 [PMID:28887383] Huang KL, et al. The ARF7 and ARF19 Transcription Factors Positively Regulate PHOSPHATE STARVATION RESPONSE1 in Arabidopsis Roots. Plant Physiol., 2018. 178(1): p. 413-427 [PMID:30026290] Jiang M, et al. Structural basis for the Target DNA recognition and binding by the MYB domain of phosphate starvation response 1. FEBS J., 2019. [PMID:30974511]