PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

MDP0000258338

Organism

Malus domestica

Taxonomic ID

3750

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus

Family

E2F/DP

Protein Properties

Length: 202aa MW: 22691.5 Da PI: 10.4455

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
MDP0000258338	genome	GDR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	61.7	1.1e-19	8	77	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliek.....kekneirwkg 71 r+eksL lltq+f+kl+ +s++ + + +++L d+ k+RRiYDi+NVL+++nliek ++k++++w g MDP0000258338 8 RREKSLALLTQNFVKLFVCSTKLLT---NFCSKL---DEAAKVRRIYDIANVLSSMNLIEKthtsdTRKPAFKWLG 77 689**************877655...568999...7778*******************999*****87 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	4.9E-21	4	78	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	4.8E-21	8	77	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	2.8E-16	10	77	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	2.45E-10	10	78	IPR011991	Winged helix-turn-helix DNA-binding domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 202 aa Download sequence Send to blast
MNPKSDNRRE KSLALLTQNF VKLFVCSTKL LTNFCSKLDE AAKVRRIYDI ANVLSSMNLI 60 EKTHTSDTRK PAFKWLGLRG KEEVPQETKK RAFGTDITNV SSKRGKVDSF IGGKLDGQKQ 120 KGLVGEADRS NLEDSKDGSK SYQFGPFAPV TIARAGTGNT RNVHDWEKLT STYRPQYQNQ 180 GPGDNSGRTR REVDRERNMT GD

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
Mdo.11534	1e-133	cell culture\| fruit

Expression -- Description ? help Back to Top
Source	Description
Uniprot	DEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Not detected during early S phase. Expressed at both the G1/S and S/G2 transitions, with a peak during G2. {ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:18787127}.
Uniprot	TISSUE SPECIFICITY: Expressed exclusively in mitotically dividing cells. Highly expressed in young leaves and mature flowers. Lower expression in young stalk and in young and mature flowers. {ECO:0000269\|PubMed:11867638, ECO:0000269\|PubMed:15649366}.

Functional Description ? help Back to Top
Source	Description
UniProt	Inhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11867638, ECO:0000269\|PubMed:15649366, ECO:0000269\|PubMed:18787127}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_008393070.2	1e-132	E2F transcription factor-like E2FE isoform X3
Swissprot	Q8LSZ4	8e-45	E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBL	A0A498I5U6	1e-115	A0A498I5U6_MALDO; Uncharacterized protein
STRING	XP_008393069.1	1e-128	(Malus domestica)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF3668	33	66

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G48160.1	7e-48	DP-E2F-like 1

Link Out ? help Back to Top
Phytozome	MDP0000258338

Publications ? help Back to Top
Chandran D, et al. Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid. Cell Host Microbe, 2014. 15(4): p. 506-13 [PMID:24721578] Wang Z, et al. Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis. PLoS ONE, 2016. 11(8): p. e0160684 [PMID:27505251] Heyman J,Polyn S,Eekhout T,De Veylder L Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1. Plant Physiol., 2017. 175(1): p. 303-313 [PMID:28698355]