PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000254847
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family TALE
Protein Properties Length: 461aa    MW: 51928.6 Da    PI: 6.4466
Description TALE family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000254847genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox23.78.4e-084074412155
                    HSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHH CS
       Homeobox  21 knrypsaeereeLAkklgLterqVkvWFqNrRake 55 
                    k +yp+++++  LA+ ++L+++q+ +WF N+R ++
  MDP0000254847 407 KWPYPTEADKISLAQVTRLDQKQINNWFINQRKRH 441
                    569*****************************885 PP
2ELK30.67.4e-11361381121
            ELK   1 ELKhqLlrKYsgyLgsLkqEF 21 
                    ELK+ Llr Ysgy+++Lk EF
  MDP0000254847 361 ELKDKLLRRYSGYISTLKREF 381
                    9*******************9 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM012553.5E-19113157IPR005540KNOX1
PfamPF037901.6E-18118155IPR005540KNOX1
SMARTSM012561.6E-20166217IPR005541KNOX2
PfamPF037915.1E-21171215IPR005541KNOX2
PROSITE profilePS5121310.65361381IPR005539ELK domain
PfamPF037894.3E-9361381IPR005539ELK domain
SMARTSM011881.7E-6361382IPR005539ELK domain
PROSITE profilePS5007111.548381444IPR001356Homeobox domain
SMARTSM003893.0E-10383448IPR001356Homeobox domain
SuperFamilySSF466892.91E-18383455IPR009057Homeodomain-like
CDDcd000861.66E-13384445No hitNo description
Gene3DG3DSA:1.10.10.604.9E-26386446IPR009057Homeodomain-like
PfamPF059206.2E-16401440IPR008422Homeobox KN domain
PROSITE patternPS000270419442IPR017970Homeobox, conserved site
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 461 aa     Download sequence    Send to blast
MMEDLYGLAG SSSTPSAGFS SDLYYSSSMA AMPFSANQTV PDHQLDYYCN YRSRSASFEP  60
LAAALGEQRI PGTMRPDQMF SGSSSGVSDA ASVVAAGIQR GGGERGWGEE VSCQMNEMIA  120
SHPLYPKLLQ AYIDCQKVGA PPEIASVLDE IRPQSDHLIS RRPTDSTCMA TADPDLDLFM  180
ESYCDILFKY KSDLTRPFDE AITFLNKMET QLNALANNTK LLKLYTKYVL GVLYLQIVRF  240
LAGTSLKFES LKSYLVLALY VVTLFIHRGV HCCAASLGSN WGVSESGNQL MCMAGPLFHQ  300
LVPQFCSMPI WDHGDPSLHA HMVETQSLKS KHDAAGSSDE EDWSGGEIEA QDSPRTNENH  360
ELKDKLLRRY SGYISTLKRE FTKKKKNGKL PREARQILFD WWNLHYKWPY PTEADKISLA  420
QVTRLDQKQI NNWFINQRKR HWKPSENMQY AVMDSLYGXQ D
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: First detected in torpedo stage embryos at the boundaries between the presumptive SAM and the cotyledons. Later expressed between the cotyledons and the meristem, and between the cotyledons. In seedlings, localised in stipules and at the boundaries between the SAM and the emerging primordia. Expressed at the site of lateral roots. {ECO:0000269|PubMed:16798887}.
UniprotTISSUE SPECIFICITY: Expressed predominantly in shoot apices of seedlings, and, to a lower extent, in rosette leaves. {ECO:0000269|PubMed:11311158}.
Functional Description ? help Back to Top
Source Description
UniProtPlays a role in meristem function. Contributes to the shoot apical meristem (SAM) maintenance and organ separation by controlling boundary establishment in embryo in a CUC1, CUC2 and STM-dependent manner. Involved in maintaining cells in an undifferentiated, meristematic state. Probably binds to the DNA sequence 5'-TGAC-3'. {ECO:0000269|PubMed:16798887}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Seems to be repressed by AS2 and AS1 but induced by STM, CUC1 and CUC2. {ECO:0000269|PubMed:11311158, ECO:0000269|PubMed:16798887}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_008393011.21e-146homeobox protein knotted-1-like 6
SwissprotQ84JS63e-47KNAT6_ARATH; Homeobox protein knotted-1-like 6
TrEMBLA0A498JKW11e-132A0A498JKW1_MALDO; Uncharacterized protein
STRINGXP_008393011.11e-145(Malus domestica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF62034125
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G23380.12e-49KNOTTED1-like homeobox gene 6
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Khan M, et al.
    Repression of Lateral Organ Boundary Genes by PENNYWISE and POUND-FOOLISH Is Essential for Meristem Maintenance and Flowering in Arabidopsis.
    Plant Physiol., 2015. 169(3): p. 2166-86
    [PMID:26417006]