PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000221977
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family NAC
Protein Properties Length: 409aa    MW: 47649.4 Da    PI: 8.2632
Description NAC family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000221977genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1NAM175.31.7e-54281581129
            NAM   1 lppGfrFhPtdeelvveyLkkkvegkkleleevikevdiykvePwdLpk..kvka.eekewyfFskrdkkyatgkrknratksgyWkatgkdkevl 93 
                    +ppGfrF+Ptdeelv++yL+kk+++k +++ +vi++vd+yk+ePwdL+   k+ + +++ewyfFs++dkky+tg+r+nratk+g+Wkatg+dk+++
  MDP0000221977  28 VPPGFRFRPTDEELVDYYLRKKIASKLIDF-DVIRDVDLYKIEPWDLEDlcKIGSgDQNEWYFFSHKDKKYPTGSRTNRATKAGFWKATGRDKAIY 122
                    69***************************9.9***************943466553556************************************* PP

            NAM  94 skkgelvglkktLvfykgrapkgektdWvmheyrle 129
                    + ++ lvg++ktLvfykgrap+g+k+dW+mheyrle
  MDP0000221977 123 RGEKFLVGMRKTLVFYKGRAPNGQKSDWIMHEYRLE 158
                    *99999****************************85 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF1019417.45E-5720195IPR003441NAC domain
PROSITE profilePS5100557.47828195IPR003441NAC domain
PfamPF023652.5E-2829157IPR003441NAC domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0048759Biological Processxylem vessel member cell differentiation
GO:1901348Biological Processpositive regulation of secondary cell wall biogenesis
GO:0003677Molecular FunctionDNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 409 aa     Download sequence    Send to blast
MAYSIVRINK VFHHYPQVKN MNTLSSHVPP GFRFRPTDEE LVDYYLRKKI ASKLIDFDVI  60
RDVDLYKIEP WDLEDLCKIG SGDQNEWYFF SHKDKKYPTG SRTNRATKAG FWKATGRDKA  120
IYRGEKFLVG MRKTLVFYKG RAPNGQKSDW IMHEYRLETR ENGTPQAKFK QDNQVLVCCR  180
SYHEEGWAVC RVFKKKLAAV SRMGDYVSPD CYDQVSFLPQ LDNPPRTSMS RTYASQNEQQ  240
LHYSQCKKEF DLQYNMPHHH HDSFLQLPQL ESPKVPHQSA TPYGNCAMQS STLTQEEQFA  300
QYISQQNMFK SSSSPSVHAL DNNNDYLEAV DQVKDWRALD KYVASQLSHD QQDASKKVTN  360
YSHAEEIFHV AEHINMLAND ASRRRDNNNN IGQDYASIST STFQIDLWK
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
3ulx_A5e-442719614169Stress-induced transcription factor NAC1
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Up-regulated during xylem vessel element formation. Expressed preferentially in procambial cells adjacent to root meristem. {ECO:0000269|PubMed:16103214, ECO:0000269|PubMed:25148240}.
UniprotTISSUE SPECIFICITY: Expressed in root, shoot and hypocotyl vascular elements, columella root caps, epidermal and cortex root cells and root-hypocotyl junctions. Observed predominantly in root imature xylem vessels (PubMed:18445131). Present in root developing xylems (PubMed:16103214, PubMed:17565617). Specifically expressed in vessels in the secondary xylem of the root-hypocotyl region, and in vessels but not in interfascicular fibers in stems (PubMed:25148240). {ECO:0000269|PubMed:16103214, ECO:0000269|PubMed:17565617, ECO:0000269|PubMed:18445131, ECO:0000269|PubMed:25148240}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds to the secondary wall NAC binding element (SNBE), 5'-(T/A)NN(C/T)(T/C/G)TNNNNNNNA(A/C)GN(A/C/T)(A/T)-3', in the promoter of target genes (By similarity). Involved in xylem formation by promoting the expression of secondary wall-associated transcription factors and of genes involved in secondary wall biosynthesis and programmed cell death, genes driven by the secondary wall NAC binding element (SNBE). Triggers thickening of secondary walls (PubMed:16103214, PubMed:25148240). {ECO:0000250|UniProtKB:Q9LVA1, ECO:0000269|PubMed:16103214, ECO:0000269|PubMed:25148240}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00136DAPTransfer from AT1G12260Download
Motif logo
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_028954148.10.0NAC domain-containing protein 7-like isoform X1
SwissprotQ9FWX21e-122NAC7_ARATH; NAC domain-containing protein 7
TrEMBLA0A498JZ270.0A0A498JZ27_MALDO; Uncharacterized protein
STRINGXP_008354411.10.0(Malus domestica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF126933106
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G12260.11e-123NAC 007
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]