PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

MDP0000214734

Organism

Malus domestica

Taxonomic ID

3750

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus

Family

GRF

Protein Properties

Length: 546aa MW: 60181.1 Da PI: 8.4265

Description

GRF family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
MDP0000214734	genome	GDR	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	WRC	75.9	4.1e-24	150	193	1	44
WRC 1 daepgrCrRtDGKkWRCsrrvlegkklCErHlhrgrsrsrkske 44 d+ep rCrRtDGKkWRCsr+v++g+k+CErH+hrgr+rsrk+ e MDP0000214734 150 DPEPTRCRRTDGKKWRCSRDVVAGQKYCERHVHRGRNRSRKPXE 193 79***************************************976 PP
2	QLQ	51.9	2.2e-18	78	114	1	37
QLQ 1 saFTaaQlqlLksQilAyKyLaanqPvPpeLlqaiqk 37 s+F+ +Q+q+L+ Q+l+++y+aa++ vP+eLlq+i+k MDP0000214734 78 SYFSLSQWQELELQALIFRYMAAGAAVPSELLQPIRK 114 78*********************************86 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SMART	SM00951	1.9E-9	78	114	IPR014978	Glutamine-Leucine-Glutamine, QLQ
Pfam	PF08880	8.3E-13	79	113	IPR014978	Glutamine-Leucine-Glutamine, QLQ
PROSITE profile	PS51666	21.061	79	114	IPR014978	Glutamine-Leucine-Glutamine, QLQ
PROSITE profile	PS51667	24.596	150	194	IPR014977	WRC domain
Pfam	PF08879	7.7E-21	151	192	IPR014977	WRC domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0005524	Molecular Function	ATP binding

Sequence ? help Back to Top
Protein Sequence Length: 546 aa Download sequence Send to blast
MDFYLKQWKP QQQEQSEEQH SAKIPKLDLD PHQNSEHPTA GSAAGYALPL FVSEPNTKIL 60 SAFSDSSPAT SRFPKMGSYF SLSQWQELEL QALIFRYMAA GAAVPSELLQ PIRKSLLXSA 120 PYFLHHPLQQ XPHFQPALLQ SGYWGRTAMD PEPTRCRRTD GKKWRCSRDV VAGQKYCERH 180 VHRGRNRSRK PXEVTTTTTT TTTACGGGSG SNLSIATTTT NTSASGAHFA LSGSSSSPSV 240 DLLHLNQSSS ESKPENRSLF ESRGEFSASA KSDSHVLRPF FDDWQGKLQE LDNSGSRPXS 300 MNSATSLSIS IRGNTSSDVS LKLSTGNGVE PGHQDSHAER GQPQLNWPAG WATNQMASMG 360 GPLAEALRSS SNSNSSPTSK CSCNLLVSVE SSDLENKVIF EXPIVDIQVS LCCILSPVGF 420 DEFDIELLIN YRKVIFKLRP SXQRQCSRTH ALNCELDLQF VKTLFARSHA LKSLIPFLGI 480 DKRMLGDXAL TCIGGSTYGP ETLQSPGETP VRIFGTLRLS GRLWWWLGVV ECRRFVQRFL 540 FGAVLA

Sequence ? help Back to Top

Protein Sequence Length: 546 aa Download sequence Send to blast

MDFYLKQWKP QQQEQSEEQH SAKIPKLDLD PHQNSEHPTA GSAAGYALPL FVSEPNTKIL  60
SAFSDSSPAT SRFPKMGSYF SLSQWQELEL QALIFRYMAA GAAVPSELLQ PIRKSLLXSA  120
PYFLHHPLQQ XPHFQPALLQ SGYWGRTAMD PEPTRCRRTD GKKWRCSRDV VAGQKYCERH  180
VHRGRNRSRK PXEVTTTTTT TTTACGGGSG SNLSIATTTT NTSASGAHFA LSGSSSSPSV  240
DLLHLNQSSS ESKPENRSLF ESRGEFSASA KSDSHVLRPF FDDWQGKLQE LDNSGSRPXS  300
MNSATSLSIS IRGNTSSDVS LKLSTGNGVE PGHQDSHAER GQPQLNWPAG WATNQMASMG  360
GPLAEALRSS SNSNSSPTSK CSCNLLVSVE SSDLENKVIF EXPIVDIQVS LCCILSPVGF  420
DEFDIELLIN YRKVIFKLRP SXQRQCSRTH ALNCELDLQF VKTLFARSHA LKSLIPFLGI  480
DKRMLGDXAL TCIGGSTYGP ETLQSPGETP VRIFGTLRLS GRLWWWLGVV ECRRFVQRFL  540
FGAVLA

Expression -- UniGene ? help Back to Top
UniGene ID	E-value	Expressed in
Mdo.11207	0.0	bud\| fruit\| leaf

Expression -- Description ? help Back to Top
Source	Description
Uniprot	DEVELOPMENTAL STAGE: Expressed during the early stages of leaf development and expression decreases with the maturation of the leaf. {ECO:0000269\|PubMed:20023165}.
Uniprot	TISSUE SPECIFICITY: Strongly expressed in actively growing and developing tissues, such as roots, upper stems, and shoot tips containing the shoot apical meristem (SAM) and flower buds. Also expressed in mature flowers, but weakly expressed in mature stems and leaves. {ECO:0000269\|PubMed:12974814}.

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that plays a role in the regulation of cell expansion in leaf and cotyledons tissues. Component of a network formed by miR396, the GRFs and their interacting factors (GIFs) acting in the regulation of meristem function, at least partially through the control of cell proliferation. {ECO:0000250}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: microRNA 396 (miR396a or miR396b) negatively regulates growth-regulating factors (GRF1-4 and GRF7-9). {ECO:0000269\|PubMed:15200956, ECO:0000269\|PubMed:19453503, ECO:0000269\|PubMed:20023165}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_008360545.2	0.0	growth-regulating factor 3-like
Swissprot	Q8L8A7	6e-86	GRF4_ARATH; Growth-regulating factor 4
TrEMBL	A0A498I561	0.0	A0A498I561_MALDO; Uncharacterized protein
STRING	XP_008360545.1	0.0	(Malus domestica)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF7895	32	42

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G52910.1	6e-66	growth-regulating factor 4

Link Out ? help Back to Top
Phytozome	MDP0000214734

Publications ? help Back to Top
Kuijt SJ, et al. Interaction between the GROWTH-REGULATING FACTOR and KNOTTED1-LIKE HOMEOBOX families of transcription factors. Plant Physiol., 2014. 164(4): p. 1952-66 [PMID:24532604] Cao Y,Han Y,Jin Q,Lin Y,Cai Y Comparative Genomic Analysis of the GRF Genes in Chinese Pear (Pyrus bretschneideri Rehd), Poplar (Populous), Grape (Vitis vinifera), Arabidopsis and Rice (Oryza sativa). Front Plant Sci, 2016. 7: p. 1750 [PMID:27933074]