PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Home  TFext  BLAST  Prediction  Download  Help  About  Links  PlantRegMap
(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000161241
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family C2H2
Protein Properties Length: 578aa    MW: 63522.4 Da    PI: 8.318
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000161241genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H2171.7e-056991123
                   EEETTTTEEESSHHHHHHHHHHT CS
        zf-C2H2  1 ykCpdCgksFsrksnLkrHirtH 23
                   ++C++C+k F r  nL+ H r H
  MDP0000161241 69 FVCEICNKGFQRDQNLQLHRRGH 91
                   89*******************88 PP
2zf-C2H215.45.4e-05145167123
                    EEETTTTEEESSHHHHHHHHHHT CS
        zf-C2H2   1 ykCpdCgksFsrksnLkrHirtH 23 
                    +kC +C+k +  +s+ k H++t+
  MDP0000161241 145 WKCDKCSKKYAVQSDWKAHQKTC 167
                    58*******************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF576676.97E-86891No hitNo description
Gene3DG3DSA:3.30.160.602.0E-56891IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003550.0176991IPR015880Zinc finger, C2H2-like
PROSITE profilePS5015710.9496991IPR007087Zinc finger, C2H2
PROSITE patternPS0002807191IPR007087Zinc finger, C2H2
SMARTSM0035598110140IPR015880Zinc finger, C2H2-like
Gene3DG3DSA:3.30.160.606.9E-5133166IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamilySSF576676.97E-8140166No hitNo description
SMARTSM0035594145165IPR015880Zinc finger, C2H2-like
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0003676Molecular Functionnucleic acid binding
GO:0046872Molecular Functionmetal ion binding
Sequence ? help Back to Top
Protein Sequence    Length: 578 aa     Download sequence    Send to blast
MSNITGDVEE GSFSSGNNTG ELEVRQDQKQ QENHLHRSSS GGASGAQSNN PSAEVIALSP  60
TTLMATNRFV CEICNKGFQR DQNLQLHRRG HNLPWKLRQR TTTEVRKRVY ICPEPTCVHH  120
NPARALGDLT GIKKHFSRKH GEKKWKCDKC SKKYAVQSDW KAHQKTCGTR EYKCDCGTIF  180
SRRDSFITHR AFCDALAEEN NKVNQMSMPH DQLISSTAMN TSTSTMGGGG VSEFLNYDIN  240
PNKNKLPEDL VPMPFKSMNM NMNIPGGGGG PGMFSSTAGS LFGGPRSVSS TSASSLQLSS  300
NNNNNSSSGF NYLHNQEIKN GGSSLSSITG AAQMSATALL QKAAQMGASA SNSTINSPMM  360
QKSFVSSMAG PDHGHLSSPN SLLNNNIRPP PSYDHQPHHF QQQPQASDPL SYNSHNMMGG  420
FTNQLMQKGP QEMSQLFDHH SNNSAASSAM TDMGLFSQVF MGIDGDPHQH HQSHQALLKN  480
FEQDHQNINS PTNNSSSSIS THRMNSALGP STTLDLLGIG GSRPPNLHEQ HHHHHNQQQR  540
LDLEAMSQHR LPAMMNPFQQ QQQRSHGDSA MEKQIWDV
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5b3h_C1e-34141207369Zinc finger protein JACKDAW
5b3h_F1e-34141207369Zinc finger protein JACKDAW
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Observed in vegetative tissues. Mainly expressed in hypocotyls, petioles, shoot apices, root tips, and trichomes, and, at low levels, in leaves, stems and flowers. {ECO:0000269|PubMed:25035403}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor that acts as a positive regulator of gibberellin (GA) action, homeostasis and signaling. GA converts the GAF1 complex from transcriptional activator to repressor via the degradation of DELLA proteins. {ECO:0000269|PubMed:25035403}.
UniProtTranscription factor that may act a transcriptional activator of nuclear-encoded photosynthetic gene expression (Probable). Binds DNA via its zinc fingers (PubMed:24821766). Recognizes and binds to SCL3 promoter sequence 5'-AGACAA-3' to promotes its expression when in complex with RGA (PubMed:24821766). {ECO:0000269|PubMed:24821766, ECO:0000305|PubMed:19726569}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Down-regulated by gibberellin. {ECO:0000305|PubMed:17933900}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_028945083.10.0zinc finger protein GAI-ASSOCIATED FACTOR 1-like
SwissprotQ8GYC11e-101IDD4_ARATH; Protein indeterminate-domain 4, chloroplastic
SwissprotQ9SCQ61e-101IDD2_ARATH; Zinc finger protein GAI-ASSOCIATED FACTOR 1
TrEMBLA0A498IM740.0A0A498IM74_MALDO; Uncharacterized protein
STRINGXP_008386763.10.0(Malus domestica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF21923085
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G44160.19e-89C2H2-like zinc finger protein
Publications ? help Back to Top
  1. Fukazawa J, et al.
    DELLAs function as coactivators of GAI-ASSOCIATED FACTOR1 in regulation of gibberellin homeostasis and signaling in Arabidopsis.
    Plant Cell, 2014. 26(7): p. 2920-38
    [PMID:25035403]
  2. Moreno-Risueno MA, et al.
    Transcriptional control of tissue formation throughout root development.
    Science, 2015. 350(6259): p. 426-30
    [PMID:26494755]
  3. Khare D, et al.
    Root avoidance of toxic metals requires the GeBP-LIKE 4 transcription factor in Arabidopsis thaliana.
    New Phytol., 2017. 213(3): p. 1257-1273
    [PMID:27768815]