PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000148939
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family LSD
Protein Properties Length: 307aa    MW: 33487.8 Da    PI: 9.0425
Description LSD family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000148939genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-LSD139.49.9e-13144168125
        zf-LSD1   1 CggCrtlLsYPrGApsVRCalCdtV 25 
                    C+gCr +L YPrGA++V+CalC+ +
  MDP0000148939 144 CSGCRSILLYPRGATNVCCALCNII 168
                    **********************976 PP
2zf-LSD142.97.7e-14183207125
        zf-LSD1   1 CggCrtlLsYPrGApsVRCalCdtV 25 
                    CggCrtlL+ +rGA+sVRCa+C+tV
  MDP0000148939 183 CGGCRTLLMHTRGATSVRCACCHTV 207
                    ************************9 PP
3zf-LSD148.51.4e-15221245125
        zf-LSD1   1 CggCrtlLsYPrGApsVRCalCdtV 25 
                    Cg+Crt+L+YP+GApsV+CalC+ V
  MDP0000148939 221 CGNCRTTLMYPYGAPSVKCALCQYV 245
                    **********************987 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF119555.7E-4010106IPR021099Plant organelle RNA recognition domain
TIGRFAMsTIGR010532.3E-11141169IPR005735Zinc finger, LSD1-type
PfamPF069431.2E-10144167IPR005735Zinc finger, LSD1-type
TIGRFAMsTIGR010531.1E-15180209IPR005735Zinc finger, LSD1-type
PfamPF069437.4E-12183207IPR005735Zinc finger, LSD1-type
TIGRFAMsTIGR010535.4E-13218248IPR005735Zinc finger, LSD1-type
PfamPF069434.6E-14221245IPR005735Zinc finger, LSD1-type
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0000303Biological Processresponse to superoxide
GO:0001666Biological Processresponse to hypoxia
GO:0002240Biological Processresponse to molecule of oomycetes origin
GO:0009626Biological Processplant-type hypersensitive response
GO:0009862Biological Processsystemic acquired resistance, salicylic acid mediated signaling pathway
GO:0010104Biological Processregulation of ethylene-activated signaling pathway
GO:0010310Biological Processregulation of hydrogen peroxide metabolic process
GO:0010602Biological Processregulation of 1-aminocyclopropane-1-carboxylate metabolic process
GO:0010618Biological Processaerenchyma formation
GO:0043069Biological Processnegative regulation of programmed cell death
Sequence ? help Back to Top
Protein Sequence    Length: 307 aa     Download sequence    Send to blast
MTEKKRLSKA GMMAVEKRAV AIVHVFLNLT VEKMVEVEKI SHFRKCFGFD VNIRDLFLDH  60
PGMFYLSTKG KRHTVFLREA YERGCLIHPN PVYNARRKLL DLVVLGXHGL FNDGSKPRNL  120
ASDKEAKSLE QHNEETSMQS QLVCSGCRSI LLYPRGATNV CCALCNIITP VPPPGTEMAQ  180
LICGGCRTLL MHTRGATSVR CACCHTVNLA PASSQVAHIN CGNCRTTLMY PYGAPSVKCA  240
LCQYVTNVGM SNMRVPIPAH RPNGTTNSGM VPSTSASQTV VVENPMSVDE SGKLVSNVVV  300
GVTTGKK
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Mdo.9130.0fruit
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in cotyledons, roots, rosette leaves, stems, inflorescences and flowers. {ECO:0000269|PubMed:20456049}.
Functional Description ? help Back to Top
Source Description
UniProtNegative regulator of reactive oxygen-induced cell death, cold stress-induced cell death, pathogen-induced hypersensitive response (HR), basal disease resistance. May be involved in the induction of the copper/zinc superoxide dismutase CSD1 and CSD2 that detoxify accumulating superoxide before the reactive oxygen species (ROS) can trigger a cell death cascade. LSD1 and LOL1 have antagonistic effects on CSD1 and CSD2 accumulation to regulate oxidative stress-induced cell death. Antagonizes the function of BZIP10, a positive regulator of cell death, by interacting in the cytoplasm and preventing its nuclear localization. Controls lysigenous aerenchyma in hypocotyls under root hypoxia. Required for leaf acclimation in response to excess excitation energy. {ECO:0000269|PubMed:10550898, ECO:0000269|PubMed:11595797, ECO:0000269|PubMed:11844114, ECO:0000269|PubMed:12732715, ECO:0000269|PubMed:15347794, ECO:0000269|PubMed:16957775, ECO:0000269|PubMed:18055613, ECO:0000269|PubMed:18790826, ECO:0000269|PubMed:20456049, ECO:0000269|PubMed:21097903}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By methyl viologen. {ECO:0000269|PubMed:20456049}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_008383355.11e-120protein LSD1-like isoform X2
SwissprotP940778e-73LSD1_ARATH; Protein LSD1
TrEMBLA0A498JZC30.0A0A498JZC3_MALDO; Uncharacterized protein
STRINGXP_004293683.11e-175(Fragaria vesca)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF40273361
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G20380.73e-75LSD family protein
Publications ? help Back to Top
  1. Spedaletti V, et al.
    Characterization of a lysine-specific histone demethylase from Arabidopsis thaliana.
    Biochemistry, 2008. 47(17): p. 4936-47
    [PMID:18393445]
  2. Szechyńska-Hebda M,Czarnocka W,Hebda M,Bernacki MJ,Karpiński S
    PAD4, LSD1 and EDS1 regulate drought tolerance, plant biomass production, and cell wall properties.
    Plant Cell Rep., 2016. 35(3): p. 527-39
    [PMID:26754794]
  3. Czarnocka W, et al.
    The dual role of LESION SIMULATING DISEASE 1 as a condition-dependent scaffold protein and transcription regulator.
    Plant Cell Environ., 2017. 40(11): p. 2644-2662
    [PMID:28555890]
  4. Bernacki MJ, et al.
    LSD1-, EDS1- and PAD4-dependent conditional correlation among salicylic acid, hydrogen peroxide, water use efficiency and seed yield in Arabidopsis thaliana.
    Physiol Plant, 2019. 165(2): p. 369-382
    [PMID:30461017]