PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID MDP0000128326
Organism
Malus domestica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Maleae; Malus
Family ERF
Protein Properties Length: 327aa    MW: 35459.1 Da    PI: 7.1381
Description ERF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
MDP0000128326genomeGDRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1AP2507.5e-164392255
            AP2  2 gykGVrwdkkrgrWvAeIrdpseng.krkrfslgkfgtaeeAakaaiaarkkleg 55
                   ++ GVr+++ +grWvAeI+       ++ r +lg+f taeeAa+ +++a+  l+g
  MDP0000128326 43 KFVGVRQRP-SGRWVAEIKG----TtQKIRMWLGTFETAEEAARSYDEAACLLRG 92
                   799******.7******766....1346**********************99987 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF008475.5E-124392IPR001471AP2/ERF domain
SMARTSM003809.1E-3443106IPR001471AP2/ERF domain
SuperFamilySSF541716.54E-1843100IPR016177DNA-binding domain
Gene3DG3DSA:3.30.730.101.4E-2643100IPR001471AP2/ERF domain
CDDcd000181.98E-304399No hitNo description
PROSITE profilePS5103219.08543100IPR001471AP2/ERF domain
PRINTSPR003674.0E-74455IPR001471AP2/ERF domain
PRINTSPR003674.0E-76682IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 327 aa     Download sequence    Send to blast
MEFQFQRPQQ VSFAAAGIPK SSSKVGKLKG RNNNSRSNNN ANKFVGVRQR PSGRWVAEIK  60
GTTQKIRMWL GTFETAEEAA RSYDEAACLL RGSNARTNFI THVSLDSPLA SRIRNLLNTK  120
KGGGGGGGGA TKQLALLQHQ SSSTSTTTST SSDHDHLPPP SKQLVRKSST STTCTSTSSG  180
SDTTSLSSEV FHDNSLLFDD VYKPDLRNCN EDFELSSSSN TSQSNLPSWG SYQTGVDCFS  240
FAQQAFEFPK HQAAAALSSA ESNTTTTSTI CTAGEADSGL MDFERLKVER QISASLYAMN  300
GMQEYMETVH DPNEALWDLP PLCSLFC
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in roots, root hairs and leaves (PubMed:17827349). Expressed in root epidermis and root hairs (PubMed:23077241). {ECO:0000269|PubMed:17827349, ECO:0000269|PubMed:23077241}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor involved in symbiotic nodule signaling in response to rhizobial Nod factors (NFs) (PubMed:17449807, PubMed:17827349). Binds to the GCC-box (NF-responsive box) of ENOD11 promoter. Acts as transcriptional activator of NF-responsive box-containing target gene promoters in root hairs (PubMed:17827349). Functions as a transcriptional regulator required for root infection by symbiotic rhizobia, infection thread (IT) formation and maintenance, and nodule development. Necessary for NF-induced gene expression and spontaneous nodulation activated by CCAMK. Functions downstream of CCAMK to activate nodulation gene expression (PubMed:17449807). Involved in early stages of root nodule development. Functions redundantly with ERN2. Is essential with ERN2 for the initiation of root hair infection, and nodule organogenesis and development. Required for accurate expression of the NF signaling genes ENOD11 and ENOD12 (PubMed:23077241, PubMed:27208242). {ECO:0000269|PubMed:17449807, ECO:0000269|PubMed:17827349, ECO:0000269|PubMed:23077241, ECO:0000269|PubMed:27208242}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced in roots from 1 to 21 day after inoculation with Sinorhizobium meliloti (PubMed:17449807). Induced by Nod factors in root hairs (PubMed:17827349). {ECO:0000269|PubMed:17449807, ECO:0000269|PubMed:17827349}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_008391774.10.0ethylene-responsive transcription factor ERN1-like
SwissprotA2Q5W18e-96ERN1_MEDTR; Ethylene-responsive transcription factor ERN1
TrEMBLA0A498I1J31e-174A0A498I1J3_MALDO; Uncharacterized protein
STRINGXP_008391774.10.0(Malus domestica)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF33413069
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G19790.14e-37related to AP2 11
Publications ? help Back to Top
  1. Cerri MR, et al.
    Medicago truncatula ERN transcription factors: regulatory interplay with NSP1/NSP2 GRAS factors and expression dynamics throughout rhizobial infection.
    Plant Physiol., 2012. 160(4): p. 2155-72
    [PMID:23077241]
  2. Tang H, et al.
    An improved genome release (version Mt4.0) for the model legume Medicago truncatula.
    BMC Genomics, 2014. 15: p. 312
    [PMID:24767513]
  3. Cerri MR, et al.
    The Symbiosis-Related ERN Transcription Factors Act in Concert to Coordinate Rhizobial Host Root Infection.
    Plant Physiol., 2016. 171(2): p. 1037-54
    [PMID:27208242]